Assessment of severity of cystic fibrosis in children depending on the vitamin D status

Veronika Dudnyk, Valeriia Demianyshyna

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.09.068

Abstract


Introduction.

Severity of CF depends on speed of lung disease progression which depend on many factors. Patients with CF suffer from vitamin D deficiency that could contribute to decreasing of lung function due to anti-inflammatory and antimicrobial activity. Correction of vitamin D3 level may be a potentially effective way to keep pulmonary function in such patients.

Purpose. Evaluation of severity of CF in children depending on the vitamin D3 level in blood serum.

Materials and methods. 84 children suffering from CF have been examined. Level of 25 (ОН) D3 in blood serum measured with immunosorbent assay. Patients were performed spirometry and the bacteriograms of sputum coughed up by children were analyzed.

Results.  Measurement of serum vitamin D3 among children with cystic fibrosis showed that 58,3% of subjects had insufficiency. Children who suffered from severe CF had significant lower serum 25 (OH) D3 concentrations. It was shown that children with insufficient level of 25 (OH) D3 had higher risk of FEV1 rate decreasing less than 64 %, and significant association with Ps. aeruginosa-positive culture was detected. Subjects with sufficient 25 (OH) D3 had strong association with higher rates of FEV1 and risk of Ps. aeruginosa-positive culture was also decreased.

ConclusionsVitamin D insufficiency is common among children with cystic fibrosis. It was found that there is a relationship between the content of 25 (OH) D3 and the severity of the disease. Children with low levels of 25 (OH) D3 are associated with lower FEV1 rates and have a higher risk of positive culture of Ps. aeruginosa.

 


Keywords


cystic fibrosis; children; vitamin D; severity of the disease.

Full Text:

PDF

References


Chung C., Silwal P., Kim I., Modlin R.L., Jo E. (2020) Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection. Immune Netw. 20(2). doi: 10.4110/in.2020.20.e12

Farrell, P. M., White, T. B., Ren, C. L., Hempstead, S. E., Accurso, F., Derichs, N., ... & Sermet-Gaudelus, I. (2017). Diagnosis of cystic fibrosis: consensus guidelines from the Cystic Fibrosis Foundation. The Journal of pediatrics, 181, S4-S15. https://doi.org/10.1016/j.jpeds.2016.09.064

Harun, S. N., Wainwright, C., Klein, K., & Hennig, S. (2016). A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis. Paediatric respiratory reviews, 20, 55-66. https://doi.org/10.1016/j.prrv.2016.03.002

Konstantinopoulou, S., & Tapia, I. E. (2017). Vitamin D and the lung. Paediatric Respiratory Reviews, 24, 39–43. doi:10.1016/j.prrv.2016.10.009

Simoneau, T., Bazzaz, O., Sawicki, G. S., & Gordon, C. (2014). Vitamin D status in children with cystic fibrosis. Associations with inflammation and bacterial colonization. Annals of the American Thoracic Society, 11(2), 205-210. DOI: 10.1513/AnnalsATS.201306-171BC


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism