Bakuchiol: następca retinolu
DOI:
https://doi.org/10.12775/HERB.2021.009Klíčová slova
bakuchiol, Psolarea corylifolia, fotostarzenie skóry, retinol, retinoidyAbstrakt
Zmarszczki i przebarwienia to widoczne skutki fotostarzenia skóry, którego mechanizmy omówiono pokrótce w poniżej pracy. Dotychczas do zwalczania jego skutków używano aplikowany miejscowo retinol, znany w dermatologii związek, stosowany z powodzeniem w leczeniu trądziku. Dużym minusem terapii retinolem są występujące skutki uboczne, m.in. podrażnienia wywołane ekspozycją skóry na światło słoneczne. Poszukiwania zamiennika retinolu o ograniczonych skutkach ubocznych przyniosły rezultat w postaci bakuchiolu, meroterpenu pozyskiwanego z Psolarea corylifolia. Bakuchiol, oprócz omówionych w pracy mechanizmów działania typowych dla retinoidów, przejawia właściwości antyoksydacyjne, co stanowi dodatkowy mechanizm walki ze skutkami fotostarzenia. Praca stanowi przegląd wiadomości i porównanie podstawowych właściwości retinolu i bakuchiolu jako związków stosowanych miejscowo na skórę w kosmetologii.
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