Case of Adult-Onset Still’s Disease in 65-year-old man

Konrad Warchoł, Sylwiusz Niedobylski, Katarzyna Laszczak, Kamila Giżewska, Paweł Królik



Adult-onset Still's disease (AOSD) is an uncommon condition that presents itself as difficult to diagnose, due to non-specific symptoms and the necessity to exclude any underlying causes. We present a case of a 65-year-old man with slight fever, loss of weight, pain and stiffness of joints. After successful diagnosis, corticosteroids were administered, which resulted in rapid improvement in the condition of the patient.


Adult-onset Still's disease; fever; autoimmune disease; joint

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G. F. Still, ‘On a Form of Chronic Joint Disease in Children’, Medico-Chir. Trans., vol. 80, pp. 47-60.9, 1897.

E. G. Bywaters, ‘Still’s disease in the adult.’, Ann. Rheum. Dis., vol. 30, no. 2, pp. 121–133, Mar. 1971, doi: 10.1136/ard.30.2.121.

T. Mimura et al., ‘Evidence-based clinical practice guideline for adult Still’s disease’, Mod. Rheumatol., vol. 28, no. 5, pp. 736–757, Sep. 2018, doi: 10.1080/14397595.2018.1465633.

S. Castañeda, R. Blanco, and M. A. González-Gay, ‘Adult-onset Still’s disease: Advances in the treatment’, Best Pract. Res. Clin. Rheumatol., vol. 30, no. 2, pp. 222–238, Apr. 2016, doi: 10.1016/j.berh.2016.08.003.

K. J. Evensen and H. C. Nossent, ‘Epidemiology and outcome of adult‐onset Still’s disease in Northern Norway’, Scand. J. Rheumatol., vol. 35, no. 1, pp. 48–51, Jan. 2006, doi: 10.1080/03009740510026616.

Y. F. Asanuma et al., ‘Nationwide epidemiological survey of 169 patients with adult Still’s disease in Japan’, Mod. Rheumatol., vol. 25, no. 3, pp. 393–400, May 2015, doi: 10.3109/14397595.2014.974881.

G. Magadur-Joly et al., ‘Epidemiology of adult Still’s disease: estimate of the incidence by a retrospective study in west France.’, Ann. Rheum. Dis., vol. 54, no. 7, pp. 587–590, Jul. 1995, doi: 10.1136/ard.54.7.587.

E. Feist, S. Mitrovic, and B. Fautrel, ‘Mechanisms, biomarkers and targets for adult-onset Still’s disease’, Nat. Rev. Rheumatol., vol. 14, no. 10, Art. no. 10, Oct. 2018, doi: 10.1038/s41584-018-0081-x.

B. Wawrzycki, D. Krasowska, A. Pietrzak, E. Wielosz, M. Majdan, and T. Lotti, “Urticarial rash, fever, and arthritis: A case of refractory Adult‐onset Still’s disease with good response to tocilizumab,” Dermatologic Therapy, vol. 32, no. 5, Aug. 2019.

Y. Cagatay et al., “Adult-onset still’s disease,” International Journal of Clinical Practice, vol. 63, no. 7, pp. 1050–1055, Jul. 2009.

A. Cozzi, A. Papagrigoraki, D. Biasi, C. Colato, and G. Girolomoni, “Cutaneous manifestations of adult-onset Still’s disease: a case report and review of literature,” Clinical Rheumatology, vol. 35, no. 5, pp. 1377–1382, Apr. 2014.

Pouchot J;Sampalis JS;Beaudet F;Carette S;Décary F;Salusinsky-Sternbach M;Hill RO;Gutkowski A;Harth M;Myhal D, “Adult Still’s disease: manifestations, disease course, and outcome in 62 patients,” Medicine, vol. 70, no. 2, 2020.

R. Giacomelli, P. Ruscitti, and Y. Shoenfeld, “A comprehensive review on adult onset Still’s disease,” Journal of Autoimmunity, vol. 93, pp. 24–36, Sep. 2018.

Golbarg Mehrpoor, Mohammad Bagher Owlia, Hossein Soleimani, and Jamshid Ayatollahi, “Adult-onset Still’s disease: a report of 28 cases and review of the literature,” Modern Rheumatology, vol. 18, no. 5, pp. 480–485, Aug. 2008.

J. M. Wouters, J. van der Veen, L. B. van de Putte, and D. J. de Rooij, “Adult onset Still’s disease and viral infections.,” Annals of the Rheumatic Diseases, vol. 47, no. 9, pp. 764–767, Sep. 1988.

R. Terkeltaub, J. M. Esdaile, F. Décary, M. Harth, J. Lister, and N. Lapointe, “HLA—Bw35 and Prognosis in Adult Still’s Disease,” Arthritis & Rheumatism, vol. 24, no. 12, pp. 1469–1472, Dec. 1981.

T. Sugiura et al., “Association between adult-onset Still’s disease and interleukin-18 gene polymorphisms,” Genes & Immunity, vol. 3, no. 7, pp. 394–399, Nov. 2002.

F.-F. Wang et al., “A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still’s disease,” Arthritis Research & Therapy, vol. 15, no. 3, p. R65, 2013.

M. Yashiro et al., “Serum amyloid A1 (SAA1) gene polymorphisms in Japanese patients with adult-onset Still’s disease,” Medicine, vol. 97, no. 49, p. e13394, Dec. 2018.

M.-Y. Wang, J.-C. Jia, C.-D. Yang, and Q.-Y. Hu, “Pathogenesis, disease course, and prognosis of adult-onset Stillʼs disease,” Chinese Medical Journal, vol. 132, no. 23, pp. 2856–2864, Dec. 2019.

S. Mitrovic and B. Fautrel, “New Markers for Adult-Onset Still’s Disease,” Joint Bone Spine, vol. 85, no. 3, pp. 285–293, May 2018.

S. Colafrancesco, R. Priori, and G. Valesini, “Presentation and diagnosis of adult-onset Still’s disease: The implications of current and emerging markers in overcoming the diagnostic challenge,” Expert Review of Clinical Immunology, vol. 11, no. 6. Expert Reviews Ltd., pp. 749–761, Jun. 01, 2015, doi: 10.1586/1744666X.2015.1037287.

E. Feist, S. Mitrovic, and B. Fautrel, “Mechanisms, biomarkers and targets for adult-onset Still’s disease,” Nature Reviews Rheumatology, vol. 14, no. 10, pp. 603–618, Sep. 2018.

B. Fautrel, “Adult-onset Still disease,” Best Practice & Research Clinical Rheumatology, vol. 22, no. 5, pp. 773–792, Oct. 2008.

P. Sève, Y. Jamilloux, M. Gerfaud-Valentin, and T. Henry, “Treatment of adult-onset Still's disease: a review,” Ther. Clin. Risk Manag., vol. 11, p. 33, Dec. 2014, doi: 10.2147/TCRM.S64951.

E. Feist, S. Mitrovic, and B. Fautrel, “Mechanisms, biomarkers and targets for adult-onset Still’s disease,” Nature Reviews Rheumatology, vol. 14, no. 10. Nature Publishing Group, pp. 603–618, Oct. 01, 2018, doi: 10.1038/s41584-018-0081-x.

Cheema, Gurtej S. MD; Quismorio, Francisco P. Jr. MD Pulmonary involvement in adult-onset Still’s disease, Current Opinion in Pulmonary Medicine: September 1999 - Volume 5 - Issue 5 - p 305-309

P. Efthimiou, S. Kadavath, and B. Mehta, “Life-threatening complications of adult-onset Still’s disease,” Clinical Rheumatology, vol. 33, no. 3. Springer-Verlag London Ltd, pp. 305–314, Jan. 17, 2014, doi: 10.1007/s10067-014-2487-4.

P. Sfriso, S. Bindoli, and P. Galozzi, “Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances,” Drugs, vol. 78, no. 12, pp. 1187–1195, Aug. 2018, doi: 10.1007/s40265-018-0956-9.

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