Preeclampsia as a risk factor of the cardiovascular complications development

Alicja Maria Ozga, Aleksandra Obuchowska, Justyna Wójcik, Arkadiusz Standyło, Karolina Obuchowska, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak




The term “preeclampsia” (PE) refers to a multisystem disorder occurring after 20 weeks of pregnancy; it includes a new onset of hypertension and proteinuria and affects from 2 to 8% of all pregnancies. Cardiovascular disease (CVD) is a group of pathologies, which present significant mortality rate all over the world. The literature implicates that both disorders are linked in a sense of further cardiovascular complications in women who had preeclamptic pregnancy.


Evaluation of the relationship between pre-eclampsia and the risk of future potential maternal cardiovascular complications and proposal of the possible causes of this association.

Materials and methods:

We performed the database research using Pubmed, Springer Link and ResearchGate and we made review and meta-analysis of relevant studies. We searched for studies analyzing the relationship between preeclampsia and future maternal cardiovascular risk.


Systematic reviews and cohort studies qualified for the purpose of this review showed the relationship between preeclampsia and future cardiovascular diseases in mothers. The possible explanations include endothelium dysfunction enduring after delivery and the co-existence of common risk factors for both diseases.


Preeclampsia is a risk factor predisposing to cardiovascular diseases and may lead to cardiac complications later in life. The course of pregnancies is very important for the future maternal health.

Key words: preeclampsia; pregnancy; hypertension; cardiovascular disease


preeclampsia; pregnancy; hypertension; cardiovascular disease

Full Text:



Scantlebury, Dawn & Hayes, Sharonne. (2014). How Does Preeclampsia Predispose to Future Cardiovascular Disease?. Current hypertension reports. 16. 472. 10.1007/s11906-014-0472-6.

Lin YS, Tang CH, Yang CY, Wu LS, Hung ST, Hwa HL, et al. Effect of pre-eclampsia-eclampsia on major cardiovascular events among peripartum women in Taiwan. Am J Cardiol. 2011;107(2):325–30. doi:10.1016/j.amjcard.2010.08.073.

Hannaford P, Ferry S, Hirsch S. Cardiovascular sequelae of toxaemia of pregnancy. Heart (British Cardiac Society). 1997 Feb;77(2):154-158. DOI: 10.1136/hrt.77.2.154.

Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335(7627):974. doi:10.1136/bmj.39335.385301.BE

ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2019;133(1):e1-e25. doi:10.1097/AOG.0000000000003018

Prejbisz A, Dobrowolski P, Kosiński P, et al. Management of hypertension in pregnancy: prevention, diagnosis, treatment and long‐term prognosis. A position statement of the Polish Society of Hypertension, Polish Cardiac Society and Polish Society of Gynecologists and Obstetricians. Kardiol Pol. 2019; 77:757-806. doi:10.33963/KP.14904

Poirier, Paul & Després, Jean-Pierre. (2003). Obesity and Cardiovascular Disease. Médecine sciences : M/S. 19. 943-9. 10.1051/medsci/20031910943.

Goode GK, Miller JP, Heagerty HM. Hyperlipidaemia, hypertension and coronary heart disease. Lancet 1995;345:362-4.

Kannel WB, Neaton JD, Wentworth D, Thomas HE, Stamler J, Hulley SB, Kjelsberg MO. Overall and coronary heart disease mortality rates in relation to major risk factors in 325,348 men screened for the MRFIT: Multiple Risk Factor Intervention Trial. Am Heart J.1986; 112:825-836.

Ray JG, Schull MJ, Kingdom JC, Vermeulen MJ. Heart failure and dysrhythmias after maternal placental syndromes: HAD MPS Study. Heart. 2012;98(15):1136–41. doi:10.1136/heartjnl-2011-301548.

Gaillard R, Steegers EA, Hofman A, Jaddoe VW. Associations of maternal obesity with blood pressure and the risks of gestational hypertensive disorders. The Generation R Study. J Hypertens. 2011;29(5):937-944. doi:10.1097/HJH.0b013e328345500c

Ray JG, Vermeulen MJ, Schull MJ, McDonald S, Redelmeier DA. Metabolic syndrome and the risk of placental dysfunction. J Obstet Gynaecol Can. 2005;27(12):1095–101.

Mannisto T, Mendola P, Vaarasmaki M, Jarvelin MR, Hartikainen AL, Pouta A, et al. Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation. 2013;127(6):681–90. doi:10.1161/CIRCULATIONAHA.112.128751.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism