Entropies of thymocytogram, splenocytogram, immunocytogram and leukocytogram in rats are regulated by sex and the neuroendocrine parameters while regulates immune parameters

Volodymyra Bilas, Oleksandr Popadynets’, Igor-Severyn Flyunt, Nadiya Sydoruk, Nataliya Badiuk, Serhiy Gushcha, Walery Zukow, Anatoliy Gozhenko, Igor Popovych

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.07.031

Abstract


Background. We have previously shown that the Entropy (E) of the relative spectral power density (SPD) of the EEG rhythms is its quite relevant parameter. We also found significant relationships between the SPD E of individual EEG loci and the E of the Leukocytogram (LCG) and Immunocytogram (ICG) of the blood, as well as with their individual components. The purpose of this study was to clarify the relationships between E(s) of these four morpho-functional immune subsystem and sex as well as parameters of the neuroendocrine-immune complex in rats. Materials and methods. Experiment was performed on 108 healthy Wistar rats (48 male and 60 female) weighing 205-300 g (M±SD=260±26 g) divided into 8 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received various balneofactors for 6 days. The day after the completion of the drinking/application course in all rats the parameters of neuroendocrine-immune complex were registered. Results. The drinking/application course did not affect the E level of any morpho-functional immune subsystem, the relationships between which are insignificant. Females have less E TCG than males, whereas sexual dimorphism is insignificant for E SCG and ICG and absent for E LCG. The canonical correlation of mediocre force (R=0,675) between sex index (M=1;F=2) and neuro-endocrine parameters (HRV, calcitonin, parathyroid and mineralocorticoid activities, corticosterone plasma, 17-KS urine) was revealed. Factors linked to female sex upregulates nine immune parameters (R=0,630), while downregulates nine others (R=0,678). The neuroendocrine constellation (testosterone plasma, HRV, calcitonin, parathyroid and mineralocorticoid activities) is associated with the constellation of entropies (R=0,533). Entropy of a single morpho-functional immune subsystem is associated with a certain constellation of immune parameters. In particular, E SCG with 12 (R=0,721), E TCG with 9 (R=0,615), E ICG with 8 (R=0,586), E LCG with 12 (R=0,631). Conclusion. Entropies of thymocytogram, splenocytogram, immunocytogram and leukocytogram in rats are regulated by sex and the neuroendocrine factors while regulates immune parameters.


Keywords


Entropy of thymocytogram; splenocytogram; immunocytogram and leukocytogram; autonomic nervous; endocrine and immune parameters; female and male rats.

Full Text:

PDF

References


Babelyuk VYe, Popadynets’ OO, Dubkova GI, Zukow W, Muszkieta R, Gozhenko OA, Popovych IL. Entropy of gas-discharge image correlates with the entropies of EEG, immunocytogram and leukocytogram but not HRV. Pedagogy and Psychology of Sport. 2020; 6(2): 30-39.

Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.

Bazarnova MA. Cytology investigation punctates spleen. In: Guide to practical training in clinical laboratory diagnostics [in Russian]. Kyiv: Vyshcha shkola; 1988: 263-264.

Belousova OI, Fedotova MI. Comparative data on changes in spleen, thymus and bone marrow lymphocyte counts in the early post-irradiation period over a wide range of doses [in Russian]. Radiobiology-Radiotherapy. 1968; 9(3): 309-313.

Bianco C. Population of lymphocytes bearing a membrane receptor for antigen-antibody complex. J Exp Med. 1970; 134(4): 702-720.

Bilas VR, Popovych IL. Role of microflora and organic substances of water Naftussya in its modulating influence on neuroendocrine-immune complex and metabolism [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(1): 68-102.

Biloshytskyi PV. Temperature, Information, Water, Anabiosis, Immortality [in Ukrainian]. Health and Longevity. Kyiv; 2007: 46-47.

Biloshytskyi PV, Biloshytskyi SP. Astrogeophysical aspects of bioinformation. [in Ukrainian]. Cosmos and the Biosphere. Partenit; 2003: 131-132.

Biloshytskyi PV, Biloshytskyi SP, Klyuchko OM. Conceptual Foundations of Bioinformation [in Ukrainian]. Cosmos and the Biosphere. Partenit; 2005: 141-142.

Chebanenko OI, Popovych IL, Chebanenko LO. Introduction to Information Balneology. Influence of Bioactive Water Naftussya of Truskavets’ Spa on Information Components of Neuroendocrine-immune Complex and Metabolism [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2011: 373 с.

