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Journal of Education, Health and Sport

Health benefits of xylitol consumption - a literature review
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  • Health benefits of xylitol consumption - a literature review
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  3. Vol. 82 (2025) /
  4. Medical Sciences

Health benefits of xylitol consumption - a literature review

Authors

  • Martyna Brzoza Central Clinical Hospital of the Medical University of Lodz https://orcid.org/0009-0004-8975-4462
  • Julia Stawińska-Dudek Ortho.pl Dental and Orthodontic Centre, Buforowa 34, 52-131 Wroclaw, Poland https://orcid.org/0009-0008-1677-3741
  • Piotr Mikołajczyk NZOZ Novaaldent Alicja Olechowska-Rytel, Braci Gierymskich 5, 43-300 Bielsko-Biala https://orcid.org/0009-0003-0189-0164
  • Barbara Buras Amerident Non-public Health Care Institution civil law partnership Maria and Lazarz Legien, Jana Kasprowicza 7, 43-300 Bielsko-Biala, Poland https://orcid.org/0009-0008-9914-507X
  • Milena Orzeł Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland https://orcid.org/0009-0005-1303-2778
  • Bartłomiej Orzeł Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland https://orcid.org/0009-0003-1442-6790
  • Aleksandra Bielecka The Children’s Memorial Health Institute, Dzieci Polskich 20, 04-730 Warsaw, Poland https://orcid.org/0009-0009-3150-2058
  • Bartosz Dubniański Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroclaw, Poland https://orcid.org/0009-0002-8481-3297
  • Kornelia Stawińska Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland https://orcid.org/0009-0000-8128-5076

DOI:

https://doi.org/10.12775/JEHS.2025.82.60645

Keywords

caries, health care, oral health, sugar substitutes, xylitol, polyols

Abstract

Introduction and purpose:

Throughout the years xylitol has become a commonly used sugar substitute. Presenting similar level of sweetness to sucrose, it serves as a much healthier alternative. The aim of this article is to expand knowledge about the beneficial impact of xylitol on human health mainly focusing on aspects regarding oral health.

Materials and methods:

A thorough analysis of scientific databases such as PubMed and Google Scholar has been undertaken using the key words chosen based on their relevance to the matter in subject. Studies since the year 2017 have been analyzed in order to obtain the most up to date information.

The state of knowledge:

Xylitol, being the sweetest of all polyols, has been prevalently used as a sugar substitute due to its various favorable effects on both oral and general health. It may be incorporated into daily oral care regimen as a preventive measure counteracting caries development both in adults and in children. According to the investigated studies, it also acts as a prebiotic, presents low caloric value as well as low glycemic and insulinemic indices.

Conclusions:

Xylitol is characterized by its facile availability in various forms such as for example chewing gums, pastilles, toothpastes, wipes and mouth rinses. It is derived either from natural, mainly plant based sources, or it may also be extracted synthetically. Due to those reasons and its favorable properties, it may serve as a prevalent sugar substitute. Used in appropriate doses it is safe regardless of age and presents multiple advantageous effects on various aspects of human health.

References

1. Wölnerhanssen BK, Meyer-Gerspach AC. Effekte von Zuckerkonsum auf die Gesundheit und mögliche Alternativen. Therapeutische Umschau. 2019 Sep;76(3):111–6.

https://doi.org/10.1024/0040-5930/a001070

2. Gasmi Benahmed A, Gasmi A, Arshad M, Shanaida M, Lysiuk R, Peana M, et al. Health benefits of xylitol. Appl Microbiol Biotechnol. 2020 Sep 7;104(17):7225–37.

https://doi.org/10.1007/s00253-020-10708-7

3. Wölnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Islam MdS. Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review. Crit Rev Food Sci Nutr. 2020 Jul 3;60(12):1986–98.

https://doi.org/10.1080/10408398.2019.1623757

4. Ruiz-Ojeda FJ, Plaza-Díaz J, Sáez-Lara MJ, Gil A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Advances in Nutrition. 2019 Jan;10:S31–48.

https://doi.org/10.1093/advances/nmy037

5. Lenhart A, Chey WD. A Systematic Review of the Effects of Polyols on Gastrointestinal Health and Irritable Bowel Syndrome. Advances in Nutrition. 2017 Jul;8(4):587–96.

https://doi.org/10.3945/an.117.015560

6. Rice T, Zannini E, K. Arendt E, Coffey A. A review of polyols – biotechnological production, food applications, regulation, labeling and health effects. Crit Rev Food Sci Nutr. 2020 Jul 3;60(12):2034–51.

