Analysis of the relationship between the activity of inducible nitric oxide synthase and interleukin-1 in the pathogenesis of experimental diabetic retinopathy
DOI:
https://doi.org/10.12775/JEHS.2020.10.01.035Keywords
experimental diabetic retinopathy, endothelial dysfunction, inflammation, inducible oxide synthase, interleukin 1β.Abstract
The purpose of the study: analysis of changes in the development of hypoxia and endothelial dysfunction in experimental diabetic retinopathy. Our results indicate endothelial dysfunction and dysfunction of nitric oxide synthesis on the 30th day of development of experimental diabetic retinopathy. An increase in the activity of inducible nitric oxide synthase in the 2nd group (p <0.001) in the first stage of the experiment with further progression of pathological changes on the 60th and 180th day of the study. The development of the inflammatory process in experimental diabetic retinopathy has been revealed and its relationship with the increase in the activity of inducible nitric oxide synthase has been confirmed. The most pronounced increase in the studied cytokine was detected in the 3rd stage of the experiment (p <0,001).
References
Susla OB, Misula IR, Gozhenko AI. Strukturno-funkcional'ni zmini endoteliju i kal'cinoz sercevih klapaniv u pacijentiv iz hronichnoju hvoroboju nirok do provedennja dializu. Krovoobig ta gemostaz. 2011;3-4(33-34):64-68.
Pashkovs'ka NV, Pashkovs'kij VM. Cukrovij diabet i mozkovij insul't: suchasnij pogljad na problemu. Mizhnarodnij endokrinologichnij zhurnal. 2018;14(4):11-22.
Kuznecova AS, Gozhenko AI, Kuznecova ES, Shuhtin VV, Kuznecova EN, Kuznecov SG. Jendotelij. Fiziologija i patologija: monografija. Odessa: «Feniks», 2018. 284 s.
Pavlova ON Investigation of the dynamics of catalase activity in the blood serum of rats under mechanical action on the blood-ophthalmic barrier / ON Pavlova, ON Gulenko, RG Karimova, etc. // International research journal. - 2020. - № 5 (95) Часть 1.-С.153—158.
Bykov IL The effect of L-carnitine on metabolic disorders in experimental deficiency of acyl-CoA dehydrogenases. Experimental and clinical pharmacology. 2004. - Volume 67 - № 6. P.48-52.
Lupan IV, Avramenko OV, Akbash KS Computer statistical packages: a textbook. - 2nd type. - Kirovograd: "CODE" 2015. - 236 p.
E. I. Kurilina, D. S. Churjumov. Rol' metabolicheskogo zvena oksida azota v mehanizmah razvitija glaukomnoj opticheskoj nejropatii i perspektivy nejroprotekcii pri glaukome: sovremennye aspekty. Mezhdunarodnyj medicinskij zhurnal, 2013, № 1. S.53-59.
Flammer J. Glaucoma / J. Flammer.— Bern: Verlag Hans Huber, 2001.— 416 p.
Metabolicheskaja koncepcija patogeneza glaukomatoznoj opticheskoj nejropatii / N. I. Kurysheva, N. A. Markicheva, A. M. Deev, g. A. Shilkin // Fedorovskie chtenija-2003. Nauchno-prakticheskaja konferencija «Sovremennye tehnologii lechenija glaukomy».— M., 2003.— S. 87–96.
Oksid azota v patogeneze katarakty i glaukomy /N. I. Kurysheva, I. K. tomilova, A. A. Deev, S. B. Nazarov // Vestn. oftal'mologii.— 2001.— № 5.— S. 5–7.
Stuehr D. J. Enzymes of the L-arginine to nitric oxide pathway / D. J. Stuehr // J. Nutr.— 2004.— Vol. 134.— P. 2748–2751.
McSorley S. J. Nitric oxide pathway / S. J. McSorley, F. Y. Liew // Encyclopedia of Immunology; ed. P. J. Delves, J. M. Roitt.— N. Y.: Academic Press.— 2004.— P. 1859–1851.
Neufeld A. Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase / A. Neufeld, S. Kawai, S. Das // Exp. Eye Res.— 2002.— Vbl. 75.— P. 521–528.
Vyjavlenie i ocenka depo NO v organizme bodrstvujushhej krysy / S. Ju. Mashina, A. F. Vanin, V. A. Serezhenkov [i dr.] // Bjulleten' jeksperimental'noj biologii i mediciny.— 2003.— t. 136, № 7.— S. 32–36.
Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation / M. T. Gladwin, N. J. Raat, S. H. Shiva [et al.] // Am. J. Physiol. Heart Circ. Physiol.— 2006.— Vol. 291.— P. 2026–2035.
Forstermann U. Nitric oxide synthases: regulation and function / U. Forstermann, W.C. Sessa // European Heart Journal. – 2012. – V. 33. – P. 829-837.
Daff S. NO synthase: structures and mechanisms / S. Daff // Nitric Oxide. – 2010. – V.23, N 1. – P. 1-11.
T. A. Perceva, E. Ju. Gashinova, N. A. Efimova. Vlijanie kurenija na koncentraciju oksida azota v vydyhaemom vozduhe u pacientov s hronicheskim obstruktivnym zabolevaniem legkih. Ukraїns'kij pul'monologіchnij zhurnal. 2010, № 3. S.19-21.
T.A. Rozhdestvenskaja, S.S. Lazuko. Vlijanie inducibel'noj NO-sintazy i oksida azota v syvorotke krovi beremennyh s arterial'noj gipertenziej na sostojanie plodovogo krovotoka.Problemy reprodukcii, 5, 2015. S.127-131.
Kietadisorn R, Juni Rio P, Moens AnL. Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities. Am Endocrinolology and Metabolism. 2012;302(5):E481-E495. doi.org/10.1152/ajpendo.00540.20.11
Matjakubova S.A. Sovremennye vozmozhnosti profіlaktiki gestacionnoj gipertenzii. Molodoj uchenyj. 2014;10:80-85
Nitric oxide and redox mechanisms in the immune response / David A. Wink, Harry B. Hines, Robert Y. S. Cheng [et al.] // J Leukoc Biol. – 2011. – № 89(6). – R. 873– 891.
Belaja A. Ju., Krasnosel'skij N. V. Ocenka jedotelial'noj disfunkcii i sostojanie soedinitel'noj tkani u bol'nyh s rakom molochnoj zhelezy. Harkіvs'ka hіrurgіchna shkola № 6(75) 2015. S.92-96.
Steelman L. S. Akt as a therapeutic target in cancer / L. S. Steelman, K. M. Stadelman, W. H. Chappell [et al.] // ExpertOpin Ther Targets — 2008. — Vol. 12. — P. 1139–65.
Zhou X. Activation of the Akt/mammalian target of rapamycin / 4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers / X. Zhou, M. Tan, V. Stone Hawthorne [et al.] // Clin Cancer Res — 2004. — Vol. 10. — P. 6779–88.
Zhao J. Signal transduction by focal adhesion kinase in cancer / J. Zhao, J. L. Guan // Cancer Met Rev — 2009. — Vol. — 28. — P. 35–49.
Akіmova V.M. Citokіnovij spektr krovі pri gostromu destruktivnomu apendicitі / V.M. Akіmova // Vіsnik problem bіologії і medicini. – 2012. – T.2(95), Vip.3. – S. 36 - 39.
Nikitin E.V. Suchasnі ujavlennja pro sistemu citokіnіv / Nikitin E.V., Chaban T.V., Serveckij S.K. // Іnfekcіjnі hvorobi. - 2013. - №2 – S. 64-69.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 414
Number of citations: 0