Kwercetyna i resweratrol – najważniejsze polifenole w prewencjii terapii chorób cywilizacyjnych
DOI:
https://doi.org/10.12775/HERB.2026.006Parole chiave
resweratrol, kwercetyna, choroby cywilizacyjneAbstract
Badania nad właściwościami chemicznymi i biologicznymi dwóch najczęściej badanych polifenoli naturalnych, tj. kwercetyny i resweratrolu, są zaawansowane. Dokonano przeglądu literatury dotyczącej działania tych fitozwiązków na organizm człowieka. Stwierdzono, że posiadają one duży potencjał farmakologiczny w zapobieganiu i leczeniu wielu chorób cywilizacyjnych, w tym związanych z wiekiem. W badaniach in vitro i in vivo wykazują one m.in. właściwości przeciwutleniające, przeciwzapalne, antyproliferacyjne, przeciwnowotworowe, przeciwcukrzycowe i przeciwwirusowe, a więc pośrednio pełnią funkcję ochronną przed starzeniem się organizmu. Polifenole te nie są lekami, a jedynie składnikami suplementów diety. Obecnie prowadzi się, głównie w Stanach Zjednoczonych, randomizowane badania kliniczne nad skutecznością i bezpieczeństwem tych substancji jako
przyszłych leków.
Riferimenti bibliografici
[1] Singla R. K., Dubey, A. K., Garg, A., Sharma, R. K., Fiorino, M., Ameen, S. M., Haddad, M. A., Al-Hiary, M., Natural polyphenols, chemical classification, definition of classes, subcategories, and structures, Journal of AOAC International, 2019, 102(5), s. 1397–1400.
[2] Mense S. M., Hei T. K., Ganju R. K., Bhat H. K., Phytoestrogens and breast cancer prevention possible mechanisms of action, Environmental Health Perspectives Journal, 2008,116(4), s. 426–433.
[3] Pecyna P., Wargula J., Murias M., Kucinska M., More than resveratrol: New insights into stilbene-based compound, Biomolecule, 2020, 10(8), s. 1111.
[4] Sharma A., Shahzad B., Rehman A., Bhardwaj R., Landi M., Response of phenylpropanoid pathway and the role of polyphenols in plants under abiotic stress, Molecules, 2019, 24(13), s. 2452.
[5] Joseph M., The top 100 foods high in polyphenol, 2024, https:// michael joseph, msc, anutr. (stan na dzień 30 stycznia 2025).
[6] Wieloch A., Michocka K., Cieszyńska A., Polifenole w żywności, lekach oraz suplementach diety, Zeszyty Naukowe UE w Poznaniu, 2010, 244, s. 83–101.
[7] Sun W., Shahrajabian M. H., Therapeutic potential of phenolic compounds in medicinal plants-natural health products for human health, Molecule, 2023,28(4), s.1845.
[8] Leri M., Scuto M., Ontario M. L., Calabrese V., Healthy effects of plant polyphenols: molecular mechanism, International Journal of Molecular Sciences, 2020, 21(4), s.1250.
[9] Fila M., Chojnacki C., Chojnacki J., Blasiak J., Is an “epigenetic diet” for migraines justified? the case of folate and DNA methylation, Nutrients, 2019,11(11), s. 2763.
[10] Chun S., Kim M. J., Shin P. K., Park S. J., Yang H. J., Kim J. H., Lee K. H., Hong M., Kwon D. Y., Friso S., Lee H. J., Kim M. S., Choi S.W., Traditional Korean diet high in one-carbon nutrients increases global DNA methylation, implication for epigenetic diet, European Journal Nutrition, 2024, 63(7), s. 2511–2519.
[11] Karta charakterystyki, QUERCETIN, Sigma-Aldrich, Merck Life Science, sp. z o.o. Poznań 2023, s. 1–12.
[12] Saleh B., Machin L., Monzote L., Sharifi-Rad J., Ezzat S. M., Salem M. A., Merghany R. M., El Mahdy N. M., Kılıç C. S., Sytar O., Sharifi-Rad M., Sharopov F., Martins N., Martorell M., Cho W. C., Therapeutic potential of quercetin, new insights and perspectives for human health, ACS Omega, 2020, 20, s. 11849–11872.
