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HERBALISM

Bakuchiol: retinol’s successor
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Bakuchiol: retinol’s successor

Authors

  • Mateusz Grzelecki Koło Naukowe „Free Radicals” przy Zakładzie Chemii Fizycznej, Wydział Farmaceutyczny, WUM
  • Natalia Tyburc Koło Naukowe „Free Radicals” przy Zakładzie Chemii Fizycznej, Wydział Farmaceutyczny, WUM
  • Katarzyna Paradowska Katedra Farmacji Fizycznej i Bioanalizy, Zakład Chemii Fizycznej, Wydział Farmaceutyczny, WUM

DOI:

https://doi.org/10.12775/HERB.2021.009

Keywords

bakuchiol, Psolarea corylifolia, skin photoaging, retinol, retinoids

Abstract

Wrinkles and discolorations are visible effect of skin photoaging, whose mechanisms were discussed in this paper. Retinol, compound known in dermatology were used to treat acne, was used in topical application to prevent skin aging effects. Huge disadvantage of retinol therapy are its side effects including sun induced skin irritation. Search for replacement for retinol has brought bakuchiol, meroterpene acquired from Psolarea corylifolia. Bakuchiol, besides discussed in paper mechanism typical for retinoids, has antioxidant properties, which are additional mechanism of action against photoaging effects. This paper compares properties of bakuchiol and retinol as compounds used topically in cosmetology.

References

Glass G.E., Cosmeceuticals: The Principles and Practice of Skin Rejuvenation by Nonprescription Topical Therapy, Aesthetic Surgery Journal Open Forum, 2020, 2(4), s. 1–16.

Fisher G,J, Voorhees J.J., Molecular mechanisms of retinoid actions in skin. FASEB Journal, 1996,10(9), s. 1002–1013.

Kong R., Cui Y., Fisher G.J., Wang X., Chen Y., Schneider L.M., Majmudar G., A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin, Journal of Cosmetic Dermatology, 2016, 15(1), s. 49–57.

Kang S., Duell E.A., Fisher G.J., Datta S.C., Wang Z.Q., Reddy A.P., Tavakkol A., Yi J.Y., Griffiths C.E., Elder J.T., Voorhees J.J., Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation, Journal of Investigative Dermatologym, 1995, 105(4), s. 549–556.

Pathak J., Acharya R., BĀKUCĪ (Psoralea corylifolia L.) and its classical Ayurvedic and ethnomedicinal uses: A critical review, International Journal of Research in Ayurveda and Pharmac, 2018, 9(4), s.125–135.

Ruan B., Kong L.Y., Takaya Y., Niwa M., Studies on the chemical constituents of Psoralea corylifolia L, Journal of Asian Natural Products Research, 2007, 9(1), s. 41–44.

Yao S., Yang B., Xu Z., [Determination of bakuchiol in the fruit of Psoralea corylifolia L]. Zhongguo Zhong Yao Za Zhi. 1995, 20(11), s. 681–3, 704.

Gottumukkala Venkateswara R., Kandaswamy K., Manathusamy G., Triptikumar M., Isolation, and characterization of a potent antimicrobial compound from Aervasanguinolenta Blume, An alternative source of Bakuchiol, Journal of Pharmacy Research,

, 5(1), s. 174–176.

Ohno O., Watabe T., Nakamura K., Kawagoshi M., Uotsu N., Chiba T., Yamada M., Yamaguchi K., Yamada K., Miyamoto K., Uemura D., Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells, Bioscience, Biotechnology and Biochemistry, 2010, 74(7), s. 1504–1506.

Choi S.Y., Lee S., Choi W.H., Lee Y., Jo Y.O., Ha T.Y., Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica, Journal of Medicinal Food, 2010, 13(4), s. 1019–1023.

Krenisky J.M., Luo J., Reed M.J., Carney J.R., Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes, Biological and Pharmaceutical Bulletin, 1999, 22(10), s. 1137–1140.

Lystvan K., Belokurova V., Sheludko Y., Ingham J., Prykhodko V., Kishchenko O., Paton E., Kuchuk N., Production of bakuchiol by in vitro systems of Psoralea drupacea Bge, Plant Cell, Tissue and Organ Culture (PCTOC), 2009, 101, s. 99–103.

Backhouse C.N., Delporte C.L., Negrete R.E., Erazo S., Zuñiga A., Pinto A., Cassels B.K., Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities, Journal of Ethnopharmacology, 2001, 78(1), s. 27–31.

Hsu P.J., Miller J.S., Berger J., Bakuchiol, an antibacterial component of Psoralidium tenuiflorum, Natural Product Research, 2009, 23, s. 781–788.

Mehta G., Ramdas Nayak U., Dev S., Bakuchiol, a novel monoterpenoid, Tetrahedron Letters, 1966, 7(38), s. 4561–4567.

Prakasa Rao A.S.C., Bhalla V.K., Nayak U.R., Dev S., Meroterpenoids—II: Psoralea corylifolia Linn. – 2. Absolute configuration of (+)-bakuchiol, Tetrahedron, 1973, 29(8), s. 1127–1130.

Banerji A., Chintalwar G.J., Biosynthesis of bakuchiol from cinnamic and p-coumaric acids, Phytochemistry, 1984, 23(8), s. 1605–1606,

Dhaliwal S., Rybak I., Ellis S.R., Notay M., Trivedi M., Burney W., Vaughn A.R., Nguyen M., Reiter P., Bosanac S., Yan, H., Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing, British Journal of Dermatology,

, 180(2), s. 289–296.

Gunt H., Draelos Z.D., Levy S.B., Topical effects of a natural retinol alternative: A clinical assessment of bakuchiol on sensitive skin, Journal of the American Academy of Dermatology, 2020, 83(6), s. AB171.

Adhau A., Pardeshi M., Bakuchiol: A Retinol like Structure in the Field of Cosmetics, International Journal of Advance Study and Research Work, 2020, 3(7), s. 14–18.

Poláková K., Fauger A., Sayag M., Jourdan E., A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial, Clinical, Cosmetic and Investigational Dermatology, 2015, 10(8), s. 187–191.

Chaudhuri R., Bakuchiol: A Retinol-Like Functional Compound, Modulating Multiple Retinol and Non-Retinol Targets., Cosmeceuticals and Active Cosmetics, Third edition, Boonton USA, 2015, s. 1–18.

Narda M., Brown A., Granger C., A 3-in-1-night facial serum containing melatonin, bakuchiol, and vitamin C restores the homeostatic properties of photoaged skin by activating hypoxia-inducible factor 1 signaling, Journal of the American Academy of Dermatology, 2020, 83, s. AB10.

Adhikari S., Joshi R., Patro B.S., Ghanty T.K., Chintalwar G.J., Sharma A., Chattopadhyay S., Mukherjee T., Antioxidant activity of bakuchiol: experimental evidence and theoretical treatments on the possible involvement of the terpenoid chain, Chemical Research in Toxicology, 2003, 16(9), s. 1062–1069.

Haraguchi H., Inoue J., Tamura Y., Mizutani K., Inhibition of Mitochondrial Lipid Peroxidation by Bakuchiol, a Meroterpene from Psoralea corylifolia, Planta Medica, 2000, 66(6), s. 569–571.

Narda M., Brown A., Muscatelli-Groux B., Grimaud J.A., Granger C., Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies. Dermatol Ther (Heidelb). 2020, 10(1), s. 191–202.

Poláková K., Fauger A., Sayag M., Jourdan E., Adermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: Result from a controlled randomized trial, Clinical, Cosmetic and Investigational Dermatology, 2015, 8, s. 187–191.

Trompezinski S., Weber S., Cadars B., Larue F., Ardiet N., Chavagnac-Bonneville M., Sayag M., Jourdan E., Assessment of a new biological complex efficacy on dysseborrhea, inflammation, and Propionibacterium acnes proliferation, Clinical, Cosmetic and Investigational Dermatology, 2016, 9, s. 233–239.

Chaudhuri R., Marchio F., Bakuchiol in the management of acne-affected Skin, Cosmetics & Toiletries, 2011, 126, s. 502–510.

Bacqueville D., Maret, A., Noizet M., Duprat L., Coutanceau C.,Georgescu V., Bessou-Touya, S., Duplan, H., Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin. Clinical, Cosmetic and Investigational Dermatology, 2020, 13, s. 359–370.

HERBALISM

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Published

2023-05-10

How to Cite

1.
GRZELECKI, Mateusz, TYBURC, Natalia and PARADOWSKA, Katarzyna. Bakuchiol: retinol’s successor. HERBALISM. Online. 10 May 2023. Vol. 7, no. 1, pp. 129-142. [Accessed 17 January 2026]. DOI 10.12775/HERB.2021.009.
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