https://doi.org/10.1080/10408398.2019.1625859

7. ALHumaid J, Bamashmous M. Meta-analysis on the Effectiveness of Xylitol in Caries Prevention. J Int Soc Prev Community Dent. 2022 Mar;12(2):133–8. DOI: 10.4103/jispcd.JISPCD_164_21

8. Chen SY, Delacruz J, Kim Y, Kingston R, Purvis L, Sharma D. Effect of xylitol on Porphyromonas gingivalis : A systematic review. Clin Exp Dent Res. 2023 Apr 9;9(2):265–75.

https://doi.org/10.1002/cre2.724

9. Baranowski D, Rutkowska J, Antoniewska A. Ksylitol – rola technologiczna i żywieniowa. Zywnosc Nauka Technologia Jakosc/Food Science Technology Quality. 2020;123(2):5–21. DOI: 10.15193/zntj/2020/123/331

10. Wu YF, Salamanca E, Chen IW, Su JN, Chen YC, Wang SY, et al. Xylitol-Containing Chewing Gum Reduces Cariogenic and Periodontopathic Bacteria in Dental Plaque—Microbiome Investigation. Front Nutr. 2022 May 11;9.

https://doi.org/10.3389/fnut.2022.882636

11. Siqueira Fraga EG de, Teófilo Campos FM, Silva Cavalcante MP da, Barbosa Martins LF, Rodrigues Neto EM, Mimica MJ. Xylitol, a Promising Allied for Oral Heath. Journal of Young Pharmacists. 2020 Sep 22;12(3):197–200. DOI: 10.5530/jyp.2020.12.60

12. Oliveira GGC de, Freires DMT, Oliveira SG de, Guaraldi ALDM, Weyne SDC, Hirata Júnior R. Propriedades antibacterianas e anticariogênicas do xilitol: uma revisão da literatura. Rev Bras Odontol. 2018 Feb 21;75:1. http://dx.doi.org/10.18363/rbo.v75.2018.e960

13. El-Marakby Ahmed M, Al-Sabri FA, Labib LM. Anti-Carigenic Effect of Five-Carbon Sugar: Xylitol. Journal of Dental and Oral Health [Internet]. 2017 Jun 6 [cited 2025 Apr 17];3(6). Available from: https://scientonline.org/open-access/anti-cariogenic-effect-of-five-carbon-sugar-xylitol.pdf

14. Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC. Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review. Nutrients. 2019 Aug 6;11(8):1813. https://doi.org/10.3390/nu11081813

15. Takeuchi K, Asakawa M, Hashiba T, Takeshita T, Saeki Y, Yamashita Y. Effects of xylitol-containing chewing gum on the oral microbiota. J Oral Sci. 2018;60(4):588–94. https://doi.org/10.2334/josnusd.17-0446

16. Söderling E, Pienihäkkinen K. Effects of xylitol chewing gum and candies on the accumulation of dental plaque: a systematic review. Clin Oral Investig. 2022 Jan 22;26(1):119–29. https://doi.org/10.1007/s00784-021-04225-8

17. Zhan L. Rebalancing the Caries Microbiome Dysbiosis: Targeted Treatment and Sugar Alcohols. Adv Dent Res. 2018 Feb 22;29(1):110–6.

https://doi.org/10.1177/0022034517736498

18. Aluchna A. Ewolucja płukanek – przegląd piśmiennictwa. Nowa Stomatologia. 2022 Dec;27(4). DOI: 10.25121/NS.2022.27.4.152

19. Kujałowicz A. Słodkie dylematy. Charakterystyka wybranych cukrów i słodzików. Tutoring Gedanensis. 2022 Dec 19;7(3):25–40. https://doi.org/10.26881/tutg.2022.3.03

20. Ortiz-Sáez B, Aguilella-Traver M, Hernández-Pando C, Martínez-Salmerón EM, Muñoz-Barrio JE, Gómez-Moreno G. Is xylitol effective in the prevention of dental caries? A systematic review. J Clin Exp Dent. 2024;e1307–15. doi: 10.4317/jced.62008

21. Nijakowski K, Pelec M, Człapowska M, Kurhańska-Flisykowska A, Surdacka A. Wpływ nawyków higienicznych i dietetycznych na stan zdrowia jamy ustnej u młodzieży liceów patronackich Uniwersytetu Medycznego w Poznaniu – badanie ankietowe i kliniczne. Dental Forum. 2021 Aug 3;45(1):35–41. http://dx.doi.org/10.20883/df.2017.4

22. Ganter J, Hellwig E, Doerken S, Al-Ahmad A. In vitro evaluation of the cariogenic potential of rebaudioside A compared to sucrose and xylitol. Clin Oral Investig. 2020 Jan 27;24(1):113–22.