[13] Mahmud A. R., Ema T. I., Siddiquee M. F., Shahriar A., Ahmed H., Mosfeq-Ul-Hasan M., Rahman N., Islam R., Uddin M. R., Mizan M. F. R., Natural flavonols, actions, mechanisms, and potential therapeutic utility for various disease, Beni-Suef University Journal of Basic and Applied Sciences, 2023, 12(1), s. 47.
[14] Calabrò A., Accardi G., Aiello A., Caruso C., Galimberti D., Candore G., Senotherapeutics to counteract senescent cells are prominent topics in the context of anti-ageing strategies, International Journal of Molecular Sciences, 2024, 25(3), s.179.
[15] Haytowitz D. B., Wu X., Bhagwat S., USDA database for the flavonoid content of selected foods, Release 3.3. US. Department of Agriculture, ARS, Nutrient Data Laboratory Home Page, Beltsville 2018.
[16] Nishimuro H., Ohnishi H., Sato M., Ohnishi-Kameyama M., Matsunaga I., Naito S., Ippoushi K., Oike H., Nagata T., Akasaka H., Saitoh S., Shimamoto K., Kobori M., Daily intake and seasonal food sources of quercetin in Japan, Nutrients, 2015, 7, s. 2345–2358.
[17] Dabeek W. M., Marra M. V., Dietary quercetin and kaempferol, bioavailability and potential cardiovascular-related bioactivity in humans, Nutrients, 2019,11(10), s. 2288.
[18] Notice Inventory-Agency Response, 2010, https://wayback.archive-it.org/7993/20171031012354 (stan na dzień 30 stycznia 2025).
[19] Kerna N. A., Ngwu D. C., Akuma O. M., Holets H. M., Chawla S., Flores J. V., Pruitt K. D., Carsrud N. D. V., McKee D., Okpo N. C., Jomsky B. M., Azi C. I., Quercetin: Exploring its unique flavonol properties, bioavailability, safety profile, and therapeutic potential in high-impact medical conditions, European Journal of Medical Research, 2024, 2, s. 178–198.
[20] Sanchez-Diaz L., Espinosa-Sanchez A., Blanco J. R., Carnero A., Senotherapeutics in cancer and HIV, Cells, 2022, 11(7), s.1222.
[21] Deepika D., Maurya P. K., Health benefits of quercetin in age-related diseases, Molecules, 2022, 27(8), s. 2498.
[22] Wang G., Wang, Y., Yao, L., Gu, W., Zhao, S., Shen, Z., Lin, Z., Liu, W., Yan, T., Pharmacological activity of quercetin: An updated review, Evidence-Based Complementary and Alternative Medicine, 2022, s. 3997190.
[23] Giuliani C., Di Dalmazi G., Bucci I., Napolitano G., Quercetin and thyroid, Antioxidants (Basel), 2024, 13(10), s. 1202.
[24] Andres S., Pevny S., Ziegenhagen R., Bakhiya N., Schäfer B., Hirsch-Ernst K.I., Lampen A., Safety aspects of the use of quercetin as a dietary supplement, Molecular Nutrition & Food Research, 2018, 62, s. 17000447.
[25] Williamson G., Clifford M. N., A critical examination of human data for the biological activity of quercetin and its phase-2 conjugates, Critical Reviews in Food Science and Nutrition, 2024, 8, s. 1–37.
[26] Karta charakterystyki, Resweratrol, Sigma-Aldrich, Merck Life Science sp. z o.o. Poznań 2024, s. 1–13.
[27] Takaoka M., Resveratrol: A new phenolic compound, from Veratrum grandiflorum, Journal of Japan Society of Chemistry, 1939, 60, s. 1090–1100.
[28] Burns J., McMichael R. W., Hendrix K. W., Plant foods and herbal sources of resveratrol, Journal of Agricultural and Food Chemistry, 2002, 50(11), s. 3337–3340.
[29] Sanders T. H., McMichael R. W., Hendrix K. W., Occurrence of resveratrol in edible peanuts, Journal of Agricultural and Food Chemistry, 2000, 48 (4), s. 1243–1246.
