Neonatal intestinal microbiota factors

Agata Mularczyk, Anna Stangret, Angelika Szczęśniak, Katarzyna Topczewska, Karolina Rogulska



Intestinal microbiota is a key element in maintaining health. Recently, the relationship between the microbiome and specific disease entities has been emphasized. A relationship between the composition of commensal flora and obesity, allergies, cancer and autism is suggested. Studies are available on factors that affect the formation of bacterial microflora in newborns. The pregnant microflora may affect the unborn baby. The study found the presence of bacteria in amniotic fluid, umbilical cord blood, placenta and fetal membranes. The microbiome of newborns born by caesarean section remove the one found on the mother's skin and function and in the operating room while the newborn born by nature pathways is close to the microflora of the mother's vagina. There was also a difference in the microbiome of newborns born in the hospital and at home. Breastfeeding also affects the intestinal microflora. Mother's milk and infant faeces show the same bacterial strains.

Intestinal dysbiosis may be the basis for a number of disease entities. It is necessary to know the prenatal and postnatal properties influencing the gastrointestinal colonization of the newborn. This knowledge will help develop guidelines favorable for normal colonization with microorganism of the neonatal intestines.


microbiom, labor, pregnant, breastfeeding

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Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. Review The Central Nervous System and the Gut Microbiome. Cell. 2016;167(4):915–32.

Cho I, Blaser MJ. The human microbiome : at the interface of health and disease. 2012;13(April).

Antony KM, Versalovic J. The Placenta Harbors a Unique Microbiome The Placenta Harbors a Unique Microbiome. 2014;(May).

Hu J, Nomura Y, Bashir A, Fernandez-hernandez H, Itzkowitz S, Pei Z, et al. Diversified Microbiota of Meconium Is Affected by Maternal Diabetes Status. 2013;8(11).

Jeurink P V., van Bergenhenegouwen J, Jiménez E, Knippels LMJ, Fernández L, Garssen J, et al. Human milk: A source of more life than we imagine. Benef Microbes. 2013;4(1):17–30.

Chu DM, Antony KM, Ma J, Prince AL, Showalter L, Moller M. The early infant gut microbiome varies in association with a maternal high-fat diet. Genome Med. 2016;1–12.

Zijlmans MAC, Korpela K, Riksen-walraven JM, Vos WM De, Weerth C De. Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology. 2015;53:233–45.

Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;

Nahum GG. A 1120. 2006;107(5).

Westerbeek EAM, Berg A Van Den, Lafeber HN, Knol J, Fetter WPF, Elburg RM Van. The intestinal bacterial colonisation in preterm infants : A review of the literature. 2006;361–8.

Combellick JL, Shin H, Shin D, Cai Y, Hagan H, Lacher C, et al. Differences in the fecal microbiota of neonates born at home or in the hospital. Sci Rep. 2018;1–9.

Dominguez Bello MG. Effects of C-section on the human microbiota. Vol. 31, American Journal of Human Biology. Wiley-Liss Inc.; 2019.

Martinez KA, Devlin JC, Lacher CR, Yin Y, Cai Y, Wang J, et al. Increased weight gain by C-section: Functional significance of the primordial microbiome. Sci Adv. 2017 Oct 1;3(10).

Polidano C, Zhu A, Bornstein JC. The relation between cesarean birth and child cognitive development. Sci Rep. 2017;7(1):1–10.

Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008;38(4):629–33.

Goedert JJ, Hua X, Yu G, Shi J. EBioMedicine Diversity and Composition of the Adult Fecal Microbiome Associated with History of Cesarean Birth or Appendectomy : Analysis of the American Gut Project. EBIOM. 2014;1(2–3):167–72.

Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-datchary P. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life Resource Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. 2015;690–703.

Shin H, Pei Z, Martinez KA, Rivera-Vinas JI, Mendez K, Cavallin H, et al. The first microbial environment of infants born by C-section: the operating room microbes. Microbiome. 2015;3(2015):59.

Dominguez-bello MG, Dominguez-bello MG, Jesus-laboy KM De, Rivera-vinas JI, Mendez K, Knight R. Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Nat Med. 2016;(February 2018):1–5.

Haahr T, Glavind J, Axelsson P, Bistrup Fischer M, Bjurström J, Andrésdóttir G, et al. Vaginal seeding or vaginal microbial transfer from the mother to the caesarean-born neonate: a commentary regarding clinical management. BJOG An Int J Obstet Gynaecol. 2018;125(5):533–6.

Praveen P, Jordan F, Priami C, Morine MJ. The role of breast-feeding in infant immune system : a systems perspective on the intestinal microbiome. Microbiome. 2015;1–12.

Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019 Jun 1;68(6):1108–14.

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