Fil’ VM. Amelioration of “Truskavetsian” water with aloe extract [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(1): 156-162.

Flyunt IS, Chebanenko LO, Chebanenko OI, Kyjenko VM, Fil’ VM. Experimental balneophytotherapy [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2008: 196 p.

Goryachkovskiy AM. Clinical biochemi [in Russian]. Odesa: Astroprint; 1998: 608 p.

Gozhenko OA, Zavidnyuk YV, Korda MM, Mysula IR, Klishch IM, Zukow W, Popovych IL. Features of neuro-endocrine and immune reactions to various water-salt loads in female rats. Journal of Education, Health and Sport. 2018; 8(9): 11-31.

Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200 p.

Huchko BYa. Immune accompaniment of polyvariant post-stress changes in blood plasma atherogenicity in rats [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(4): 73-83.

Instructions for the use of a set of reagents for the enzyme-linked immunosorbent assay in human serum. St. Petersburg: Alkor Bio CJSC; 2000: 50 p.

Jondal M, Holm G, Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972. 136;(2): 207-215.

Khaitov RM. Physiology of the Immune System [in Russian]. Мoskwa: VINITI RAS; 2005: 428 p.

Kostyuk PG, Ivassivka SV, Fil’ VM, Il’nyts’ka-Rybchych ТО, Kyjenko VM, Flyunt IS. Physiological Activity of the Health Drink "Truskavetsian Crystal with Aloe" [in Ukrainian]. Drohobych. Posvit; 2007: 144 p.

Kozyavkina OV, Kozyavkina NV, Gozhenko OA, Gozhenko AI, Barylyak LG, Popovych IL. Bioactive Water Naftussya and Neuroendocrine-Immune Complex [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2015: 349 p.

Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and Immunogram. Journal of Education, Health and Sport. 2017; 7(3): 53-71.

Kyrylenko IG, Flyunt I-SS, Fil’ VM, Zukow W, Popovych IL. Changes in electrokinetic index of buccal epithelium correlated with changes in some parameters of immunity and fecal microbiocenosis. Journal of Education, Health and Sport. 2018; 8(10): 168-170.

Limatibul S., Shore A., Dosch H.M., Gelfand E.W. Theophylline modulation of E-rosette formation: an indicator of T-cell maturation. Clin Exp Immunol. 1978; 33(3): 503-513.

Lukyanchenko OI, Gozhenko OA, Mel’nyk OI, Zukow W, Popovych IL. Features of the immune profile and microbiota in persons whose immune status is susceptible or resistant to chronic stress. Journal of Education, Health and Sport. 2019; 9(3): 601-611.

Perederiy VG, Zemskov AM, Bychkova NG, Zemskov VM. Immune status, principles of its evaluation and correction of immune disorders [in Russian]. Kyiv: Zdorovya; 1995: 211 p.

Polovynko IS, Zajats LM, Popovych AI, Popovych IL. Іntegral quantification of neuroendocrine and immune responses to chronic stress in male rats [in Ukrainian]. In: Pathophysiology and Pharmacy: ways of integration: Abstracts VII National Congress pathophysiologists Ukraine with international participation (5-7 October 2016). Kharkiv: NPhU, 2016: 182.

Polovynko IS, Zayats LM, Zukow W, Popovych IL. Neuro-endocrine-immune relationships by chronic stress at male rats. Journal of Health Sciences. 2013; 3(12): 365-374.

Polovynko IS, Zajats LM, Zukow W, Yanchij RI, Popovych IL. Quantitative evaluation of integrated neuroendocrine and immune responses to chronic stress in rats male. Journal of Education, Health and Sport. 2016; 6(8): 154-166.

Polovynko IS, Zukow W. Variety of immune responses to chronic stress in rats male. Journal of Education, Health and Sport. 2016; 6(12): 843-856.

Popadynets’ OO. Factor analysis of the information field of parameters of nervous regulatory structures and immunity. Focus on their entropy [in Ukrainian]. Bulletin of Marine Medicine. 2020; 2(87): 7-18.

Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(5): 651-666.

Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Interpersonal differences between of the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(6): 534-545.

Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Peculiarities of spectral parameters of EEG, HRV and routine parameters of immunity in patients with various levels of the entropy of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(8): 617-636.

Popadynets’ OO, Gozhenko AI, Badiuk NS, Zukow W, Kovbasnyuk MM, Korolyshyn TA, Popovych IL. Relationships between changes in entropy of the EEG and parameters of the immunity. Pedagogy and Psychology of Sport. 2020; 6(1): 24-40.

Popadynets’ O, Gozhenko A, Badyuk N, Popovych I, Skaliy A, Hagner-Derengowska M, Napierata M, Muszkieta R, Sokołowski D, Zukow W, Rybałko L. Interpersonal differences caused by adaptogen changes in enropies of EEG, HRV, immunocytogram, and leukocytogram. Journal of Physical Education and Sport. 2020; 20(Suppl. 2): 982-999.

Popovych AI. Features of the immunotropic effects of partial components of the balneotherapeutic complex of spa Truskavets’. Journal of Education, Health and Sport. 2018; 8(12): 919-935.

Popоvych IL. Information effects of bioactive water Naftyssya in rats: modulation entropic, prevention desynchronizing and limitation of disharmonizing actions water immersion stress for information components of neuro-endocrine-immune system and metabolism, which correlates with gastroprotective effect [in Ukrainian]. Medical Hydrology and Rehabilitation. 2007; 5(3): 50-70.

Popovych IL. Stress-limiting effects of bioactive Naftussya water under chronic restrictive stress in rats [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(3): 128-153.

Popovych IL. Influence of balneotherapy at Truskavets’ spa on adaptive-protective systems of persons with disadaptosis and immunodysfunction [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(2): 71-87.

Popovych IL. Stresslimiting Adaptogene Mechanism of Biological and Curative Activity of Water Naftussya [in Ukrainian]. Kyiv: Computerpress; 2011: 300 p.

Popovych IL, Gozhenko AI, Zukow W, Polovynko IS. Variety of Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. Scholars' Press. Riga; 2020: 172 p.

Popovych IL, Gumega MD, Verba IE, Popovych AI, Korolyshyn TA, Tkachuk SP, Ostapenko VM, Zukow W. Comparative investigation effects on nervous and immune systems of bioactive water Naftussya spa Truskavets’ and stable water solution of Boryslav’s ozokerite. Journal of Education, Health and Sport. 2016; 6(4): 364-374.

Popovych IL, Kul’chyns’kyi AB, Korolyshyn TA, Zukow W. Interrelations between changes in parameters of HRV, EEG and cellular immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(10): 11-23.

Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.

Popovych IL, Polovynko IS, Zajats LM, Mel’nyk OI. Sexual dimorphism of the neuroendocrine-immune complex and its reactions on chronic stress at rats. Experimental and Clinical Physiology and Biochemistry. 2018; 3(83): 5-17.

Popovych IL, Sydoruk NO, Gozhenko AI, Zukow W. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on neuro-endocrine parameters at humans with dysadaptation. Journal of Education, Health and Sport. 2017; 7(2): 465-478.

Shannon CE. Works on the theory of informatics and cybernetics. Moskwa: Inostrannaya literatura; 1963: 329 p.

Struk ZD, Mel’nyk OI, Zukow W, Popovych IL. The diversity of immune reactions to balneotherapy and their accompaniments. Journal of Education, Health and Sport. 2019; 9(11): 349-373.

Sydoruk NO, Chebanenko ОІ, Zukow W, Popovych IL. Comparative Study of Physiological Activity of Naftussya Water Truskavets’ and Pomyarky Deposits [in Ukrainian]. Кyiv. UNESCO-SOCIO; 2018: 176 p.

Yushkovs’ka OG. Using information theory to study adaptive responses in the body athletes [in Ukrainian]. Medical Rehabilitation, Kurortology, Physiotherapy. 2001; 1(25): 40-43.

Zajats LM, Polovynko IS, Zukow W. Features neuro-endocrine support diversity of immune responses to chronic stress in male rats. Journal of Education, Health and Sport. 2017; 7(3): 97-105.

Zajats LM, Polovynko IS, Zukow W, Yanchij RI,. Mysakovets’ OG, Mel’nyk OI, Hrytsak YaL. Neuroendocrine-immune relatioships in rats females. Journal of Education, Health and Sport. 2017; 7(10): 59-78.

Zavidnyuk YV, Mysula IR, Klishch IM, Zukow W, Popovych IL, Korda MM. General non-specific metabolic, neuroendocrine and immune reactions to various water-salt loads in female rats. Journal of Education, Health and Sport. 2018; 8(3): 513-524.

Zukow W, Popadynets’ OO, Gozhenko AI, Popovych IL. Interpersonal differences in parameters of the EEG and HRV in the humans with various levels of the entropy of the EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(7): 448-466.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism