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Journal of Education, Health and Sport

Study of reduction of antioxidant protection in the pathogenesis of experimental diabetic retinopathy
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  • Study of reduction of antioxidant protection in the pathogenesis of experimental diabetic retinopathy
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Study of reduction of antioxidant protection in the pathogenesis of experimental diabetic retinopathy

Authors

  • Ya. V. Sirman SE "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine"
  • N. I. Preys SE "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine"
  • I. V. Savytskyi SE "Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine"

DOI:

https://doi.org/10.12775/JEHS.2020.10.11.031

Keywords

diabetic retinopathy, diabetes mellitus, experimental model, oxidative stress, peroxidase

Abstract

The prevalence of diabetes mellitus (DM) is growing among the population of countries of the world, depending on the region, the level of economic development of the country, gender and age. The antioxidant system plays an important role in protecting the cells of the body from permanent and numerous damage that occurs due to the pathological influence of free radicals. Antioxidant enzymes, and peroxidases in particular, block the initiation of chain oxidation processes, preventing, among other things, the processes of DNA damage by free radicals that provoke the process of mutagenesis.

Our results indicate the development of oxidative stress in the pathogenesis of experimental diabetic retinopathy, as evidenced by a pronounced decrease in the activity of the antioxidant defense enzyme under the conditions of our study.

Already on the thirtieth day of the development of experimental diabetic retinopathy, a decrease in peroxidase activity was observed, followed by the progression of pathological changes on the sixtieth day of the study.

The most pronounced decrease in the activity of the studied marker of antioxidant defense was found at the 3rd stage of the experiment.

References

Tsitovsky MN Statistical, clinical and morphological aspects of the impact of diabetes on the state of the cardiovascular system. Scientific Bulletin of Uzhhorod University, series "Medicine". 2017. № 1 (55). Pp. 168–177.

Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches / R. Madonna et al. Vascul Pharmacol. 2017. № 90. R. 1–7.

Sorokina YuA, Lovtsova LV. Koeffitsienty okislitelnoho stressa kak sposob personifitsirovaniya farmakoterapii v debyute SD 2 tipa. Meditsina i farmakolohiya : elektron. nauchn. zhurn. [Internet] 2014; 1 (14). Available from: https://7universum.com/ru/med/archive/item/1868 (Russian).

Pasechnikova NV, Moroz OA. Issledovanie vliyaniya kvertsetina i lipoata na protsessy perekisnoho okisleniya lipidov v setchatke pri eksperimentalnom diabete. Oftalmolohicheskiy zhurnal. 2016; 4 (470):38-42 (Russian).

Pasechnikova NV, Naumenko VA, Zborovskaya AV. Sostoyanie hematoretinalnoho barera pri diabeticheskoy retinopatii po dannym flyuorometri. Oftalmolohichniy zhurnal. 2008; 5:4-7 (Russian).

Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog. In Neuro-Psychopharm. & Biol. Psych. 2003; 27:283-290.

Leus NF. Metabolicheskie mekhanizmy razvitiya i perspektivy medikamentoznoho lecheniya diabeticheskoy retinopatii. Oftalmolohichniy zhurnal. 2003; 5:75–80 (Russian).

Preclinical studies of drugs: a method. rivers / for ed. Corresponding Member NAMS of Ukraine, acad. OV Stefanova. К.: Avicenna, 2001. 528 с.

Biomarkers of diabetic retinopathy / MV Budzinskaya, DV Lipatov, VG Pavlov, DV Petrachkov // Diabetes mellitus. 2020. № 1 (23). Pp. 88–94.

Lupan IV, Avramenko OV, Akbash KS Computer statistical packages: a textbook. - 2nd type. - Kirovograd: "CODE" 2015. - 236 p.

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Published

2020-11-30

How to Cite

1.
SIRMAN, Ya. V., PREYS, N. I. and SAVYTSKYI, I. V. Study of reduction of antioxidant protection in the pathogenesis of experimental diabetic retinopathy. Journal of Education, Health and Sport. Online. 30 November 2020. Vol. 10, no. 11, pp. 306-311. [Accessed 5 July 2025]. DOI 10.12775/JEHS.2020.10.11.031.
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Issue

Vol. 10 No. 11 (2020)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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