Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Gut microbiota and its impact on neuropsychiatric disorders
  • Home
  • /
  • Gut microbiota and its impact on neuropsychiatric disorders
  1. Home /
  2. Archives /
  3. Vol. 10 No. 8 (2020) /
  4. Review Articles

Gut microbiota and its impact on neuropsychiatric disorders

Authors

  • Magdalena Wójcik Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin https://orcid.org/0000-0002-0999-6284
  • Justyna Dąbrowska Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin https://orcid.org/0000-0002-1356-6965
  • Damian Bator Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin https://orcid.org/0000-0002-8464-932X
  • Joanna Milanowska Department of Applied Psychology, Medical University of Lublin, Lublin https://orcid.org/0000-0001-9741-1583

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.032

Keywords

gut microbiota, dysbiosis, schizophrenia, bipolar disorder

Abstract

Introduction: Over the last few decades, the interest of microbiota- gut – brain axis has increased. It is thought to have an impact on the overall health of the host. Gut microbiota and central nervous system can communicate in different ways. The connection between them is especially interesting in case of neuropsychiatric diseases

The aim of the study: The purpose of this systemic review was to collect and analyse current data of the association between gut microbiota and neuropsychitric disorders, specifically schizophrenia and bipolar disorder

Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed and Google Scholar database was carried out using the following keywords: gut microbiota, dysbiosis, schizophrenia, bipolar disorder

Description of the state of knowledge: Dysregulation of microbiota is a potential factor in pathogenesis of brain disorders. Gut microbiome is thought to be an important part of not only normal brain development, but also modulation of host physiological systems. Studies show that the composition of microbiota in psychiatric diseases including schizophrenia and bipolar disorder differs from healthy individuals. Many environmental factors can change the composition of microbiota and therefore potentially contribute to the development of many disorders, including neuropsychiatric disorders.

Summary:  Microbiota is a potential factor contributing to the onset or modulating the course of many illnessis, including brain disorders The subject of imbalanced microbiota composition give hope for finding etiology or improving treatment of many disorders. However, it still requires more studies.

Author Biography

Joanna Milanowska, Department of Applied Psychology, Medical University of Lublin, Lublin

Dr n. med.

References

Wang HX, Wang YP. Gut Microbiota-brain Axis. Chin Med J (Engl). 2016;129(19):2373-2380. doi:10.4103/0366-6999.190667

Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biol. 2007;5(7):e177. doi:10.1371/journal.pbio.0050177

Rodiño-Janeiro BK, Vicario M, Alonso-Cotoner C, Pascua-García R, Santos J. A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies. Adv Ther. 2018;35(3):289-310. doi:10.1007/s12325-018-0673-5

Raskov H, Burcharth J, Pommergaard HC, Rosenberg J. Irritable bowel syndrome, the microbiota and the gut-brain axis. Gut Microbes. 2016;7(5):365-383. doi:10.1080/19490976.2016.1218585

Zhang M, Yang XJ. Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases. World J Gastroenterol. 2016;22(40):8905-8909. doi:10.3748/wjg.v22.i40.8905

Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186-194. doi:10.1016/j.bbi.2015.03.016

Huang TT, Lai JB, Du YL, Xu Y, Ruan LM, Hu SH. Current Understanding of Gut Microbiota in Mood Disorders: An Update of Human Studies. Front Genet. 2019;10:98. Published 2019 Feb 19. doi:10.3389/fgene.2019.00098

Li Q, Han Y, Dy ABC, Hagerman RJ. The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017;11:120. Published 2017 Apr 28. doi:10.3389/fncel.2017.00120

Borgo F, Riva A, Benetti A, Casiraghi MC, Bertelli S, et al. Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests. PLoS One. 2017;12(6):e0179739. Published 2017 Jun 21. doi:10.1371/journal.pone.0179739

Kleiman SC, Watson HJ, Bulik-Sullivan EC, Huh

EY, Tarantino LM et al. The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology. Psychosom Med. 2015;77(9):969-981.

doi:10.1097/PSY.0000000000000247

Mulak A, Bonaz B. Brain-gut-microbiota axis in Parkinson's disease. World J Gastroenterol. 2015;21(37):10609-10620. doi:10.3748/wjg.v21.i37.10609

Huo R, Zeng B, Zeng L, Cheng K, Li B et al. Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis. Front Cell Infect Microbiol. 2017;7:489. Published 2017 Nov 30. doi:10.3389/fcimb.2017.00489

Kim S, Jazwinski SM. The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology. 2018;64(6):513-520. doi:10.1159/000490615

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787-8803. doi:10.3748/wjg.v21.i29.8787

Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon Weickert C. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl Psychiatry. 2014;4(2):e365. Published 2014 Feb 25. doi:10.1038/tp.2014.8

Evans SJ, Bassis CM, Hein R, Assari S, Flowers SA, et al. The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res. 2017;87:23-29. doi:10.1016/j.jpsychires.2016.12.007

Castro-Nallar E, Bendall ML, Pérez-Losada M, Sabuncyan S, Severance EG et al. Composition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controls. PeerJ. 2015;3:e1140. Published 2015 Aug 25. doi:10.7717/peerj.1140

