Zespół zmęczenia, depresja oraz jakość życia u pacjentów ze stwardnieniem rozsianym
Słowa kluczowemultiple sclerosis, depression, fatigue syndrome, quality of life
Introduction. Multiple sclerosis is a chronic disease of central nervous system of autoimmunological origin, in which next to an increased physical disability, neuropsychological disorders exist, that lead to significant decrease in patients’ quality of life.
Aim. The aim of the study was the assessment of prevalence of fatigue syndrome and depression in patients with multiple sclerosis and their influence on functioning in physical, cognitive and psychosocial dimension as well as on the quality of life.
Materials and Methods. 62 patients (37 females and 25 males) with relapsing-remitting subtype of multiple sclerosis and 15 patients with sciatica (9 females and 6 males) as the reference group were included in the study. Prevalence of fatigue syndrome and depression, as well as patients’ quality of life were assessed with use of Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI) and a standardized instrument for use as a measure of health outcome EQ-5D.
Results. Fatigue of moderate intensity was noticed in 45.16% (n=28) of patients with relapsing-remitting subtype of MS, when depression was apparent in 51.61% of patients (n=32), including mild depressive disorders in 33.8% of patients (n=21), moderate in 11.29% of patients and severe in 6.45% (n=4). The obtained results did not reach statistical significance when compared to results obtained in the reference group. Statistically significant dependence between the intensity of depression and influence of fatigue on functioning in psychosocial dimension was mainly observed in the group of patients with multiple sclerosis.
Conclusions. Fatigue syndrome and depression occur in significant part of patients with relapsing-remitting subtype of multiple sclerosis, disturbing their functioning in psychosocial dimension and considerably decreasing their quality of life. Increase in fatigue in general dimension has a significantly positive correlation with exacerbation of depression in the group of patients with relapsing-remitting subtype of multiple sclerosis. (JNNN 2017;6(2):81–87)
Alajbegovic A., Loga N., Tiro N., Alajbegovic S., Todorovic L., Jasminika-Djelilovic. Depression in multiple sclerosis patients. Med Arh. 2011;65(2):115–118.
Béthoux F. Fatigue and multiple sclerosis. Ann Readapt Med Phys. 2006;49(6):265–271, 355–360.
Dworzańska E., Mitosek-Szewczyk K., Stelmasiak Z. [Fatigue in multiple sclerosis]. Neurol Neurochir Pol. 2009;43(1):71–76.
Kasatkin D.S., Spirin N.N. Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis. Neurosci Behav Physiol. 2007;37(3):215–219.
Bakshi R. Fatigue associated with multiple sclerosis: diagnosis, impact and management. Mult Scler. 2003;9(3):219–227.
Braley T.J., Chervin R.D. Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment. Sleep. 2010;33(8):1061–1067.
Berard J.A., Bowman M., Atkins H.L., Freedman M.S., Walker L.A. Cognitive fatigue in individuals with multiple sclerosis undergoing immunoablative therapy and hematopoietic stem cell transplantation. J Neurol Sci. 2014;336(1–2):132–137.
Ferreira M.L. Cognitive deficits in multiple sclerosis: a systematic review. Arq Neuropsiquiatr. 2010;68(4):632–641.
Arnett P.A., Higginson C.I., Voss W.D., Randolph J.J., Grandey A.A. Relationship between coping, cognitive dysfunction and depression in multiple sclerosis. Clin Neuropsychol. 2002;16(3):341–355.
Mitosek-Szewczyk K., Kułakowska A., Bartosik-Psujek H., Hożejowski R., Drozdowski W., Stelmasiak Z. Quality of life in Polish patients with multiple sclerosis. Adv Med Sci. 2014;59(1):34–38.
Wynia K., van Wijlen A.T., Middel B., Reijneveld S.A., Meilof J.F. Change in disability profile and quality of life in multiple sclerosis patients: a five-year longitudinal study using the Multiple Sclerosis Impact Profile (MSIP). Mult Scler. 2012;18(5):654–661.
Fisk J.D., Ritvo P.G., Ross L., Haase D.A., Marrie T.J., Schlech W.F. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18(Suppl. 1):S79–83.
Steer R.A., Cavalieri T.A., Leonard D.M., Beck A.T. Use of the Beck Depression Inventory for Primary Care to screen for major depression disorders. Gen Hosp Psychiatry. 1999;21(2):106–111.
Bol Y., Duits A.A., Hupperts R.M., Vlaeyen J.W., Verhey F.R. The psychology of fatigue in patients with multiple sclerosis: a review. J Psychosom Res. 2009;66(1):3–11.
Norheim K.B., Jonsson G., Omdal R. Biological mechanisms of chronic fatigue. Rheumatology (Oxford). 2011;50(6):1009–1018.
Späth-Schwalbe E., Hansen K., Schmidt F. et al. Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab. 1998;83(5):1573–1579.
Ziemssen T. Multiple sclerosis beyond EDSS: depression and fatigue. J Neurol Sci. 2009;277(Suppl. 1):S37–41.
Pittion-Vouyovitch S., Debouverie M., Guillemin F., Vandenberghe N., Anxionnat R., Vespignani H. Fatigue in multiple sclerosis is related to disability, depression and quality of life. J Neurol Sci. 2006;243(1–2):39–45.
Salehpoor G., Rezaei S., Hosseininezhad M. Quality of life in multiple sclerosis (MS) and role of fatigue, depression, anxiety, and stress: A bicenter study from north of Iran. Iran J Nurs Midwifery Res. 2014;19(6):593–599.
Van Schependom J., D’hooghe M.B., De Schepper M. et al. Relative contribution of cognitive and physical disability components to quality of life in MS. J Neurol Sci. 2014;336(1–2):116–121.
Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Bez utworów zależnych 4.0 Międzynarodowe.
Liczba wyświetleń i pobrań: 73
Liczba cytowań: 0