Comparison of expenditure of using experimental models of carcinogenesis

I. V. Savytskyi, L. A. Ershova

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.11.017

Abstract


Despite significant advances in the diagnosis and treatment of oncopathology, the main epidemic indicators have a negative trend.

Based on the above, a very relevant topic is the development of experimental models of carcinogenesis. The importance of scientific work in this area is increasing because in experimental conditions it is better to test new methods, diagnostics and treatment. Thus, it becomes possible to study the peculiarities of the pathogenesis of any tumor at different stages.

The purpose of the work – to study and demonstrate the strengths and weaknesses of the main experimental models of carcinogenesis for further selection of the most appropriate.

Results The main directions of carcinogenesis modeling are presented in the article. Initially, the problem was justified. The next step is described in chronological order of using the models.

Of course, the achievements of clinical and experimental oncology played an important role in the emergence of models. Thus, the first model was the effect of physical and chemical carcinogens on a laboratory animal. The latest achievement of experimental oncology is the use of stem cells in combination with genetic engineering.

No less important is the fact of comparing experimental models. We present the strengths and weaknesses of all these models.

Conclusions

1. To date, there are a large number of experimental models of carcinogenesis.

2. When planning a study, you need to calculate all the goals to be achieved and select the appropriate model.

3. The most effective and common model for ascites ovarian tumor is the transplantation of atypical cells to laboratory animals.


Keywords


experimental models; carcinogenesis; rats

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