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Journal of Education, Health and Sport

Influence of PRP on morphological changes in muscle in the early period after traumatic muscle injury in the experiment
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  • Influence of PRP on morphological changes in muscle in the early period after traumatic muscle injury in the experiment
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Influence of PRP on morphological changes in muscle in the early period after traumatic muscle injury in the experiment

Authors

  • Volodymyr Dzhyvak I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil
  • Oksana Khlibovska I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil
  • Tamara Datsko I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil
  • Ivan Klishch I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil

DOI:

https://doi.org/10.12775/JEHS.2020.10.06.019

Keywords

traumatic muscle injury, PRP, regeneration

Abstract

The aim of our study was to investigate the effectiveness of the use of platelet-rich plasma on morphological changes in muscle tissue in traumatic muscle injury in the experiment.
Materials and methods of research. We analyzed the results of histological analysis of the muscle tissue of animals in an experiment in traumatic muscle injury treated with platelet-rich plasma. Depending on the treatment received, the animals were divided into: the first group - with traumatic thigh muscle injury without PRP correction (20 rats), the second group with traumatic thigh muscle injury with PRP correction (20 rats), the third group - control (20 intact rats). Preparation of PRP took place in two stages.
Results and discussion. As a result of the conducted researches it was established that the introduction of PRP showed differences in morphological features on the seventh day at the beginning of the process of muscle recovery, compared with the first experimental group. There are signs of regeneration, while the muscle fibers are still in the process of formation and without vascularization. This morphological descriptive analysis confirms that in the group, which was treated PRP, was the best organization of the process of restoring muscle.
Conclusions
1.In traumatic muscle injury in experimental animals, structural changes in muscle tissue begin to develop from the first day of the experiment throughout the study period and are manifested by severe circulatory disorders and the development of dystrophic - necrotic changes, especially in epithelial structures, reaching a maximum on the seventh day.
2.The introduction of PRP affects the better organization of the muscle recovery process.

Author Biographies

Volodymyr Dzhyvak, I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil

PhD, postgraduate student of the Department of Pathological Physiology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Oksana Khlibovska, I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil

MD, PhD, Associate Professor of the Obstetrics and Gynaecology

Department I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

Tamara Datsko, I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil

MD, PhD, Associate Professor of the Department of Pathologic Anatomy, Autopsy Course and Forensic Pathology I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Ivan Klishch, I. Horbachevsky Ternopil National Medical University of the MOH of Ukraine, Ternopil

Prof., DSc, PhD, MD Professor of Department of Functional and Laboratory Diagnostics I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

References

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Lessons from a large trauma center: impact of blunt chest trauma in polytrauma patients–still a relevant problem? / K. Chrysou et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2017. Vol. 25, № 1. Р. 42.

Jørgensen U. The role of rules and refereeing in injury prevention / U. Jørgensen // Sport injuries. Basic principles of prevention and treatment. - Kiev: Olympus. Lit., 2002. - P. 184–189.

Methods of morphological researches: monograph / Bagriy M., Dibrova V., Popadinets O., Grishchuk I., ed. M. Bagriy, V. Dibrovy. - Vinnitsa: Nova Knyga, 2016. - 238 p.

Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes // Official Journal of the European Union. – 2010. – L276. – Р. 33–79.

Guide for the care and use of laboratory animals. – 8th ed. Washington : The National Academies Press, 2011. – 246 p.

Platelet-Rich Plasma Adrian D.K. Le, MD, Lawrence Enweze, MD, Malcolm R. DeBaun, MD, Jason L. Dragoo, MD. Clinics in Sports Medicine. January 2019. Volume 38, Issue 1, Pages 17–44. DOI: https://doi.org/10.1016/j.csm.2018.08.001

Dzhyvak, V. H., Klishch, I. M., Datsko, T. V., Khlibovska, O. I. Morphofunctional changes in the lungs and liver in the early period after traumatic muscle injury in the experiment // Achievements of clinical and experimental medicine.-2020.-1.-P.74-77. https://doi.org/10.11603/1811-2471.2020.v.i1.11072 https://ojs.tdmu.edu.ua/index.php/zdobutky-eks-med/article/view/11072

Setayesh, K., Villarreal, A., Gottschalk, A. et al. Treatment of Muscle Injuries with Platelet-Rich Plasma: a Review of the Literature. Curr Rev Musculoskelet Med 11, 635–642 (2018). https://doi.org/10.1007/s12178-018-9526-8

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Published

2020-06-23

How to Cite

1.
DZHYVAK, Volodymyr, KHLIBOVSKA, Oksana, DATSKO, Tamara and KLISHCH, Ivan. Influence of PRP on morphological changes in muscle in the early period after traumatic muscle injury in the experiment. Journal of Education, Health and Sport. Online. 23 June 2020. Vol. 10, no. 6, pp. 171-178. [Accessed 6 July 2025]. DOI 10.12775/JEHS.2020.10.06.019.
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Vol. 10 No. 6 (2020)

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Research Articles

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