Wpływ naryngeniny na odpowiedź antyoksydacyjną oraz status oksydacyjny w soczewkach szczurów z cukrzycą
DOI :
https://doi.org/10.12775/HERB.2018.002Mots-clés
naryngenina, soczewki, szczury, cukrzyca, stres oksydacyjnyRésumé
Naryngenina to naturalnie występujący flawonoid o działaniu przeciwutleniającym. Wśród wielu udokumentowanych działań farmakologicznych, opisany jest również korzystny wpływ tego związku na struktury oka w różnych modelach eksperymentalnych. Brak jest jednak doniesień opisujących wpływ naryngeniny na parametry związane ze stresem oksydacyjnym w soczewkach szczurów w przebiegu cukrzycy. Ze względu na fakt, iż cukrzyca może indukować powstawanie stresu oksydacyjnego oraz w konsekwencji rozwój zaćmy, celem pracy była analiza wpływu naryngeniny podawanej doustnie w dawkach 50 i 100 mg/kg na wybrane parametry związane ze stresem oksydacyjnym w soczewkach szczurów z cukrzycą. Badanie wykonano na samcach szczurów, z których po 4 tygodniach podawania naryngeniny wyizolowano soczewki. W uzyskanych z soczewek homogenatach oznaczono całkowitą odpowiedź antyoksydacyjną, całkowity status oksydacyjny, współczynnik stresu oksydacyjnego oraz zawartość białkowych i niebiałkowych grup tiolowych. Uzyskane wyniki świadczą o korzystnym, przeciwutleniającym wpływie naryngeniny na soczewkę oka u szczurów z wywołaną cukrzycą.
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