Effect of hesperidin on the development of oxidative stress in the heart of type 1 diabetic rats
DOI:
https://doi.org/10.12775/HERB.2023.004Keywords
type 1 diabetes, hesperidin, oxidative stress, heartAbstract
In the course of diabetes, hyperglycemia is observed, which is one of the reasons for the development of oxidative stress that damages various tissues and organs of the body, including the heart. Supplementation of plant-derived compounds with antioxidant properties can be an effective method of preventing oxidative stress. In this study, the effect of the flavonoid hesperidin on the oxidative stress parameters in the heart tissue in the course of type 1 diabetes was determined. For this purpose,
hesperidin at the doses of 50 and 100 mg/kg was administered per os for 28 days to male Wistar rats, in which diabetes was induced by an intraperitoneal injection streptozotocin. Diabetic rodents showed an increase in the catalase, glutathione peroxidase activities and dimalonaldehyde content in the hearts. The use of hesperidin at both doses resulted in a decrease in the activity of superoxide dismutase, a decrease in the content of dimalonaldehyde, while the higher dose of this flavonoid also resulted in a decrease in the total oxidative status combined with an increase in the total antioxidant response. It can be concluded that hesperidin alleviates redox imbalances in heart tissue in the course of type 1 diabetes.
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