[30] Hung C-H., Chen S-D., Study of inducing factors on resveratrol and antioxidant content in germinated peanuts, Molecules, 2022, 27, s. 5700.
[31] Lee S., Kim M., Chun J., Cheong Y. K., Lee J., Analysis of trans-resveratrol in peanuts and peanut butters consumed in Korea, Food Research International, 2004, 37, s. 247–251.
[32] Wang C., Liu X., Zhang M., Shao H., Zhang M., Wang X., Wang Q., Bao Z., Fan X., Li H., Efficient enzyme-assisted extraction and conversion of polydatin to resveratrol from Polygonum cuspidatum using thermostable cellulase and immobilized β-glucosidase,
Frontiers in Microbiology, 2019, 10, s. 445.
[33] Monmai C., Kim J. S., Baek S. H., Use of germination to enhance resveratrol content and its anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7, Cells, Molecules, 2023, 28, s. 4898.
[34] Ragab A. S., Van Fleet J., Jankowski B., Park J. H., Bobzin S. C.,Detection and quantitation of resveratrol in tomato fruit (Lycopersicon esculentum Mill.), Journal of Agricultural and Food Chemistry, 2006, 54(19), s. 7175.
[35] Rozporządzenie Wykonawcze Komisji (UE) 2022/672 z dn. 22 kwietnia 2022 r. zmieniające rozporządzenie wykonawcze (UE) 2017/2470 w odniesieniu do specyfikacji nowej żywności trans-resweratrol (ze źródła mikrobiologicznego).
[36] Lephart E. D., Resveratrol, 4’ acetoxy resveratrol, R-equol, racemic equol or S-equol as cosmeceuticals to improve skin health, International Journal of Molecular Sciences, 2017, 18, s. 119.
[37] Lippi G., Franchini M., Favaloro E. J., Targher G., Moderate red wine consumption and cardiovascular disease risk: Beyond the “French paradox”, Seminars in Thrombosis and Hemostasis, 2010, 36, s. 59–70.
[38] Weiskirchen S., Weiskirchen R., Resveratrol: How much wine do you have to drink to stay healthy? Advances of Nutrition, 2016, 15, s. 706–718.
[39] Semba R. D., Ferrucci L., Bartali B., Urpí-Sarda M., Zamora-Ros R., Sun K., Cherubini A., Bandinelli S., Andres-Lacueva C., Resveratrol levels and all-cause mortality in older community-dwelling adults, JAMA Internal Medicine, 2014, 174, s. 1077–1084.
[40] Fernández-Mar M., Mateos R, García-Parrilla M. C, Puertas B., Cantos-Villar E., Bioactive compounds in wine: Resveratrol, hydroxytyrosol and melatonin: A review, Food Chemistry, 2012, 130, s. 797–813.
[41] Norata G. D., Marchesi P., Passamonti S., Pirillo A., Violi F., Catapano A. L., Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice, Atherosclerosis, 2007,191, s. 265–712.
[42] Ren B., Kwah M. X., Liu C., Ma Z., Shanmugam M. K., Ding L., Xiang X., Ho P. C.,Wang L., Ong P. S., Goh B. C., Resveratrol for cancer therapy: Challenges and future perspective, Cancer Letters, 2021, 515, s. 63–72.
[43] Walle T., Bioavailability of resveratrol, Annals of the New York Academy of Sciences, 2011, 1215, s. 9–15.
[44] Kaur G., Kaur R., Sodhi G.K., George N., Rath S.K., Walia H.K., Dwibedi V., Saxena S., Stilbenes: A journey from folklore to pharmaceutical innovation, Archiv of Microbiology, 2024, 206(5), s. 229.
[45] Raj P., Thandapilly S.J., Wigle J., Zieroth S., Netticadan T.A., comprehensive analysis of the efficacy of resveratrol in atherosclerotic cardiovascular disease, Myocardial Infarction and Heart Failure, Molecules, 2021, 26(21), s. 6600.
[46] Guarente L., Sinclair D.A., Kroemer G., Human trials exploring anti-aging medicines,
Cell Metabolism, 2024, 36(2), s. 354–376.
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