Pathomorphological changes in the structure of intervertebral disc after seven and fourteen days of experimental opioid use

M. V. Pankiv, Y. V. Paltov



We aimed to study the pathomorphological changes in the structure of intervertebral disc in the early stages of the experimental opioid use. This goal was achieved by the use of histological visualization of the intervertebral disc’s structures. Histological specimens were prepared according to the typical methods using such  specimens as hematoxylin, eosin, azan and due to Heidenhain method, McManus PAS-reaction and Steedman alcian blue method.

The results of this study will let form a pathomorphological basis that could be used for comparative characterization of the growth dynamics of pathomorphological changes in the intervertebral disc’s structures in the early stages and compare these changes to pathomorphological signs in the late stages of experimental opioid use. These findings will provide an opportunity to establish the most appropriate time limits when these pathomorphological changes in the structure of the intervertebral disc develop and to observe the dynamics of these changes in the long term experimental opioid use.


opioid, intervertebral disc; rat; early terms

Full Text:



Biriuchkov MIu. The specific features of surgery of herniated intervertebral disks. Zh Vopr Neirokhir Im N N Burdenko. 2005 Oct-Dec; 4:22- 4.

Pinchuk SV. Modeling the lumbar spine computer tomography sizes on median-sagittal sections using regression analysis in healthy young men depending on anthropo-somatotypological indicators. Pinchuk SV, Volkov KS, Kryvko YuYa., Shayuk AV. Aktualni pytannya medychnoi nauky ta praktyky. 2015; 82. Р. 136-42.

Pinchuk SV, Shayuk AV. А clinical value and problems of determination of morphometric parameters of lumbar spine in a norm and at pathology. Review of literature. Ukrainskyi medychnyi almanakh. 2013;16.5. Р.101-106.

Gubin AV. The etiology of acute torticollis in children. In: Proceedings of the scientific-practical conference with international participation. Gubin AV, Ulrich EV, Yalfimov AN, Taschilkin AI. Actual problems of children's traumatology and orthope- dics; 2008; Kazan, Russia. Kazan; 2008. Р.170-171.

Dudin MG. On etiopathogenesis of idiopathic scoliosis. Dudin MG, Pinchuk DYu, Bekshaev SS, et.all. Spine Surgery. 2006;(4):18-25.

Dmitriev AE, Tenants VK, Vavilov SB. Computed tomography in the diagnosis of degener- ative lesions of the spine - intervertebral disc herniation. Clinical Medicine. 2009. 4. P. 93-95.

Kostyuk GY, Vlasyuk VL Magnetic resonance imaging in the diagnosis and treatment of herniated discs. Clinical anatomy and operative surgery. 2008;7. 3. P. 53-56.

Hosten N. Computed tomography of the head and spine. 2nd ed. Hosten N, Liebig T. MED press-inform; 2013. 576 p.

Onysko RM, Paltov EV, Fik VB, Vilkhova IV, Kryvko Yu.Ya. ., Yakymiv N.Ya., Fitkalo OS. Pat. №76564 U Ukraine, IPC A 61 K 31/00 Method of modeling physical opioid dependence in rats. Рatent owner: Danylo Halytskyi Lviv National Medical University. 201u201207124; declared 12.06.2012; publ. 10.01.2013, Bull. №1.

Romeis B. Microscopic technique. M. Medicine. 1953: 71 - 72.

Goralsky LP, Khomich VT, Kononsky OI Edited by Goralsky LP Fundamentals of histological technique and morphofunctional research methods in normal and pathology. Tutorial. Kind. III, corrected and supplemented. Zhytomyr: Polissya.2015:286.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism