Phage therapy in osteoarticular infections in the era of antibiotic resistance bacteria

Jakub Czarnota, Michał Dobrzyński, Tomasz Wojciech Skubel, Dorota Sokół, Iga Dudek, Małgorzata Drozd, Halina Piecewicz-Szczęsna

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.07.012

Abstract


The increase in the incidence rate of multidrug resistant strains of bacteria has prompted scientists to look for alternatives to antibiotics. One option is phage therapy. The possibility of using phages (bacteriophages) in infections of almost every organ and system is being investigated. The treatment of osteoarticular infections using antibiotics is often very problematic, which is why this is an important area of interest for phage research.

As part of the bacteriophage experimental therapy conducted by Patey et al., 9 patients with osteoarticular diseases were treated. In 7 cases complete recovery was obtained. One patient achieved partial eradication of the pathogen with closure of several fistulas and stabilization of the general condition.

The study was carried out on an animal model by Yilmaz et al. showed greater effectiveness in eliminating MRSA colony forming units when combining bacteriophages with antibiotics (drop to 5000 units, no biofilm) than when using antibiotics alone (17,165 units survived, biofilm present). Independent application of phage therapy brought the worst effect (30,788 surviving units).

The results of the cited studies indicate the possible effectiveness of phage therapy in the case of osteoarticular infections. The potential synergy of antibiotics and bacteriophages in eradicating bacterial biofilm deserves attention.


Keywords


bacterial infection; antibiotic resistance; bacteriophage; antibiotic therapy; phage therapy

Full Text:

PDF

References


O. Patey, S. McCallin, H. Mazure, M. Liddle, A. Smithyman, and A. Dublanchet, “Clinical indications and compassionate use of phage therapy: Personal experience and literature review with a focus on osteoarticular infections,” Viruses, vol. 11, no. 1, Jan. 2019.

D. Myelnikov, “An Alternative Cure: The Adoption and Survival of Bacteriophage Therapy in the USSR, 1922–1955,” J. Hist. Med. Allied Sci., vol. 73, no. 4, p. 385, 2018.

V. La Fauci and V. Alessi, “Antibiotic resistance: Where are we going?,” Ann. di Ig., vol. 30, no. 4, pp. 52–57, 2018.

D. M. Lin, B. Koskella, and H. C. Lin, “Phage therapy: An alternative to antibiotics in the age of multi-drug resistance,” World J. Gastrointest. Pharmacol. Ther., vol. 8, no. 3, p. 162, 2017.

C. Yilmaz, M. Colak, B. C. Yilmaz, G. Ersoz, M. Kutateladze, and M. Gozlugol, “Bacteriophage therapy in implant-related infections: An experimental study,” J. Bone Jt. Surg. - Ser. A, vol. 95, no. 2, pp. 117–125, Jan. 2013.

B. Koskella and S. Meaden, “Understanding Bacteriophage Specificity in Natural Microbial Communities,” Viruses, vol. 5, no. 3, pp. 806–823, Mar. 2013.

M. G. Weinbauer, “Ecology of prokaryotic viruses,” FEMS Microbiology Reviews, vol. 28, no. 2. Oxford Academic, pp. 127–181, 01-May-2004.

L. Zhang et al., “Intracellular Staphylococcus aureus control by virulent bacteriophages within MAC-T bovine mammary epithelial cells,” Antimicrob. Agents Chemother., vol. 61, no. 2, Feb. 2017.

S. A. Sarker et al., “Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh,” EBioMedicine, vol. 4, pp. 124–137, Feb. 2016.

P. Leszczyński, B. Weber-Da̧browska, M. Kohutnicka, M. Łuczak, A. Górecki, and A. Górski, “Successful eradication of methicillin-resistant Staphylococcus aureus (MRSA) intestinal carrier status in a healthcare worker - Case report,” Folia Microbiol. (Praha)., vol. 51, no. 3, pp. 236–238, May 2006.

E. Jończyk-Matysiak et al., “Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes,” Front. Microbiol., vol. 8, p. 164, Feb. 2017.

V. V. Morozova, Y. N. Kozlova, D. A. Ganichev, and N. V. Tikunova, “Bacteriophage treatment of infected diabetic foot ulcers,” in Methods in Molecular Biology, vol. 1693, Humana Press Inc., 2018, pp. 151–158.

P. Jault et al., “Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial,” Lancet Infect. Dis., vol. 19, no. 1, pp. 35–45, Jan. 2019.

T. Rose et al., “Experimental phage therapy of burn wound infection: difficult first steps.,” Int. J. Burns Trauma, vol. 4, no. 2, pp. 66–73, 2014.

P. Speck and A. Smithyman, “Safety and efficacy of phage therapy via the intravenous route,” FEMS Microbiol. Lett., vol. 363, no. 3, Feb. 2016.

R. T. Schooley et al., “Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection,” Antimicrob. Agents Chemother., vol. 61, no. 10, Oct. 2017.

L. Leitner et al., “Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: A randomized, placebo-controlled, double-blind clinical trial,” BMC Urol., vol. 17, no. 1, pp. 1–6, Sep. 2017.

L. D. R. Melo et al., “Development of a phage cocktail to control Proteus mirabilis catheter-associated urinary tract infections,” Front. Microbiol., vol. 7, no. JUN, p. 1024, 2016.

G. Zhang et al., “Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients,” Int. Forum Allergy Rhinol., vol. 8, no. 3, pp. 406–414, Mar. 2018.

S. A. Fong et al., “Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients,” Front. Cell. Infect. Microbiol., vol. 7, no. SEP, p. 418, Sep. 2017.

A. Malik, Z. Mohammad, and J. Ahmad, “The diabetic foot infections: Biofilms and antimicrobial resistance,” Diabetes Metab. Syndr. Clin. Res. Rev., vol. 7, no. 2, pp. 101–107, Apr. 2013.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism