Influence of PRP on morphological changes in muscle in the early period after traumatic muscle injury in the experiment

Volodymyr Dzhyvak, Oksana Khlibovska, Tamara Datsko, Ivan Klishch

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.06.019

Abstract


The aim of our study was to investigate the effectiveness of the use of platelet-rich plasma on morphological changes in muscle tissue in traumatic muscle injury in the experiment.
Materials and methods of research. We analyzed the results of histological analysis of the muscle tissue of animals in an experiment in traumatic muscle injury treated with platelet-rich plasma. Depending on the treatment received, the animals were divided into: the first group - with traumatic thigh muscle injury without PRP correction (20 rats), the second group with traumatic thigh muscle injury with PRP correction (20 rats), the third group - control (20 intact rats). Preparation of PRP took place in two stages.
Results and discussion. As a result of the conducted researches it was established that the introduction of PRP showed differences in morphological features on the seventh day at the beginning of the process of muscle recovery, compared with the first experimental group. There are signs of regeneration, while the muscle fibers are still in the process of formation and without vascularization. This morphological descriptive analysis confirms that in the group, which was treated PRP, was the best organization of the process of restoring muscle.
Conclusions
1.In traumatic muscle injury in experimental animals, structural changes in muscle tissue begin to develop from the first day of the experiment throughout the study period and are manifested by severe circulatory disorders and the development of dystrophic - necrotic changes, especially in epithelial structures, reaching a maximum on the seventh day.
2.The introduction of PRP affects the better organization of the muscle recovery process.


Keywords


traumatic muscle injury; PRP; regeneration

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References


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