Adipose tissue and its proinflammatory properties

Waldemar Pluta, Aleksandra Radecka, Wioleta Dudzińska, Anna Lubkowska

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.08.016

Abstract


For many years, adipose tissue was considered only as an energy store, additionally having an insulating and protective function against injuries. The discovery of the ob gene more than 20 years ago meant that adipose tissue is now seen as an endocrine gland regulating / modulating the body's energy metabolism, inflammatory and immune processes thanks to the secretion of bioactive molecules such as adipokines, enzymes, hormones and growth factors. The substances secreted by adipose tissue with a pro-inflammatory effect include, among others leptin, resistin, tumor necrosis factor, lipocalin 2, angiopoietin-like protein, interleukin-6, interleukin-18, visfatin, monocyte chemotactic factor 1, chemerin or a plasminogen activator inhibitor.


Keywords


adipose tissue; immunology; inflammation

Full Text:

PDF

References


Myrda K, Rozentryt P, Nowak J, Niedziela J, Kawecka E, Poloński L. Tkanka tłuszczowa w niewydolności serca - wróg czy przyjaciel? Folia Cardiol. 2010;5:232–41.

Murawska-Ciałowicz E. Tkanka tłuszczowa-charakterystyka morfologiczna i biochemiczna różnych depozytów. Postep. Hig Med Dosw. 2017;71:466–84.

Matulewicz N, Karczewska-Kupczewska M. Insulinooporność a przewlekła reakcja zapalna. Postep. Hig Med Dosw. 2016;70:1245–57.

Sieminska L. Tkanka tluszczowa. Patofizjologia, rozmieszczenie, róznice plciowe oraz znaczenie w procesach zapalnych i nowotworowych. Endokrynol. Pol. 2007;58:330–42.

Heaton JM. The distribution of brown adipose tissue in the human. J. Anat. 1972;112:35–9.

Gonzalez-Barroso MDM, Ricquier D, Cassard-Doulcier A-M. The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. Obes. Rev. 2000;1:61–72.

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB et al. Identification and Importance of Brown Adipose Tissue in Adult Humans. N. Engl. J. Med. 2009;360:1509–17.

Wójcik B, Górski J. Brunatna tkanka tłuszczowa u dorosłego człowieka: występowanie i funkcja. Endokrynol. Otyłość i Zaburzenia Przemiany Mater. 2011;7:34–40.

Stosio M, Witkowicz A, Kowalska A, Karabon L. Genetic background of aberrant thermogenin expression (UCP1) in obesity leading to metabolic syndrome. Postepy Hig. Med. Dosw. (Online). 2016;70:1389–403.

Mazur A, Matusik P, Małecka-Tendera E. Tkanka tłuszczowa jako narza̧d wydzielania wewnȩtrznego. Pediatr. Pol. 2010;85:255–64.

Góralska M, Majewska-Szczepanik M, Szczepanik M. Mechanizmy immunologiczne towarzyszące otyłości i ich rola w zaburzeniach metabolizmu. Postepy Hig. Med. Dosw. 2015;69:1384–404.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–32.

Trayhurn P, Wang B, Wood IS. Hypoxia in adipose tissue: A basis for the dysregulation of tissue function in obesity? Br. J. Nutr. 2008;100:227–35.

Bouwman JJM, Visseren FLJ, Bouter KP, Diepersloot RJA. Infection-induced inflammatory response of adipocytes in vitro. Int. J. Obes. 2008;32:892–901.

Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Magdalena Olszanecka-Glinianowicz DNM, Patofi Zjologii Śląskiego K. Otyłość jako choroba zapalna Obesity as infl ammatory disease Word count. 2008:62.

Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive Action of Transmembrane TNFα in Adipose Tissue Leads to Reduced Adipose Mass and Local But Not Systemic Insulin Resistance. Endocrinology. 2002;143:1502–11.

Reaven G, Abbasi F, McLaughlin T. Obesity, insulin resistance, and cardiovascular disease. Recent Prog. Horm. Res. 2004;59:207–23.

Chacińska M, Zabielski P, Grycel S, Błachnio-zabielska A. Udział kwasów tłuszczowych i tkanki tłuszczowej w indukowaniu insulinooporności mięśni szkieletowych. Postep. Hig Med Dosw. 2016:1142–9.

Dyaczyński M, Scanes CG, Koziec H, Pierzchała-Koziec K. Endocrine implications of obesity and bariatric surgery. Endokrynol. Pol. 2018;69:574–86.

Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, MacIver NJ. Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity. J. Immunol. 2014;192:136–44.

Kazimierczak-Kabzińska A, Kajdaniuk D, Siemińska L, Nowak M, Głogowska-Szeląg J, Borgiel-Marek H et al. Selected adipose tissue hormones in the blood of patients with ischaemic cerebral stroke. Endokrynol. Pol. 2020;71:21–6.

Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes. 2004;53:1671–9.

Borsuk A, Biernat W, Zięba D. Multidirectional action of resistin in the organism. Postepy Hig. Med. Dosw. 2018;72:327–38.

Pęczek K, Nowicki M. Diagnostyka różnicowa ostrego uszkodzenia nerek. Varia Medica. 2017;1:57–64.

Wang Y, Lam KSLL, Kraegen EW, Sweeney G, Zhang J, Tso AW et al. Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans. Clin. Chem. 2007;53:34–41.

Moschen AR, Adolph TE, Gerner RR, Wieser V, Tilg H. Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation. Trends Endocrinol. Metab. 2017;28:388–97.

Law IKM, Xu A, Lam KSL, Berger T, Mak TW, Vanhoutte PM et al. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes. 2010;59:872–82.

Thorin-Trescases N, Thorin E. High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. 2017. doi:10.1155/2017/1096385.

Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol. 2011;11:85–97.

Niedźwiedzka-Rystwej P, Trzeciak-Ryczek A, Deptuła W. Tkanka tłuszczowa i jej rola w odporności - nowe dane. Alerg. Astma Immunol. 2012;17:16–21.

Gellen B, Thorin-Trescases N, Sosner P, Gand E, Saulnier PJ, Ragot S et al. ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients. Diabetologia. 2016;59:2321–30.

Mooney RA, Senn J, Cameron S, Boivin LM, Shang Y, Furlanetto RW. Suppressors of Cytokine Signaling-1 and-6 Associate with and Inhibit the Insulin Receptor A POTENTIAL MECHANISM FOR CYTOKINE-MEDIATED INSULIN RESISTANCE*. ASBMB. 2001. doi:10.1074/jbc.M010579200.

Ueki K, Kondo T, Kahn CR. Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms. Mol. Cell. Biol. 2004;24:5434–46.

Rieusset J, Bouzakri K, Chevillotte E, Ricard N, Jacquet D, Bastard JP et al. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Diabetes. 2004;53:2232–41.

Wajchenberg BL. Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome. Endocr. Rev. 2000;21:697–738.

Zahorska-Markiewicz B, Olszanecka-Glinianowicz M, Janowska J, Kocełak P, Semik-Grabarczyk E, Holecki M et al. Serum concentration of visfatin in obese women. Metabolism. 2007;56:1131–4.

Lu LF, Wang CP, Yu TH, Hung WC, Chiu CA, Chung FM et al. Interpretation of elevated plasma visfatin concentrations in patients with ST-elevation myocardial infarction. Cytokine. 2012;57:74–80.

Ilhan N, Susam S, Canpolat O, Belhan O. The emerging role of leptin, Adiponectin and Visfatin in Ischemic/Hemorrhagic stroke. Br. J. Neurosurg. 2019;33:504–7.

Kadoglou NPE, Fotiadis G, Lambadiari V, Maratou E, Dimitriadis G, Liapis CD. Serum levels of novel adipokines in patients with acute ischemic stroke: Potential contribution to diagnosis and prognosis. Peptides. 2014;57:12–6.

Pitoulias MG, Skoura L, Pitoulias AG, Chatzidimitriou D, Margariti A, Arsenakis M et al. The role of Visfatin in atherosclerotic peripheral arterial obstructive disease. Cytokine. 2017;91:140–4.

Chipitsyna G, Gong Q, Gray CF, Haroon Y, Kamer E, Arafat HA. Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells. Endocrinology. 2007;148:2198–208.

Tan H wei, Liu X, Bi X ping, Xing S shan, Li L, Gong H ping et al. IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome. Atherosclerosis. 2010;208:350–7.

Elhage R, Jawien J, Rudling M, Ljunggren HG, Takeda K, Akira S et al. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc. Res. 2003;59:234–40.

Netea MG, Joosten LAB, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat. Med. 2006;12:650–6.

Stojek M. Chemeryna – rola w patologii człowieka The role of chemerin in human disease. 2017:110–7.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism