Journal of Education, Health and Sport

Aim. To compare the nephroprotective effect of oral applications of different phytogels in experimental kidney pathology.

Methods. We used phytogels: "Kvertulin" (quercetin + inulin + calcium citrate), "Biotrit" (juice from wheat germ) and "Dubovy" (extract from oak wood).

Experimental models were reproduced in rats: diabetic syndrome, prednisolone immunodeficiency, intoxication with thermal peroxide sunflower oil. The condition of the kidneys was assessed by changes in the level of biochemical markers in the kidney tissue (elastase, urease, lysozyme, MDA, the degree of dysbiosis).

Results. Experimental pathologies cause an increase in the level of elastase, urease, MDA, the degree of dysbiosis, and a decrease in lysozyme activity in the kidneys. Oral application of phytogels caused a decrease in the activity of elastase, urease, MDA content and the degree of dysbiosis, but increased the activity of lysozyme. When recalculating the degree of decrease in elastase activity and increase in lysozyme activity per 1 g of phytogel or 1 mg of active principle (quercetin or the amounts of polyphenols), phytogel "Kvertulin" turned out to be the most effective anti-elastase agent, and phytogel "Biotrit" turned out to be the most effective lysozyme-reducing agent.

Conclusion. Oral applications of multifunctional mucous-adhesive gels have a nephroprotective effect in experimental kidney pathology.

Stepan VT. Therapeutic and prophylactic effects of the mucous-adhesive gel "Kvertulin" on the kidneys of rats treated with oral applications of peroxide sunflower oil. Dentistry Bulletin. 2019; 10 (special issue): 31-37. (in Ukrainian)

Stepan VT. Influence of Dubovy phytogel on the kidney condition of rats treated with oral applications of peroxide sunflower oil. Surgery of Donbass.2019; 8(2): 50-55. (in Ukrainian)

Stepan VT. The effect of oral applications of phytogel "Kvertulin" on the biochemical parameters of the kidneys of rats with experimental dysbiotic syndrome. Bukovynian Medical Bulletin. 2020; 24(3(95): 102-107. (in Ukrainian)

Stepan VT. Renoprotective action of mucous-adhesive phytogel "Biotrit" in rats, treated with oral application peroxide sunflower oil. Journal of Education, Health and Sport. 2020; 10(11): 89-95.

Levitsky AP. Stomatogenic endotoxinemia. Journal of the National Academy of Medical Sciences of Ukraine. 2013; 19(4): 490-493. (in Russian)

Levitsky A. P. The use of antidysbiotic preparations in dentistry. Dentistry Bulletin. 2014; 4(89): 89-92. (in Russian)

Levitsky AP, Demyanenko SA, Tsiselskiy YuV. The antimicrobic function of liver. Оdеssа, KP OGT, 2011:141. (in Russian)

Levitsky AP, Makarenko OA, Selivanskaya IA [and others]. «Querthulin», Vitamin P, prebiotic, hepatoprotector.Оdеssа, KP OGT, 2012: 20. (in Russian)

Levitsky AP. Inulin as food for bacteria and medicine for people. Odessa, KP OGT, 2003: 28. (in Russian)

Demyanenko SA. Mucoprotective and hepatoprotective properties of wheat germ. Dentistry Bulletin. 2008; 5-6: 10-14. (in Russian)

Levitsky AP, Makarenko OA, Khodakov IV [and others]. Hepatoprotective properties of polyphenols substances of Oak extract. Journal of Education, Health and Sport. 2016; 6(11): 537-547.

Stepan VT, Pustovoyt IP. The effect of phytopreparations on the biochemical parameters of the kidneys of rats with prednisolone immunodeficiency. Bulletin of Marine Medicine. 2015; 2(67): 87-93. (in Ukrainian)

Levitsky AP. Gozhenko AI, Stepan VT [and others]. Biochemical markers of inflammatory-dystrophic and dysbiotic processes in the kidneys of rats in experimental pathology: guidelines. Odessa, 2020: 17. (in Ukrainian)

Truhacheva NV. Mathematical Statistics in biomedical research using application package Statistica. Moskow, GJeOTAR-Media, 2012: 379. (in Russian)