The state of mineralizing properties of the saliva in children with gastroesophageal reflux disease

S. A. Schneider, A. Yu. Saleh, O. V. Denga



Gastroesophageal reflux disease (GERD) is one of the most common, potentially dangerous gastrointestinal diseases, which, according to the World Health Organization (WHO), is considered to be a disease of the 21st century. In addition, there is a "rejuvenation" of this nosological form. The frequency of pathology of the digestive system among the pediatric population ofUkraine is the second only to the diseases of the respiratory system. The oral cavity is the beginning of the digestive tract, and its mucous membrane is an important integral component of the system of anatomical and physiological connections of the gastrointestinal tract, and the oral fluid is one of the most important elements that perform the mineralizing function.

The authors conducted the investigation to study the mineralizing properties of the saliva in children with GERD, which involved 92 children, of whom 45 children had manifestations of GERD; the remaining 47 were somatically healthy. The content of ionized calcium and inorganic phosphates together, ∆pH, as well as the state of bone metabolism were studied in order to detect a disturbance of the total mineralization of the bone tissue using an ultrasonic densitometer.

A decrease in the mineralizing properties of the mixed saliva was found in patients with GERD.


gastroesophageal reflux disease; children

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Privorotsky V.F. Gastroesophageal reflux disease (GERD) in children / V.F. Privorotsky, N.E.Luppova, Т.А. Gerasimova et al. // Experimental and clinical gastroenterology. - 2011. - N01. - P.14 - 21.

Zubarenko O.V. Modern view of gastroesophageal reflux disease in children / O.V. Zubarenko, T.Yu. Kravchenko // Perinatology and pediatrics. - 2013. - N1 (53). - P.114 - 122.

Belmer S.W. Gastroesophageal reflux disease in children: domestic working protocol of 2013 / S.V. Belmer, W.F. Privorotsky // The attending physician. - 2013. - N8. - P. 66 - 71.

Basalaeva N.V. Features of the formation of gastroesophageal reflux disease in children / N.V. Basalaeva, Yu.S.Apenchenko, A.F. Vinogradov, etc. // Bulletin of new medical technologies. - 2012. - Vol. XIX. - N2. - P. 145 - 148.

Zakirov I.I. Respiratory manifestations of gastroesophageal reflux in children / I.I. Zakirov, A.I. Safina // Bulletin of modern clinical medicine. - 2016. - Volume 9. - issue. 2. - P. 46 - 52.

Maev I.V. Dental manifestations of gastroesophageal reflux disease / I.V. Maev, G.M.Barer, G.A. Busarova et al. // Clinical medicine. - 2005. - N11. - P. 33 - 38.

Keshav S. Visual gastroenterology: Teaching aid/ Translation from English C.V. Demicheva; under ed. V.T. Ivashkina // M .: GEOTAR, Media. - 2005. - P. 15.

Barron R. P. Dental erosion in gastroesophageal reflux disease / R. P. Barron, R. P. Carmichael, M. A. Marcon et al // Journal (Canadian Dental Association). - 2003. - Vol.69. - Iss. 2. - P. 84 - 89.

Mirsalikhova F.L. Influence of mineralizing potential of the oral fluid on the level of caries resistance of tooth enamel / F.L. Mirsalikhova, G.I. Abdirimova, G.M. Akhmedova // Proceedings of the 3rd All-Russian scientific-practical conference with international participation "Topical issues of prevention of dental diseases". - 2017 -P. 125 - 126.

Leontiev V.K. Children's therapeutic dentistry / V.K. Leontiev, L.P. Kiselnikova // M: - 2010. - 415 p.

Beloklitskaya G.F. Evaluation of the effectiveness of a comprehensive approach to the treatment of hard tissue hyperesthesia of the teeth of different etiology associated with gastroesophageal reflux disease, based on changes in acid-base homeostasis of oral fluid / G..F Beloklitskaya, N.V. Savchenko V.A. Pakhomov // Modern dentistry. - 2014. - N 1 (70). - P. 54.

Levitsky A.P. Salivation in healthy people of different ages and in dental patients / A.P. Levitsky, O.A. Makarenko, L.N. Rossakhanova // Bulletin of dentistry. - 2005. - N 2 (special issue). - P. 7 - 8.

Goryachkovsky A.M. Clinical biochemistry in laboratory diagnostics: [reference manual] ed. 3rd updated/ A.M. Goryachkovsky // Odessa: Ecology. - 2005. - 616 c.

Povoroznyuk V.V. Bone system and periodontal diseases / V.V. Povoroznyuk, I.P. Mazur // K. - 2003. - 446 p.

Ostrovsky O.V. Biochemistry of the oral cavity: Textbook (edited by Prof. O.V. Ostrovsky) / O.V. Ostrovsky Островский, V.A.Khramov, T.A. Popova // Volgograd: Izd-vo VolGMU, - 2010. - 184 p.

Drogomyretska M.S. Pathogenetic principles of orthodontic treatment of dental anomalies in adults with periodontitis against the background of atherosclerosis and hypoestrogenism: dis. for doctor of medical sciences/ М.С. Drohomyretska // Odessa. - 2010. - 334 p.

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