Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Characteristics of changes in the structural components of the mucosa and rat laryngeal cartilage at the end of the third week of experimental opioid exposure
  • Home
  • /
  • Characteristics of changes in the structural components of the mucosa and rat laryngeal cartilage at the end of the third week of experimental opioid exposure
  1. Home /
  2. Archives /
  3. Vol. 11 No. 4 (2021) /
  4. Research Articles

Characteristics of changes in the structural components of the mucosa and rat laryngeal cartilage at the end of the third week of experimental opioid exposure

Authors

  • K. P. Ivasivka Danylo Halytsky Lviv National Medical University
  • E. V. Paltov Danylo Halytsky Lviv National Medical University
  • Z. Z. Masna Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.12775/JEHS.2021.11.04.007

Keywords

opioid, laryngeal mucosa, laryngeal cartilage, rat, early terms

Abstract

In our work we aimed to study the pathomorphological manifestations among the structural components of the laryngeal mucosa and cartilage in the early stages of the experimental opioid effect. This goal was achieved through the use of histological techniques to visualize the structural components of the laryngeal mucosa and cartilage. Histological sections with a thickness of 5 - 7 mm were made. Histological specimens were prepared according to conventional methods using the dye hematoxylin, eosin, azan according to the method of Heidenhain, PAS-reaction according to Mc-Manus and Alcian blue according to Steedman. Microscopic examinations and photographing of the preparations were performed using an MBI-1 microscope and a Nicon D 3100 digital camera.

At the microstructural level after 21 days in rats there was an increase in dyscirculatory changes, which were most pronounced in the vessels of the lamina propria of the laryngeal mucosa. The epithelial layer of the epiglottis was inhomogeneously thickened, especially on the pharyngeal surface. Small polymorphonuclear infiltrates were found in the laryngeal mucosa of the epiglottis. The vessels of the laryngeal ventricular mucosa of the larynx were dilated and filled with erythrocytes. The development of perivascular edema was registered. In the areas of transudate accumulation, the main substance of the laryngeal mucosa of the larynx was enlightened. Necrotic changes developed in the epitheliocytes of the laryngeal ventricle. Eosinophilic mass accumulated on the surface of the ventricular mucosa.

The results of the study in the future will form a pathomorphological base that can be used for comparative characterization of the dynamics of growth of pathomorphological changes in the structural components of the laryngeal mucosa and cartilage in the early stages and compare these changes with pathomorphological manifestations in the late stages of experimental opioid exposure.

References

Radomsky VT, Seryogina NM Diskovsky IS. Features of the microstructure of rat skin under opioid exposure. Experimental and clinical medicine. 2014. № 3. P.61–64.

Tabachnikov SI, Lebedev DS, Trofimchuk GE. [etc.] Epidemiological situation regarding the use of psychoactive substances in Ukraine. Archive of psychiatry. 2009. T. 15. № 1 (56). P.81–88.

Clausen T, Anchersen K, Waal H. Mortality prior to, during and after opioid maintenance treatment (OMT): a national prospective cross-registry study. Drug Alc. Dep. 2010. Vol. 94, № 1. P.151–157.

Akshat S, Ramachandran R, Rewari V. [et al.] Morphine versus Nalbuphine for open gynecological surgery: a randomized controlled double blinded trial [Electronic resource] Pain Res. Treat. 2014. Access mode: http://www.hindawi.com/journals/prt/2014/727952/.

Schnabel A, Reichl SU, Zahn PK. [et al.] Nalbuphine for postoperative pain treatment in children [Electronic resource]. Cochr. Lib. 2014. Access mode: http://onlinelibrary.wiley.com/doi/10.1002/ 14651858.CD009583.pub2 / full.

Y. Paltov, Kryvko. Y., V. Fik, Soguyko Yu. K. Voitsenko, Ivasivka H, Pankiv M, K. Morphological changes on the retina layers during the twoweek effect of an opioid analgesic Natural Science Readings abstracts booc (May 18 - 21, 2017, Bratislava). - p. 79 - 80.

Paltov EV, Fik VB, Krivko Yu.Ya. Dynamics of morphological changes in the retinal layers at the end of the sixth week of opioid influence INNOVATIVE TECHNOLOGY IN MEDICINE: EXPERIENCE OF POLAND AND UKRAINE .- Lublin Republic of Poland .- April 2017.- 28 - 29.– p. 120 - 123.

Paltov EV, Kovalishin VI, Fik VB, Krivko Yu.Ya., Pankevich LV Manifestations of pathomorphological changes in the retinal layers after ten weeks of opioid exposure in the experiment World of Medicine and Biology.- № 4 (66). - 2018. - P. 185 - 187.

E. V. Paltov,Yu. Ya. Kryvko., Zhukovskyi V.S,Fik V. B, I. V. Vilkhova,Pankiv M, V. Pathomorphologic changes in the retina layers at the end of the fourth week of effect. Deutscher Wissenschaftsherold. German Science Herald . – 2018. – №4. – p. 36 – 39.

Paltov E. V., Kovalyshyn O. A., Fik V. B., Kryvko Y. Ya., Podoliuk M. V., Holeyko M. V. PATHOMORPHOLOGICAL CHANGES IN RATS' RETINAL LAYERS AT THE END OF THE TWELFTH WEEK OF EXPERIMENTAL OPIOID INFLUENCE. International Academy Journal Web of Scholar 4(34) April 2019 С. 19-22.

E.V. Paltov., OA Kovalishin., VB Fik., MV Podolyuk., Goleyko MV, Yu.Ya. Crooked. Dynamics of pathomorphological changes in the retinal layers due to a two-week opioid effect with subsequent opioid withdrawal and four-week correction in the experiment. WORLD SCIENCE / - №11 (51) Vol. 2, November. 2019. - P. 34- 39.

Paltov EV Characteristics of pathomorphological changes in the retinal layers during six weeks of opioid analgesic use with parallel four-week correction with pentoxphylline. PROBLEMS AND PERSPECTIVES OF MODERN SCIENCE AND PRACTICE. ABSTRACTS OF I INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE GRAZ, AUSTRIA. - 30 - 31, JANUARY. - 2020.- C. 201 - 204.

Paltov EV, Kovalskaya ME Disorganization changes in the retinal layers of rats at the end of the fourteenth week of experimental opioid effects International scientific - practical conference. Medical sciences: directions and tendencies of development in Ukraine and the world. Odessa. June 19 - 20, 2020 - pp. 86 - 92.

Narver HL. Nalbuphine, a non-controlled opioid analgesic, and its potential use in research mice. Lab. An. 2015. Vol. 44, № 3. P. 106– 110.

Copeland L, Robertson J, McKenzie J. [et al.]Premature mortality in Scottish injecting drug users: a life-history approach. Scott. Med. J. 2012. Vol. 57. P. 59-65.

Deering D, Sellman JD, Adamson S. Opioid substitution treatment in New Zealand: a 40 year perspective. N Z Med J Online.2014;127(1397):57–66.

Tabachnikov SI, Vievsky AM, Zhdanova MP. Clinical features and leading factors of substance use in children and adolescents in the light of the development of a comprehensive multilevel system of its medical and social correction and prevention Ukrainian Journal of Clinical and Laboratory Medicine. 2012. T. 7, № 1. S.4–10.

Litvintsev BS. Structural and functional changes of the nervous system in chronic opioid poisoning: author's ref. dis. at the request of a scientist. Ph.D. honey. Sciences: [spec.] 14.00.18 "Psychiatry" M., 2003. 23p.

Pat. №76564 U Ukraine, IPC A 61 K 31/00 Method of modeling physical opioid dependence in rats / applicants: Onysko RM, Paltov EV, Fik VB, Vilkhova IV, Kryvko Yu.Ya. ., Yakymiv N.Ya., Fitkalo OS; patent owner: Danylo Halytskyi Lviv National Medical University. - 201u201207124; declared 12.06.2012; publ. 10.01.2013, Bull. №1.

Romeis B. Microscopic technique. M .: Medicine, 1953.–p. 71 - 72.

Goralsky LP, Khomich VT, Kononsky OI Edited by Goralsky LP Fundamentals of histological technique and morphofunctional research methods in normal and pathology. Tutorial. Kind. III, corrected and supplemented. Zhytomyr: Polissya, 2015. 286 p.

Downloads

  • PDF

Published

2021-04-27

How to Cite

1.
IVASIVKA, K. P., PALTOV, E. V. and MASNA, Z. Z. Characteristics of changes in the structural components of the mucosa and rat laryngeal cartilage at the end of the third week of experimental opioid exposure. Journal of Education, Health and Sport. Online. 27 April 2021. Vol. 11, no. 4, pp. 58-71. [Accessed 7 July 2025]. DOI 10.12775/JEHS.2021.11.04.007.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 11 No. 4 (2021)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 583
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

opioid, laryngeal mucosa, laryngeal cartilage, rat, early terms
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop