Clinically pathogenic aspects of the comprehensive treatment of burn scars

Abstract

Any deformities of general anatomical organization of the tissue at gradual deprivation of function can be relegated to the wounds which are relative to the pain syndrome and functional abnormality of the affected area of the body and cosmetic defects except for psycho-emotional disorders and they are also economic burdens for patients, their families and society. Thus short-term wound healing of high quality has high clinical value as it may lead to reduction in hospitalization and coming-back to the performance capability of patients [1]. Dermal wound healing is a dynamic and highly adjustable process of cellular, humoral and molecular mechanisms which starts after the injury and it may last for years. The correlation of cells, growth promoting substances and cytokines ends with wound healing even if a sensitive balance between cells and mediators may be imperfect, the results of the investigative procedure shows that deficit of cellular factor or mediator can be compensated with other components which take part in wound healing, thus the reactivation may still take place. An inflammatory reaction is certain under the physiologic wound healing: cell lines, functions and mediators [2]. The understanding of the sequence and chronology of processes of the wound healing, particularly the evolution of growth promoting substance and cytokine effects which leads to cell and tissue changes which are necessary for reparative processes, (Simpson and Ross, 1972; Leibovich and Ross, 1975) physiologic spatiotemporal changeability of sequential leucocyte form is shown by experiments (Martin 1997; Singer and Clark, 1999) and also the effect of competently selected corrective measures lets us achieve maximum impact of medical treatment.

Suggested compound method of correction of burn scars which combines cryosurgical method with xenotransplantation, injections of steroids in scars, laser genesis procedures and compression clothes with silicone plates guarantees high efficiency of treatment of burn scars.