Endometriosis and ovarian cancer - what they have in common?

Natalia Zarankiewicz, Katarzyna Kosz, Aleksandra Kuchnicka, Martyna Zielińska, Natalia Wolanin, Bogumiła Ciseł

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.08.026


Introduction and purpose:

Endometriosis is one of the most common diseases among women in the reproductive age. Although its etiology remains not fully understood, several models of endometriosis development are taken into consideration. Many studies have been focused on hormonal and genetic alterations in endometriosis. The results of these studies allow for a thesis on common origin of endometriosis anda few types of ovarian cancer.

The aim of this review is to present actual knowledge about endometriosis’ development conditions and a possible association with ovarian cancer.

Material and method:

The review concerned articles published in years 2012-2020, which were collected in the PubMed and Google Scholar. Particular attention was paid to the development of both the endometriosis and Endometriosis-Related Ovarian Neoplasms (ERONs) and their genetic disorders.


Endometriosis development is connected with several risk factors and also immune, hormonal and genetic alterations. Some authors postulated that malignant transformation of endometriosis may be a multi-step process powered by increasing levels of estrogen. Many studies confirmed that mutations of ARID1A and PIK3CA genes are likely to be present in the majority of cases of ovarian cancer with adjacent endometriosis.


The awareness of clinical features and medical complications of endometriosis is spreading increasingly around the world. Many studies are focused on genetic causes of this illness. It may be supposed that we will be able to select women with endometriosis and increased risk of ovarian cancer and prevent its development.


endometriosis; ovarian cancer; ERONs

Full Text:



Králíčková M, Losan P, Vetvicka V. Endometriosis and cancer. Womens Health (Lond). 2014; 10(6): 591-7. doi: 10.2217/whe.14.43.

Anglesio MS, Yong PJ. Endometriosis associated Ovarian Cancers. Clin Obstet Gynecol. 2017; 60(4): 711-727. doi: 10.1097/GRF.0000000000000320.

Garavaglia E, Sigismondi C, Ferrari S, Candiani M4. The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions. Med Hypotheses. 2018 ;110 :80-82. doi: 10.1016/j.mehy.2017.11.006

Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies. Lancet Oncol. 2012; 13(4): 385–394. doi: 10.1016/S1470-2045(11)70404-1

Anglesio MS,i Bashashati A, Wang YK, Senz J, Ha G, Yang W, et al. Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden. J Pathol. 2015; 236(2): 201–209. doi: 10.1002/path.4516

Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014; 7(3): 349–357

Yuan Z, Cragun J, Chambers S, Zheng W, Wang Y. Cell origin of endometriosis: contribution by the fallopian tube epithelium. Am J Clin Exp Obstet Gynecol. 2013; 1(1): 37-42 ISSN:2330-1899/AJCEOG1310002

Shafrir AL, Farland LV, Shah DK, Harris HR, Kvaskoff M, Zondervan K, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018; 51:1-15. doi: 10.1016/j.bpobgyn.2018.06.001

Mori T, Ito F, Koshiba A, Kataoka H, Tanaka Y, Okimura H, et al. Aromatase as a target for treating endometriosis. J Obstet Gynaecol Res. 2018; 44(9): 1673-1681. doi: 10.1111/jog.13743.

Basta P, Koper K, Kazmierczak W, Wisniewski M, Makarewicz A, Dutsch-Wicherek M, et al. The biological role of Treg cells in ectopic endometrium homeostasis. Histol Histopathol. 2014; 29(10):1217-33. doi: 10.14670/HH-29.1217

Riccio LDGC, Santulli P, Marcellin L, Abrão MS, Batteux F, Chapron C. Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018; 50:39-49. doi: 10.1016/j.bpobgyn.2018.01.010

Gogacz M, Winkler I, Bojarska-Junak A, Tabarkiewicz J, Semczuk A, Rechberger T, et al. Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis. J Reprod Immunol. 2016; 117:39-44. doi: 10.1016/j.jri.2016.04.289

Izumi G, Koga K, Takamura M, Makabe T, Satake E, Takeuchi A, et al. Involvement of immune cells in the pathogenesis of endometriosis. J Obstet Gynaecol Res. 2018; 44(2):191-198. doi: 10.1111/jog.13559

Thiruchelvam U, Wingfield M, O'Farrelly C. Natural Killer Cells: Key Players in Endometriosis. Am J Reprod Immunol. 2015; 74(4):291-301. doi: 10.1111/aji.12408

Porpora MG, Scaramuzzino S, Sangiuliano C, Piacenti I, Bonanni V, Piccioni MG et al. High prevalence of autoimmune diseases in women with endometriosis: a case-control study. Gynecol Endocrinol. 2020 Apr;36(4):356-359. doi: 10.1080/09513590.2019.1655727

Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, et al. Meta-analysis Identifies Five Novel Loci Associated With Endometriosis Highlighting Key Genes Involved in Hormone Metabolism. Nat Commun. 2017; 24;8:15539. doi: 10.1038/ncomms15539

Gilabert-Estelles J, Braza-Boils A, Ramon LA, Zorio E, Medina P, Espana F, et al. Role of microRNAs in gynecological pathology. Curr Med Chem. 2012; 19(15) :2406-13. doi: 10.2174/092986712800269362

Maeda D, Shih IeM. Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms. Adv Anat Pathol. 2013; 20(1):45-52. doi: 10.1097/PAP.0b013e31827bc24d

Alcázar JL, Guerriero S, Ajossa S, Parodo G, Piras B, Peiretti M, et al. Extragenital endometrial stromal sarcoma arising in endometriosis. Gynecol Obstet Invest. 2012;73(4):265-71. doi: 10.1159/000336522.

Nezhat FR, Apostol R, Nezhat C, Pejovic T. New insights in the pathophysiology of ovarian cancer and implications for screening and prevention. Am J Obstet Gynecol. 2015; 213(3):262-7. doi: 10.1016/j.ajog.2015.03.044.

Ñiguez Sevilla I, Machado Linde F, Marín Sánchez MDP, Arense JJ, Torroba A, Nieto Díaz A, et al. Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer. J Gynecol Oncol. 2019; 30(4): e63. doi: 10.3802/jgo.2019.30.e63

Mangili G, Bergamini A, Taccagni G, Gentile C,

Panina P, Viganò P, et al. Unraveling the two entities of endometrioid ovarian cancer: a single center clinical experience. Gynecol Oncol. 2012; 126(3): 403-7. doi: 10.1016/j.ygyno.2012.05.007

Falconer H, Sundqvist J, Xu H, Vodolazkaia A, Fassbender A, Kyama C, et al. Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis. Gynecol Oncol. 2012; 127(2): 398-402. doi: 10.1016/j.ygyno.2012.08.013

Munksgaard PS, Blaakaer J.The association between endometriosis and ovarian cancer: a review of histological, genetic and molecular alterations. Gynecol Oncol. 2012 Jan;124(1):164-9. doi: 10.1016/j.ygyno.2011.10.001.

Wang S, Qiu L, Lang JH, et al. Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients. Am J Obstet Gynecol 2013 ;209: 241.e1-9 doi: 10.1016/j.ajog.2013.05.032

Vercellini P, Viganò P, Buggio L, Makieva S, Scarfone G, Cribiù FM, et al. Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated? Best Pract Res Clin Obstet Gynaecol. 2018; 51:151-168. doi: 10.1016/j.bpobgyn.2018.01.017

Wang C, Liang Z, Liu X, Zhang Q, Li S. The Association between Endometriosis, Tubal Ligation, Hysterectomy and Epithelial Ovarian Cancer: Meta-Analyses.Int J Environ Res Public Health. 2016; 14;13(11)

Kvaskoff M, Horne AW, Missmer SA. Informing women with endometriosis about ovarian cancer risk. Lancet. 2017 Dec 2;390(10111):2433-2434. doi: 10.1016/S0140-6736(17)33049-0.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014


POL-index 2011 - 2014


BASE 2011 - 2014




Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.



US NLM = 101679844

101679844 - NLM Catalog Result - NCBI


Find a library that holds this journal: http://worldcat.org/issn/23918306


PBN Poland






Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.


ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism