Effect of naringenin on antioxidative response and oxidative stress status in the lenses of diabetic rats
DOI:
https://doi.org/10.12775/HERB.2018.002Keywords
naringenin, lenses, rats, diabetes, oxidative stressAbstract
Naringenin is a naturally occurring flavonoid with an antioxidative activity. Among many, well-documented pharmacological properties, it reveals a beneficial effect on ocular structures in experimental animals. However, there is no report describing an effect of naringenin on oxidative stress parameters in the lenses of diabetic rats. Since hyperglycemia may induce oxidative stress and eventually cataract formation, the aim of this study was to evaluate the effect of naringenin administered orally at the doses of 50 and 100 mg/kg on selected oxidative stress parameters in the lenses of diabetic rats. The study was conducted on male rats, from which, after 4 weeks of naringenin administration, the lenses were isolated. In homogenates prepared from the lenses, total antioxidative response, total oxidative status, oxidative stress index as well as protein and non-protein thiol groups level were assessed. Obtained results indicate, that naringenin shows beneficial, antioxidative effect in the lenses of diabetic rats.
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