23. Aluckal E, Ankola A. Effectiveness of xylitol and polyol chewing gum on salivary streptococcus mutans in children: A randomized controlled trial. Indian Journal of Dental Research. 2018;29(4):445. DOI: 10.4103/ijdr.IJDR_307_16

24. Janakiram C, Deepan Kumar C, Joseph J. Xylitol in preventing dental caries: A systematic review and meta-analyses. J Nat Sci Biol Med. 2017;8(1):16.

doi: 10.4103/0976-9668.198344

25. Magacz M, Kędziora K, Drożdż R, Krzyściak W. Próchnica: historia, Mechanizmy Powstawania i Obrony oraz Niefluorkowe Metody Prewencji. Acta Uroboroi- w kręgu epidemii; monografia naukowa [Internet]. 2018 [cited 2025 Apr 17];27–48. Available from: https://ruj.uj.edu.pl/entities/publication/0b70dd55-f778-4c85-b632-2a9776b83a85

26. Kayalvizhi G, Nivedha D, Sajeev R, Suganya M, Ramesh V. Evaluating the Efficacy of Xylitol Wipes on Cariogenic Bacteria in 19- to 35-month-old Children: A Double-blind Randomized Controlled Trial. Int J Clin Pediatr Dent. 2018 Feb;11(1):13–7.

doi: 10.5005/jp-journals-10005-1476

27. Kirthiga M, Murugan M, Saikia A, Kirubakaran R. Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies. Pediatr Dent. 2019 Mar 15;41(2):95–112.

28. Xiao J, Alkhers N, Kopycka-Kedzierawski DT, Billings RJ, Wu TT, Castillo DA, et al. Prenatal Oral Health Care and Early Childhood Caries Prevention: A Systematic Review and Meta-Analysis. Caries Res. 2019;53(4):411–21. https://doi.org/10.1159/000495187

29. Nailis, Reca. THE EFFECT OF CONSUMING XYLITOL-CONTAINING CHEWING GUM ON PLAQUE INDEX IN FIFTH GRADE CHILDREN SDN 71 MIBO KOTA BANDA ACEH. DHeJA: Dental Health Journal of Aceh. 2022 Jul 28;1(1):76–86. DOI: 10.30867/dheja.v1i1.52

30. Teixeira Essenfelder L, Gomes AA, Miquelutti D, da Silva GF, Magalhães MLB. Effect of xylitol on salivary β ‐glucosidase in humans. Eur J Oral Sci. 2019 Oct 30;127(5):472–5.

DOI: 10.1111/eos.12649

31. Muñoz M da S, Pola NM, Colussi PRG, Rösing CK, Muniz FWMG. Association between salivary flow and dental caries in institutionalized adolescents: Cross-sectional study. J Oral Biol Craniofac Res. 2024 Jan;14(1):55–60. doi: 10.1016/j.jobcr.2023.12.004

32. Kurkiewicz J, Białoszewska K, Olczak-Kowalczyk D. Środki miejscowe łagodzące dolegliwości towarzyszące wyrzynaniu zębów mlecznych – przegląd produktów dostępnych na polskim rynku. Nowa Stomatologia. 2021 Mar;26(1).

https://doi.org/10.25121/NS.2021.26.1.3

33. Janket SJ, Benwait J, Isaac P, Ackerson LK, Meurman JH. Oral and Systemic Effects of Xylitol Consumption. Caries Res. 2019;53(5):491–501. DOI: 10.1159/000499194

Journal of Education, Health and Sport

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Published

2025-06-28

How to Cite

1.
BRZOZA, Martyna, STAWIŃSKA-DUDEK, Julia, MIKOŁAJCZYK, Piotr, BURAS, Barbara, ORZEŁ, Milena, ORZEŁ, Bartłomiej, BIELECKA, Aleksandra, DUBNIAŃSKI, Bartosz and STAWIŃSKA, Kornelia. Health benefits of xylitol consumption - a literature review. Journal of Education, Health and Sport. Online. 28 June 2025. Vol. 82, p. 60645. [Accessed 27 December 2025]. DOI 10.12775/JEHS.2025.82.60645.
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Vol. 82 (2025)

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Copyright (c) 2025 Martyna Brzoza, Julia Stawińska-Dudek, Piotr Mikołajczyk, Barbara Buras, Milena Orzeł, Bartłomiej Orzeł, Aleksandra Bielecka, Bartosz Dubniański, Kornelia Stawińska

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