State of hydrogen sulfide system in the rats brain under combined hyperhomocysteinemia and its correction

Abstract

Zaichko Natalia V., Yurchenko Peter A., Filchukov Denis A. State of hydrogen sulfide system in the rats brain under combined hyperhomocysteinemia and its correction. Journal of Education, Health and Sport. 2015;5(3):183-188. ISSN 2391-8306. DOI: 10.5281/zenodo.16349

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A183-188

https://pbn.nauka.gov.pl/works/549846

http://dx.doi.org/10.5281/zenodo.16349

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive

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Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

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© The Author (s) 2015;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.

STATE OF hydrogen SULFIDE SYSTEM IN the rats brain UNDER COMBINED hyperhomocysteinemia and its CORRECTION

Natalia V. Zaichko, Peter A. Yurchenko, Denis A. Filchukov

Department of biological and general chemistry,

National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Abstract

The state of hydrogen sulfide (H₂S) system was investigated in the brain of rat under combined hyperhomocysteinemia (HHC) and its correction by betaine, vitamins B₆, B₉, B₁₂ and trace element complex Esmin. Animals hold 14-days on starch-casein diet with 1% methionine in the absence of vitamins B₆, B₉, B₁₂ caused increase in homocysteine serum to 12.0 times. Combined HHC induced significant decrease in H₂S content and inhibition of H₂S-synthesizing enzymes in rat’s brain. Normalization of diet, administration of vitamins B₆, B₉, B₁₂ and Esmin for 7 days caused a decrease in serum homocysteine and increasing H₂S content in rat brain. Betaine administration also decreased HHC and but the effect on H₂S system in rat brain was not significant.

Keywords: homocysteine, hydrogen sulfide, enzymes, metabolism, brain, betaine, vitamins, trace element complex.