Effects of liposomal form of phosphatidylcholine on oxidative-nitrosative stress in renal tissues of rats in burn disease

Ya. O. Basarab, L. H. Netyukhailo

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.10.017

Abstract


This experiment carried out on 77 white Wistar rats aimed at studying the effects of liposomal form of phosphatidylcholine (lipin) on oxidative-nitrosative stress in renal tissues in burn disease (BD). This condition was modelled by immersing the epilated skin surface of the hind limb of the experimental animals into hot water (t + 70 –75°C) under light ether anaesthesia for 7 s that led to the development of III A-B degree burns. Lipin was administered intraperitoneally daily in a dose of 50 mg / kg immediately after BD modelling.

The research has demonstrated BD modelling is accompanied by the development of oxidative-nitrosative stress in renal tissues as evidenced by a significant increase in the superoxide anion radical production by various sources (endoplasmic reticulum and NO synthase, mitochondrial respiratory chain, leukocyte NADPH oxidase); by the growth in the activity of inducible isozyme of NO-synthase (in the stage of burn shock in 2.83 times, р<0.001) with a decline in the constitutive isoforms activity, by the rise in the concentration of peroxynitrite (in the stage of burn shock in 3.18 times, in the stage of septicotoxemia in 2.56 times).

The administration of lipin significantly limits the development of oxidative-nitrosative stress in renal tissues in the dynamics of experimental BD, as evidenced by a probable decrease in superoxide anion radical, NO-synthase activity due to its inducible isoform (in the stage of burn shock – by 35.9%; in the stage of toxemia – by 43.1%, p<0.001), by redressing the imbalance between inducible and constitutive isozymes of NO-synthase, by reducing the concentration of peroxynitrite (in the stage of burn shock – by 34.3%, in the stage of late toxemia – by 44.3%; in the stage of septicotoxemia – by 44.3%, p<0.001).


Keywords


burn disease; oxidative-nitrosative stress; free radical processes; kidney; liposomal form of phosphatidylcholine (lipin)

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References


World Health Organization. Burns. Available from: https://www.who.int/en/news-room/fact-sheets/detail/burns (WHO, 2018).

National Center for Injury Prevention and Control. United States fire/burn deaths and rates per 100,000. Office of Statistics and Programming, Centers for Disease Control and Prevention, Atlanta, Ga; 2002.

Feng JY, Chien JY, Kao KC et al. Predictors of Early Onset Multiple Organ Dysfunction in Major Burn Patients with Ventilator Support: Experience from A Mass Casualty Explosion. Sci Rep. 2018;8(1):10939.

Jeschke MG, Pinto R, Kraft R et al. Morbidity and survival probability in burn patients in modern burn care. Crit Care Med. 2015;43:808–15.

Lin CY, Chen YC. Acute kidney injury classification: AKIN and RIFLE criteria in critical patients. World J Crit Care Med. 2012;1(2):40-5.

Clark A, Neyra JA, Madni T et al. Acute kidney injury after burn. Burns. 2017;43(5):898-908.

Clark AT, Li X, Kulangara R, Adams-Huet B et al. Acute Kidney Injury After Burn: A Cohort Study From the Parkland Burn Intensive Care Unit. J Burn Care Res. 2019 Jan 1;40(1):72-8.

Burmeister DM, Gómez BI, Dubick MA. Molecular mechanisms of trauma-induced acute kidney injury: Inflammatory and metabolic insights from animal models. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2661-71.

Saitoh D, Kadota T, Senoh A et al. Superoxide dismutase with prolonged in vivo half-life inhibits intravascular hemolysis and renal injury in burned rats. Am J Emerg Med. 1993 Jul;11(4):355-9.

Dobrelya NV, Khromov OS, Bukhtiarova TA. Lipin za hipoksychnykh staniv: vid eksperymentu do kliniky [Lipin in hypoxic conditions: from experiment to clinic]. Farmakolohiya ta likarsʹka toksykolohiya. 2020;14(3):166–76. (in Ukrainian)

Klymenko MO, Netyukhaylo LH. Strukturno-metabolichni zminy lehenʹ ta yikh korektsiya pry opikoviy khvorobi [Structural and metabolic changes of the lungs and their correction in burn disease]. GlobeEdit; 2020. 124 s. (in Ukrainian)

Kostenko VO, Tsebrzhins'kii OI. Produktsiya superoksydnoho anion-radykala ta oksydu azotu u tkanyni nyrok pislya khirurhichnoho vtruchannya [Production of superoxide anion radical and nitric oxide in renal tissues sutured with different surgical suture material]. Fiziol Zh. 2000; 46(5):56-62. (in Ukrainian)

Akimov OYe, Kostenko VO. Functioning of nitric oxide cycle in gastric mucosa of rats under excessive combined intake of sodium nitrate and fluoride. Ukr Biochem J. 2016;88(6):70-5.

Yelins’ka AM, Akimov OYe, Kostenko VO. Role of AP-1 transcriptional factor in development of oxidative and nitrosative stress in periodontal tissues during systemic inflammatory response. Ukr Biochem J. 2019;91(1):80-5.

Ahmad A, Dempsey SK, Daneva Z et al. Role of Nitric Oxide in the Cardiovascular and Renal Systems. Int J Mol Sci. 2018 Sep 3;19(9):2605.

Hsu CN, Tain YL. Regulation of Nitric Oxide Production in the Developmental Programming of Hypertension and Kidney Disease. Int J Mol Sci. 2019 Feb 5;20(3):681.

Tsay TB, Yang MC, Chen PH et al. TNF-alpha decreases infection-induced lung injury in burn through negative regulation of TLR4/iNOS. J Surg Res. 2013 Jan;179(1):106-14.

Goligorsky MS, Brodsky SV, Noiri E. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int. 2002 Mar;61(3):855-61.

Seija M, Baccino C, Nin N et al. Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats. Shock. 2012 Oct;38(4):403-10.


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