Tang WH, Kitai T, Hazen SL. Gut Microbiota in Cardiovascular Health and Disease. Circ Res. 2017;120(7):1183-1196. doi:10.1161/CIRCRESAHA.117.309715

Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Gut microbiota in autism and mood disorders. World J Gastroenterol. 2016;22(1):361-368. doi:10.3748/wjg.v22.i1.361

Belkaid Y, Harrison OJ. Homeostatic Immunity and the Microbiota. Immunity. 2017;46(4):562-576. doi:10.1016/j.immuni.2017.04.008

Gao J, Xu K, Liu H, Liu G, Bai M, et al. Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism. Front Cell Infect Microbiol. 2018;8:13. Published 2018 Feb 6. doi:10.3389/fcimb.2018.00013

Staley C, Weingarden AR, Khoruts A, Sadowsky MJ. Interaction of gut microbiota with bile acid metabolism and its influence on disease states. Appl Microbiol Biotechnol. 2017;101(1):47-64. doi:10.1007/s00253-016-8006-6

Boulangé CL, Neves AL, Chilloux J, Nicholson JK, Dumas ME. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016;8(1):42. Published 2016 Apr 20. doi:10.1186/s13073-016-0303-2

Vuong HE, Yano JM, Fung TC, Hsiao EY. The Microbiome and Host Behavior. Annu Rev Neurosci. 2017;40:21-49. doi:10.1146/annurev-neuro-072116-031347

Wang Y, Kasper LH. The role of microbiome in central nervous system disorders. Brain Behav Immun. 2014;38:1-12. doi:10.1016/j.bbi.2013.12.015

Zhu X, Han Y, Du J, Liu R, Jin K, Yi W. Microbiota-gut-brain axis and the central nervous system. Oncotarget. 2017;8(32):53829-53838. Published 2017 May 10. doi:10.18632/oncotarget.17754

Grenham S, Clarke G, Cryan JF, Dinan TG. Brain-gut-microbe communication in health and disease. Front Physiol. 2011;2:94. Published 2011 Dec 7. doi:10.3389/fphys.2011.00094

Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209.

Bonaz B, Sinniger V, Pellissier S. Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation. J Physiol. 2016;594(20):5781-5790. doi:10.1113/JP271539

Bravo JA, Forsythe P, Chew MV, Escaravage E,

Savignac HM, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050-16055. doi:10.1073/pnas.1102999108

Klarer M, Arnold M, Günther L, Winter C, Langhans W, Meyer U. Gut vagal afferents differentially modulate innate anxiety and learned fear. J Neurosci. 2014;34(21):7067-7076. doi:10.1523/JNEUROSCI.0252-14.2014

Poutahidis T, Kearney SM, Levkovich T, Qi P, Varian BJ, et al. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS One. 2013;8(10):e78898. Published 2013 Oct 30.

doi:10.1371/journal.pone.0078898

Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018;12:49. Published 2018 Feb 7.

doi:10.3389/fnins.2018.00049

Shi N, Li N, Duan X, Niu H. Interaction between the gut microbiome and mucosal immune system. Mil Med Res. 2017;4:14. Published 2017 Apr 27. doi:10.1186/s40779-017-0122-9

Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017;20(2):145-155. doi:10.1038/nn.4476

Rea K, Dinan TG, Cryan JF. The microbiome: A key regulator of stress and neuroinflammation. Neurobiol Stress. 2016;4:23-33. Published 2016 Mar 4. doi:10.1016/j.ynstr.2016.03.001

Sherwin E, Sandhu KV, Dinan TG, Cryan JF. May the Force Be With You: The Light and Dark Sides of the Microbiota-Gut-Brain Axis in Neuropsychiatry. CNS Drugs. 2016;30(11):1019-1041. doi:10.1007/s40263-016-0370-3

Sun M, Wu W, Liu Z, Cong Y. Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. J Gastroenterol. 2017;52(1):1-8. doi:10.1007/s00535-016-1242-9

Lin MY, de Zoete MR, van Putten JP, Strijbis K. Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases. Front Immunol. 2015;6:554. Published 2015 Nov 3. doi:10.3389/fimmu.2015.00554

Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016;7(3):189-200. doi:10.1080/19490976.2015.1134082

Ohira H, Tsutsui W, Fujioka Y. Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?. J Atheroscler Thromb. 2017;24(7):660-672. doi:10.5551/jat.RV17006

Lach G, Schellekens H, Dinan TG, Cryan JF. Anxiety, Depression, and the Microbiome: A Role for Gut Peptides. Neurotherapeutics. 2018;15(1):36-59. doi:10.1007/s13311-017-0585-0

Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC. Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. Clin Ther. 2015;37(5):984-995. doi:10.1016/j.clinthera.2015.04.002

Wong ML, Inserra A, Lewis MD, Mastronardi CA, Leong L et al. Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition. Mol Psychiatry. 2016;21(6):797-805. doi:10.1038/mp.2016.46

Diaz Heijtz R, Wang S, Anuar F, Qian Y, Björkholm B, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 2011;108(7):3047-3052. doi:10.1073/pnas.1010529108

Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, et al. Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med. 2016;8(343):343ra82. doi:10.1126/scitranslmed.aad7121

Kim YK, Shin C. The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments. Curr Neuropharmacol. 2018;16(5):559-573. doi:10.2174/1570159X15666170915141036

Manderino L, Carroll I, Azcarate-Peril MA, Rochette A, Heinberg L, et al. Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults. J Int Neuropsychol Soc. 2017;23(8):700-705. doi:10.1017/S1355617717000492

Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015;172(11):1075-1091. doi:10.1176/appi.ajp.2015.15020152

Galley JD, Bailey MT. Impact of stressor exposure on the interplay between commensal microbiota and host inflammation. Gut Microbes. 2014;5(3):390-396. doi:10.4161/gmic.28683

Huo R, Zeng B, Zeng L, Cheng K, Li B, et al. Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis. Front Cell Infect Microbiol. 2017;7:489. Published 2017 Nov 30. doi:10.3389/fcimb.2017.00489

Borrelli L, Aceto S, Agnisola C, De Paolo S, Dipineto L, et al. Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish. Sci Rep. 2016;6:30046. Published 2016 Jul 15. doi:10.1038/srep30046

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019;177(6):1600-1618.e17. doi:10.1016/j.cell.2019.05.004

den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325-2340. doi:10.1194/jlr.R036012

Lam YY, Maguire S, Palacios T, Caterson ID. Are the Gut Bacteria Telling Us to Eat or Not to Eat? Reviewing the Role of Gut Microbiota in the Etiology, Disease Progression and Treatment of Eating Disorders. Nutrients. 2017;9(6):602. Published 2017 Jun 14. doi:10.3390/nu9060602

Glenny EM, Bulik-Sullivan EC, Tang Q, Bulik CM, Carroll IM. Eating Disorders and the Intestinal Microbiota: Mechanisms of Energy Homeostasis and Behavioral Influence. Curr Psychiatry Rep. 2017;19(8):51. doi:10.1007/s11920-017-0797-3

Smyth AM, Lawrie SM. The neuroimmunology of schizophrenia. Clin Psychopharmacol Neurosci. 2013;11(3):107-117. doi:10.9758/cpn.2013.11.3.107

Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull. 2009;35(3):528-548. doi:10.1093/schbul/sbn187

Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci. 2009;32(9):485-495. doi:10.1016/j.tins.2009.05.007

Bonnín CDM, Reinares M, Martínez-Arán A, Jiménez E, Sánchez-Moreno J, et al. Improving Functioning, Quality of Life, and Well-being in Patients With Bipolar Disorder. Int J Neuropsychopharmacol.

;22(8):467-477. doi:10.1093/ijnp/pyz018

Harrison PJ, Geddes JR, Tunbridge EM. The Emerging Neurobiology of Bipolar Disorder. Trends Neurosci. 2018;41(1):18-30. doi:10.1016/j.tins.2017.10.006

Dickerson F, Severance E, Yolken R. The microbiome, immunity, and schizophrenia and bipolar disorder. Brain Behav Immun. 2017;62:46-52. doi:10.1016/j.bbi.2016.12.010

Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373(9659):234-239. doi:10.1016/S0140-6736(09)60072-6

Nguyen TT, Kosciolek T, Eyler LT, Knight R, Jeste DV. Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. J Psychiatr Res. 2018;99:50-61. doi:10.1016/j.jpsychires.2018.01.013

Zheng P, Zeng B, Liu M, Chen J, Pan J, et al. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice [published correction appears in Sci Adv. 2019 Jun 21;5(6):eaay2759]. Sci Adv. 2019;5(2):eaau8317. Published 2019 Feb 6. doi:10.1126/sciadv.aau8317

Liang W, Huang Y, Tan X, Wu J, Duan J, et al. Alterations Of Glycerophospholipid And Fatty Acyl Metabolism In Multiple Brain Regions Of Schizophrenia Microbiota Recipient Mice. Neuropsychiatr Dis Treat. 2019;15:3219-3229. Published 2019 Nov 19. doi:10.2147/NDT.S225982

Hu S, Li A, Huang T, Lai J, Li J, et al. Gut Microbiota Changes in Patients with Bipolar Depression. Adv Sci (Weinh). 2019;6(14):1900752. Published 2019 May 15. doi:10.1002/advs.201900752

Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, et al. Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls. Front Psychiatry. 2019;9:730. Published 2019 Jan 18. doi:10.3389/fpsyt.2018.00730

Downloads

  • PDF

Published

2020-08-20

How to Cite

1.
WÓJCIK, Magdalena, DĄBROWSKA, Justyna, BATOR, Damian and MILANOWSKA, Joanna. Gut microbiota and its impact on neuropsychiatric disorders. Journal of Education, Health and Sport. Online. 20 August 2020. Vol. 10, no. 8, pp. 276-285. [Accessed 1 July 2025]. DOI 10.12775/JEHS.2020.10.08.032.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 10 No. 8 (2020)

Section

Review Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 724
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

gut microbiota, dysbiosis, schizophrenia, bipolar disorder
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop