Deep brain stimulation in Parkinson's disease - the review

Patryk Piotr Jasielski, Faustyna Piędel, Klaudia Szumna, Dominika Madras, Agata Rocka



Introduction: Parkinson’s disease (PD) is a common neurodegenerative disorder and is the second most common neurodegenerative disease after Alzheimer’s disease. The clinical features are associated with motor symptoms: tremor, rigidity, and bradykinesia with postural instability. PD is also associated with many non-motor symptoms, and these often precede the motor symptoms by years or even decades. In general, treatment is based on usage of medicaments which increase a level of dopamine. Surgical therapy is reserved for more advanced cases. Objective: To review currently available data on PubMed about a surgical treatment of Parkinson’s disease and future prospects. Abbreviated description of the state of knowledge: Surgical therapy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. Currently, the most common surgical treatment for Parkinson's disease is deep brain stimulation (DBS). Ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. We also analyzed future prospects including cells transplantation. DBS decreases a level of disability, depression and increases quality of life. It should to take under consideration in early as well as advanced PD. Conclusions: PD is still incurable, however both pharmacological and surgical treatment can stifle the progression of disease for years and increase quality of life. New methods of treatment are promising. However, the further research about possible therapy is required.


Parkinson's disease; treatment; surgery; new therapy

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Kalia LV, Lang AE. Parkinson’s disease. Lancet. 2015 29; 386(9996): 896–912.

Tanner CM, Goldman SM. Epidemiology of Parkinson’s disease. Neurol Clin. 1996 May; (2): 317–35.

Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003; 348(14): 1356–64.

Lees AJ, Hardy J, Revesz T. Parkinson’s disease. Lancet. 2009; 373(9680): 2055–66.

Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature. 1997; 388(6645): 839–40.

Williams-Gray CH, Worth PF. Parkinson’s disease. Medicine. 2016; 44(9): 542–6.

Cooper IS. Chemopallidectomy: an investigative technique in geriatric parkinsonians. Science. 1955; 121: 217–218.

Hassler R, Riechert T. Indications and localization of stereotactic brain operations. Nervenarzt. 1954; 25: 441–447.

Narabayashi H, Okuma T. Procaine-oil blocking of the globus pallidus for the treatment of rigidity and tremor of parkinsonism. Proc Jpn Acad. 1953; 29: 134–137.

Brice J, McLellan L. Suppression of intention tremor by contingent deep-brain stimulation. Lancet. 1980; 1: 1221–1222.

Deep-Brain Stimulation for Parkinson's Disease Study Group: Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med. 2001; 345: 956-63

Ory S, Le Jeune F, Haegelen C, Vicente S, Pierre Philippot et al. Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease. J neuropsych. 2017; 11 (3): 378-395.

Gee L, Smith H, De La Cruz P, et al. The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in Parkinson's Disease Patients. Stereotact Funct Neurosurg. 2015; 93(4): 265–270.

Zong H, Meng F, Zhang Y, Wei G, Zhao H. Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease. Clin Interv Aging. 2019; 14: 1159–1166.

Hacker ML, DeLong MR, Turchan M, et al. Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease. Neurology. 2018; 91(5): e463–e471.

Hacker ML, Currie AD, Molinari AL, et al. Subthalamic Nucleus Deep Brain Stimulation May Reduce Medication Costs in Early Stage Parkinson's Disease. J Parkinsons Dis. 2016; 6(1): 125–131.

Birchall EL, Walker HC, Cutter G, et al. The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease. Brain Stimul. 2017; 10(3): 651–656.

Blomstedt P, Stenmark Persson R, Hariz GM, et al. Deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson's disease: a randomised blinded evaluation. J Neurol Neurosurg Psychiatry. 2018; 89(7): 710–716.

Gratwicke J, Zrinzo L, Kahan J, et al. Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia: A Randomized Clinical Trial. JAMA Neurol. 2018;75(2):169–178.

Deep brain stimulation. American Association of Neurological Surgeons. 2018.

Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science. 1979; 204(4393): 643-7.

Canesi M, Giordano R, Lazzari L, et al. Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy. J Transl Med. 2016; 14(1): 127.

Leng L, Tian Z. Transplantation of Neural Precursor Cells in the Treatment of Parkinson Disease: An Efficacy and Safety Analysis. Turk Neurosurg. 2016; 26(3): 378-83.

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