Predictors of adverse outcomes in preterm infants in the early neonatal period

O. V. Klishch, H. A. Pavlyshyn, K. V. Коzak, I. M. Sarapuk



Introduction. Extremely and very preterm infants are a special cohort of newborns with inherent functional immaturity and specific pathological conditions which are accompanied by hypoxia, reoxygenation, tissue hypoperfusion, increased risk of oxidative stress. Premature infants are prone to oxidative deterioration which plays a key role in the pathogenesis of severe diseases such as respiratory distress syndrome, necrotizing enterocolitis, periventricular leukomalacia, patent ductus arteriosus, bronchopulmonary dysplasia, and retinopathy of prematurity.

Objective. The aim of the research was to estimate the predictors of adverse outcomes in preterm infants with gestational age less than 32 weeks in the early neonatal period by assessment of oxidative stress markers.

Material and methods. A total amount of 46 preterm infants with gestational age less than 32 weeks in the early neonatal period were included in the research. According to the results of early outcomes newborns were divided into two groups: I group – 12 infants with adverse outcomes and II group - 34 preterm infants with favorable outcomes. Twenty healthy newborns were included in the control group (III group). Clinical examination of infants and laboratory determination of oxidative stress markers were done for all participants.

Results. Asphyxia, early onset sepsis, intraventricular hemorrhage in preterm infants less than 32 weeks of gestation had increased the risk of mortality in the early neonatal period. The level of 8-isoprostane, ROS, TBP, LHP was significantly higher in neonates with adverse outcomes (group I). It was found that the level of 8-isoprostane more than 595.4 mg/ml, ROS level above 0.483 IU, TBP higher than 5.14 μmol/l and LHP levels above 5.91 U/m were associated with unfavorable outcomes in the early neonatal period. Decreased activity of the antioxidant system (catalase, SOD) increases the risk of early neonatal mortality.

Conclusions. The activation of oxidative stress in preterm infants may be a predictor of adverse outcomes in the early neonatal period.


preterm infant; oxidative stress; early neonatal period; adverse outcomes; favorable outcomes

Full Text:



WHO; Howson C, Kinney M, Lawn J (Eds.). Born Too Soon: The Global Action Report on Preterm Birth. Geneva, Switzerland: World Health Organization, 2012.

Guillen U, Weiss EM, Munson D, Maton P, Jefferies A, Norman M, Naulaers G, Mendes J, Justo da Silva L, Zoban P, Hansen TW, Hallman M, Delivoria-Papadopoulos M, Hosono S, Albersheim SG, Williams C, Boyle E, Lui K, Darlow B, Kirpalani H. Guidelines for the Management of Extremely Premature Deliveries: A Systematic Review. Pediatrics. 2015;136(2):343-50.

Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388(10063):3027-35. doi: 10.1016/S0140-6736(16)31593-8.

Peña-Bautista C, Durand T, Vigor C, Oger C, Galano JM, Cháfer-Pericás C. Non-invasive assessment of oxidative stress in preterm infants. Free Radic Biol Med. 2019;142:73-81. doi: 10.1016/j.freeradbiomed.2019.02.019

Ozsurekci Y, Aykac K. Oxidative Stress Related Diseases in Newborns. Oxid Med Cell Longev. 2016;2016:2768365. PMid:27403229 PMCid:PMC4926016.

Marseglia L, D'Angelo G, Manti S, et al. Oxidative stress-mediated gained during the fetal and perinatal periods. Oxid Med Cell Longev. 2014;2014:358–375. PMid:25202436 PMCid:PMC4151547.

Chessex P, Watson C, Kaczala GW, et al. Determinants of oxidant stress in extremely low birth weight premature infants. Free Radic Biol Med. 2010;49:1380–6. doi: 10.1016/j.freeradbiomed.2010.07.018.

Platt MJ. Outcomes in preterm infants. Public Health. 2014;128(5):399-403. doi: 10.1016/j.puhe.2014.03.010.

Mutinati M, Pantaleo M, Roncetti M, Piccinno M, Rizzo A, Sciorsci RL. Oxidative stress in neonatology: a review, Reprod Domest Anim. 2014;49(1):7–16. PMid:24112309.

Perron S, Tataranno ML, Negro S, et al. Early identification of the risk for free radical-related diseases in preterm newborns. Early Human Development.2010;86(4):241-244. PMid:20466493.

Bahbah M, Deeb M, Ragab S, El-Shafie M. Study of oxidative stress in common neonatal disorders and evaluation of antioxidant strategies. Menoufia Medical Journal. 2015;28:348–354.

Vento M, Aguar M, Escobar J, Arduini A, Escrig R, Brugada M, et al. Antenatal steroids and antioxidant enzyme activity in preterm infants: influence of gender and timing. Antioxid Redox Signal. 2009;11:2945-2955. PMid:19645572.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism