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Journal of Education, Health and Sport

Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats
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Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats

Authors

  • Oleksandr Popadynets’ State Enterprise Ukrainian Research Institute for Medicine of Transport, Odesa
  • Volodymyra Bilas State Enterprise Ukrainian Research Institute for Medicine of Transport, Odesa OO Bohomolets’ Institute of Physiology, Kyїv
  • Igor-Severyn Flyunt Ivan Franko State Pedagogical University, Drohobych
  • Nataliya Badiuk State Enterprise Ukrainian Research Institute for Medicine of Transport, Odesa
  • Walery Zukow Nicolaus Copernicus University in Torun, Torun
  • Anatoliy Gozhenko State Enterprise Ukrainian Research Institute for Medicine of Transport, Odesa
  • Igor Popovych OO Bohomolets’ Institute of Physiology, Kyїv

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.025

Keywords

Entropy of thymocytogram, splenocytogram, immunocytogram and leukocytogram, autonomic nervous, endocrine and immune parameters, female and male rats.

Abstract

Background. We have previously shown that the Entropy (E) of the Thymocytogram (T), Splenocytogram (S) as well as Leukocytogram (L) and Immunocytogram (I) of the blood in rats are virtually independent of each other. The purpose of this study was to clarify the characteristics of the condition of the neuroendocrine-immune complex in different constellations of E(s) of these four morpho-functional immune subsystems. Materials and methods. Experiment was performed on 108 healthy Wistar rats (48 male and 60 female) weighing 240-290 g divided into 8 groups. Animals of the first group remained intact. Instead, the other rats received various balneofactors for 6 days. The day after the completion of the drinking/application course the parameters of neuroendocrine-immune complex were registered. Results. The method of cluster analysis created four homogeneous groups of rats, significantly different from each other in the constellation of E of four morpho-functional immune subsystems. The members of the first cluster (n=31) are characterized by elevated levels of E (Z±SE) of I (1,12±0,16), T (1,00±0,14) and L (0,88±0,12) at the normal E level of S (0,14±0,16). The members of the second cluster (n=21) are characterized by reduced E level of L (-1,59±0,16) in combination with increased levels of I (0,80±0,17) and T (0,81±0,15) at the normal E level of S (0,13±0,16). A characteristic feature of the members of the third cluster (n=28) is reduced E of T (-1,01±0,17) at normal E levels of S (-0,33±0,23), I (-0,19± 0,14 ) and L (0,35±0,20). The last cluster (n=28) is characterized by reduced E of I (-1,36± 0,14), while the E of other immune subsystems are at the borderline levels: L (-0,52±0,16), S (0,49±0,15), T (0,60±0,15). The method of discriminant analysis revealed 15 parameters of the neuroendocrine-immune complex, the set of which four clusters of Entropies differ from each other with an accuracy of 95%. Conclusion. Each constellation of independent Entropies of the thymocytogram, splenocytogram, immunocytogram and leukocytogram is accompanied by a specific constellation of parameters of the neuroendocrine-immune complex which indicates their natural functional relationships.

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Published

2020-08-16

How to Cite

1.
POPADYNETS’, Oleksandr, BILAS, Volodymyra, FLYUNT, Igor-Severyn, BADIUK, Nataliya, ZUKOW, Walery, GOZHENKO, Anatoliy and POPOVYCH, Igor. Features of the condition of the neuroendocrine-immune complex in different constellations of entropies of morpho-functional immune subsystems in rats. Journal of Education, Health and Sport. Online. 16 August 2020. Vol. 10, no. 8, pp. 214-229. [Accessed 2 July 2025]. DOI 10.12775/JEHS.2020.10.08.025.
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Vol. 10 No. 8 (2020)

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