Forecast and clinical-diagnostic significance of increased expression of beta-2microglobulin in the urine in the process of nephropathy formation in essential hypertension

R. L. Kulynych, D. G. Rekalov

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.12.007

Abstract


Introduction. At present, it is obvious that the prognosis for the life of patients with essential hypertension, according to the cardiovascular continuum, is clearly determined primarily by the involvement in the pathological process of target organs and the severity of their structural and functional changes.

The aim of the study is to identify the clinical-diagnostic and prognostic value of B2-MGU as a marker of kidney damage in essential hypertension.

Materials and methods. To achieve this goal, 46 patients with essential hypertension (45.65% women and 54.35% men) aged from 28 to 71 years (mean age was 51.88 ± 2.17 years), I-II stage of the disease with level of hypertension I-III degree, varying degrees of risk, who did not receive systematic adequate antihypertensive therapy and in which as a result of comprehensive clinical, laboratory and instrumental studies there were no evidence of clinically significant chronic kidney disease. The control group consisted of 17 healthy individuals.

Results. In patients with essential hypertension is forming hypertensive nephropathy, which is characterized by statistically significant excessive excretion of beta-2-microglobulin in the urine compared with almost healthy individuals. In patients with increased excretion of beta-2-microglobulin violations of intrarenal hemodynamics were registered significantly more often, violations of functional renal reserve, violations of vascular resistance of renal vessels, in a significantly higher percentage there were pathological changes in circadian rhythm of blood pressure and renal filtration function, the prevalence of concentric and eccentric hypertrophy, proteinuria, which indicates an important clinical, diagnostic and prognostic value of hyper-beta-2-microglobulinuria.

Conclusions. The indicator beta-2-microglobulinuria can be used as an adequate marker of hypertensive nephropathy, as having high sensitivity, specificity, positive and negative prognosis.


Keywords


glomerular filtration rate; functional renal reserve; hypertensive nephropathy; urinary albumin excretion; beta-2-microglobulinuria

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References


Ku E, Lee BJ, Wei J, Weir MR. Hypertension in CKD: Core Curriculum 2019. Am J Kidney Dis. 2019 Jul;74(1):120-131. doi: 10.1053/j.ajkd.2018.12.044. Epub 2019 Mar 19. PMID: 30898362.

Freedman BI, Cohen AH. Hypertension-attributed nephropathy: what's in a name? Nat Rev Nephrol. 2016 Jan;12(1):27-36. doi: 10.1038/nrneph.2015.172. Epub 2015 Nov 10. PMID: 26553514.

Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017 Nov;125(Pt A):21-38. doi: 10.1016/j.phrs.2017.06.005. Epub 2017 Jun 12. PMID: 28619367; PMCID: PMC5607101.

Girndt M. Diagnostik und Therapie der chronischen Nierenerkrankung [Diagnosis and treatment of chronic kidney disease]. Internist (Berl). 2017 Mar;58(3):243-256. German. doi: 10.1007/s00108-017-0195-2. PMID: 28194476.

Weisrock F, Fritschka M, Beckmann S, Litmeier S, Wagner J, Tahirovic E, Radenovic S, Zelenak C, Hashemi D, Busjahn A, Krahn T, Pieske B, Dinh W, Düngen HD. Reliability of peripheral arterial tonometry in patients with heart failure, diabetic nephropathy and arterial hypertension. Vasc Med. 2017 Aug;22(4):292-300. doi: 10.1177/1358863X17706752. Epub 2017 May 30. PMID: 28555533.

Ruiz-Hurtado G, Ruilope LM. Microvascular injury and the kidney in hypertension. Hipertens Riesgo Vasc. 2018 Jan-Mar;35(1):24-29. doi: 10.1016/j.hipert.2017.03.002. Epub 2017 Apr 18. PMID: 28431922.

Sievers LK, Eckardt KU. Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension. Int J Mol Sci. 2019 Apr 30;20(9):2138. doi: 10.3390/ijms20092138. PMID: 31052201; PMCID: PMC6539752.

Boddi M. Renal Ultrasound (and Doppler Sonography) in Hypertension: An Update. Adv Exp Med Biol. 2017;956:191-208. doi: 10.1007/5584_2016_170. PMID: 27966109.

Wang Y, Wang C, Zhang X, Gu HF, Wu L. Common Drugs for Stabilization of Renal Function in the Progression of Diabetic Nephropathy and Their Relations with Hypertension Therapy. Curr Diabetes Rev. 2018;14(2):149-161. doi: 10.2174/1573399813666170214112115. PMID: 28201968.

Tirapani LDS, Fernandes NMDS. A narrative review of the impacts of income, education, and ethnicity on arterial hypertension, diabetes mellitus, and chronic kidney disease in the world. Saudi J Kidney Dis Transpl. 2019 Sep-Oct;30(5):1084-1096. doi: 10.4103/1319-2442.270264. PMID: 31696847.

Yang C, Wang H, Zhao X, Matsushita K, Coresh J, Zhang L, Zhao MH. CKD in China: Evolving Spectrum and Public Health Implications. Am J Kidney Dis. 2020 Aug;76(2):258-264. doi: 10.1053/j.ajkd.2019.05.032. Epub 2019 Sep 3. PMID: 31492486.

Sternlicht H, Bakris GL. The Kidney in Hypertension. Med Clin North Am. 2017 Jan;101(1):207-217. doi: 10.1016/j.mcna.2016.08.001. PMID: 27884230.

Robinson TW, Freedman BI. The Impact of APOL1 on Chronic Kidney Disease and Hypertension. Adv Chronic Kidney Dis. 2019 Mar;26(2):131-136. doi: 10.1053/j.ackd.2019.01.003. PMID: 31023447; PMCID: PMC6601639.

Culver S, Li C, Siragy HM. Intrarenal Angiotensin-Converting Enzyme: the Old and the New. Curr Hypertens Rep. 2017 Sep 19;19(10):80. doi: 10.1007/s11906-017-0778-2. PMID: 28929450; PMCID: PMC5913745.

Kotsis V. Treatment of Hypertension Induced Target Organ Damage. Curr Pharm Des. 2018;24(37):4377. doi: 10.2174/138161282437190227103636. PMID: 30885112.

Kim CS, Choi HS, Bae EH, Kim SW, Ma SK. Optimal blood pressure target and measurement in patients with chronic kidney disease. Korean J Intern Med. 2019 Nov;34(6):1181-1187. doi: 10.3904/kjim.2019.164. Epub 2019 Jun 17. PMID: 31189302; PMCID: PMC6823567.

Quimby JM. Update on Medical Management of Clinical Manifestations of Chronic Kidney Disease. Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1163-81. doi: 10.1016/j.cvsm.2016.06.004. PMID: 27593576.

Emrich IE, Böhm M, Mahfoud F. The 2018 ESC/ESH Guidelines for the management of arterial hypertension: A German point of view. Eur Heart J. 2019 Jun 14;40(23):1830-1831. doi: 10.1093/eurheartj/ehz381. PMID: 31199493.

Mukoyama M, Adachi M. [Kidney and hypertension]. Nihon Jinzo Gakkai Shi. 2016;58(1):26-32. Japanese. PMID: 26950978.

Costache II, Costea CF, Fotea V, Rusu VL, Aursulesei V, Al Namat R, Costache DA, Dumitrescu N, Buzdugă CM, Dumitrescu GF, Sava A, Bogdănici CM. Morphological and functional renovascular changes as cause of resistant arterial hypertension - case report and literature review. Rom J Morphol Embryol. 2018;59(1):323-328. PMID: 29940645.

Fouad M, Fathy H, Zidan A. Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients. J Bras Nefrol. 2016 Dec;38(4):403-410. Portuguese, English. doi: 10.5935/0101-2800.20160065. PMID: 28001185.

Kaltsatou A. Management of Blood Pressure and Heart Rate in Chronic Kidney Disease. Curr Pharm Des. 2017;23(31):4603-4608. doi: 10.2174/1381612823666170829164305. PMID: 28875847.

Di Nicolò P. The dark side of the kidney in cardio-renal syndrome: renal venous hypertension and congestive kidney failure. Heart Fail Rev. 2018 Mar;23(2):291-302. doi: 10.1007/s10741-018-9673-4. PMID: 29383636.

Isaacs AN, Vincent A. Antihypertensive therapy for the prevention of nephropathy in diabetic hypertensive patients. J Clin Pharm Ther. 2016 Apr;41(2):111-5. doi: 10.1111/jcpt.12361. Epub 2016 Feb 6. PMID: 26850093.

Andrikou I, Tsioufis C, Konstantinidis D, Kasiakogias A, Dimitriadis K, Leontsinis I, Andrikou E, Sanidas E, Kallikazaros I, Tousoulis D. Renal resistive index in hypertensive patients. J Clin Hypertens (Greenwich). 2018 Dec;20(12):1739-1744. doi: 10.1111/jch.13410. Epub 2018 Oct 25. PMID: 30362245.

Dojki FK, Bakris GL. Blood Pressure Control and Cardiovascular/Renal Outcomes. Endocrinol Metab Clin North Am. 2018 Mar;47(1):175-184. doi: 10.1016/j.ecl.2017.10.008. PMID: 29407050.


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