Polyphenols of elderberry fruit – dietary support of the therapy of common cold and flu
Keywords
Elderberry, black elder, Sambucus nigra, antiviral activity, inuenzaAbstract
Black elderberry Sambucus nigra fruits and owers are widely known as folk-medicine. Currently, fruit extracts are valuated as medicinal food for relieving symptoms of colds and u. Scientic studies focus on proving antiviral properties of the preparations and their safety. In vitro experiments showed that elderberry extract inhibited the replication of common inuenza A and B strains and prevented viral adhesion. Methylated and esteried avonoids, e.g. 3-cyanidin sambubioside, may contribute to the antiviral activity. Elderberry juice contains from 36.4 till 615.0 mg/100 mL polyphenols and from 4.12 till 189.14 mg/100 mL anthocyanins and can be a dietary support of the therapy. e juice or products with standardized extracts available in drugstores should be recommended.
References
Fitoterapia i leki roślinne, red. Lamer-Zarawska E., Kowal-Gierczak B, Niedworok J., PZWL, Warszawa, 2007.
Youdim K.A., Martin A., Joseph J.A., Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress, Free Radical Biology & Medicine, 2000, 29(1), s. 51–60.
Murkovic M., Abuja P.M., Bergmann A.R., Zirngast A., Adam U., Winklhofer-Roob B.M., Toplak H., Eects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study, European Journal of Clinical Nutrition, 2004, 58(2), s. 244–249.
Zakay-Rones Z., Varsano N., Zlotnik M., Manor O., Regev L., Schlesinger M., Mumcuoglu M., Inhibition of several strains of inuenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of inuenza B Panama, Journal of Alternative and Complementary Medicine, 1995, 1(4), s. 361–369.
Roschek B. Jr, Fink R.C., McMichael M.D., Li D., Alberte R.S., Elderberry avonoids bind to and prevent H1N1 infection in vitro, Phytochemistry, 2009, 70(10), s. 1255–1261.
Swaminathan K., Dyason J.C., Maggioni A., von Itzstein M., Downard K.M., Binding of a natural anthocyanin inhibitor to inuenza neuraminidase by mass spectrometry, Analytical and Bioanalytical Chemistry, 2013, 405(20), s. 6563–6572.
Shahsavandi S., Ebrahimi M.M., Hasaninejad F., Interfering with lipid ra association: A mechanism to control inuenza virus infection by Sambucus Nigra, Iranian Journal of Pharmaceutical Research, 2017, 16(3), s. 1147–1154.
Tejero J., Jiménez P., Quinto E.J., Cordoba-Diaz D., Garrosa M., Cordoba-Diaz M., Gayoso M.J., Girbés T., Elderberries: a source of ribosome-inactivating proteins with lectin activity, Molecules, 2015, 20(2), s. 2364–2387.
Ho G.T., Zou Y.F., Aslaksen T.H., Wangensteen G., Barsett H., Structural characterization of bioactive pectic polysaccharides from elderowers (Sambuci aos), Carbohydrate Polymers, 2016, 135, s. 128–137.
Barsett H., Aslaksen T.H., Gildhyal P., Michaelsen T.E., Paulsen B.S., Comparison of carbohydrate structures and immunomodulating properties of extracts from berries and owers of Sambucus nigra L., European Journal of Medicinal Plants, 2012, 2(3),
s. 216–229.
Porter R.S., Bode R.F., A review of the antiviral properties of black elder (Sambucus nigra L.) products, Phytotherapy Research, 2017, 31, s. 533–554.
Milbury P.E., Cao G., Prior R.L., Blumberg J., Bioavailability of elderberry anthocyanins, Mechanisms of Ageing and Development, 2002, 123, s. 997–1006.
Assessment Report on Sambucus nigra L., os, Committee on Herbal Medicinal Products, European Medicines Agency Evaluation of Medicines for Human Use, 2008.
Assessment Report on Sambucus nigra L., fructus, Committee on Herbal Medicinal Products, European Medicines Agency Evaluation of Medicines for Human Use, EMA/HMPC/44208/2012.
Singleton L.V., Orthofer R., Lamuela-Raventos R.M., Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent, Methods in Enzymology, 1999, 14, s. 155–158.
Giusti M.M., Wrolstad R.E., Characterization and Measurement of Anthocyanins by UV-Visible Spectroscopy, Current Protocols in Food Analytical Chemistry, 2001, s. F1.2.1-F1.2.13.
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