Opportunities for the use of natural and preformed physical factors in the complex treatment of patients with chronic viral hepatitis C with associated non-alcoholic fatty liver disease

Аnna Izha

DOI: http://dx.doi.org/10.12775/JEHS.2019.09.12.026


One of the urgent problems of modern hepatology remains the treatment of patients with chronic viral hepatitis C, which is associated with an increase in the incidence and development of complications - cirrhosis of the liver and hepatocellular carcinoma. The presence of non-alcoholic fatty liver disease in patients accelerates the progression rate of HCV infection and reduces the effectiveness and tolerability of antiviral therapy. The above circumstances initiated us to the search for new non-drug technologies for the treatment of this category of patients.  The work aimed to evaluate the effectiveness of the integrated use of standard antiviral therapy, drinking silicon low-mineralized sodium bicarbonate mineral water, and EHF-therapy in patients with chronic viral hepatitis C with concomitant non-alcoholic fatty liver disease. We used the following methods: anamnestic, general clinical, biochemical, serological, immunological, Ultrasonographic examination of the digestive organs. We examined 42 patients who were divided into two groups. The control group (22 people) received the basic treatment complex, which included dietary nutrition, standard antiviral therapy for 12 months, and an internal intake of mineral water during the first month of treatment. The main group (20 people), in addition to the basic complex of treatment, additionally received EHF-therapy procedures for three months. Evaluation of the effectiveness of treatment was carried out after 1 and 3 months from the start of treatment. The treatment was accompanied by the positive dynamics of most signs of the disease in both groups, with a predominance of EHF-therapy. In patients of main group, the disappearance of complications of antiviral therapy was established - the absence of cytopenic syndrome, normalization of immunological status, stimulation of interferonogenesis, restoration of equilibrium in the lipid peroxidation system and antioxidant system. These positive results made it possible to complete the course of therapy for all patients and obtain a virological response in 50% of patients.


chronic viral hepatitis C; non-alcoholic fatty liver disease; mineral water; EHF-therapy

Full Text:



Coppola N, Alessio L, Onorato L. et al. Epidemiology and management of hepatitis C virus infections in immigrant populations. Infect Dis Poverty. 2019;8(17). https://doi.org/10.1186/s40249-019-0528-6.

Ringehan М, McKeating JA, Protzer U. Viral hepatitis and liver cancer. Philos Trans R Soc Lond B Biol Sci. 2017.Oct.19;372(1732):20160274. doi: 10.1098/rstb.2016.0274.

Kralj D, Jukić LV, ljević SS, Duvnjak М, Smolić М, Čurčić IB. Hepatitis C Virus, Insulin Resistance, and Steatosis. J Clin Transl Hepatol. 2016;4(1):66–75. doi: 10.14218/JCTH.2015.00051.

Sumida Y., Kanemasa К, Hara Т, Inada Y, Sakai K, et al. Impact of amino acid substitutions in hepatitis C virus genotype 1 b core region on liver steatosis and glucose tolerance in noncirrhotic patients without. Journal of Gastroenterology and Hepatology. 2011;26(5):836–842.

Min HK, Kapoor А, Fuchs М, Mirshahi F, Zhou H, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell metabolism. 2012;15(5):665–74. doi: 10.1016/j.cmet.2012.04.004.

Fedorchenko SV. Chronic HCV infection: a monograph. Kiev: Medicine. 2010:272 р. https://www.medpublish.com.ua/hronicheskaja-hcvinphekcija-monographija-sv-phedorchenko/p-685.html?language=ru.

Brillanti S, Mazzella G, Roda Е. Ribavirin for chronic hepatitis C: And the mystery goes on. Digestive and Liver Diseases. 2011;43(6):425–430. doi: https://doi.org/10.1016/j.dld.2010.10.007.

Mineral healing waters. State standard technical specifications 42.10-02-96. [Valid from 1996-06-24]. Kyiv: Ministry of Health of Ukraine. 1996. 30 p. (Industry standard of Ukraine).

Fedorova T, Efimenko N, Kaĭsinova A. Balneotherapeutics of non-alcoholic fatty liver disease with the use of the Essentuki-type drinking mineral waters. Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury. 20102;6:21–23. https://www.researchgate.net/publication/282020735_Balneotherapeutics_of_non-alcoholic_fatty_liver_disease_with_the_use_of_the_Essentuki-type_drinking_mineral_waters

EASL-EASD-EASO Clinical Practice Guidelines for the management of nonalcoholic fatty liver disease. J Hepatology. 2016; 64(6):1388—1402. doi: 10.1016/j.jhep.2015.11.004.

Dragomiretskaya NV, Zabolotnaya IB, Izha AN, Kalinichenko NV, Zukow W. Feasibility of combined use of antiviral therapy and health resort factors in patients with chronic hepatitis C. Journal of Health Sciences. 2011;1(3):135-136.

Zunnunov Z R. The effectiveness of the application of medicinal mineral water from the 'Omonkhona' source in the patients presenting with the diseases of the hepatobiliary system. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2019;96(1):22. DOI: 10.17116/kurort20199601122

Zabolotna IB, Gushcha SG, Mikhailenko VL. Non-alcoholic fatty liver disease and mineral waters of Ukraine – opportunities of application (experimental-clinical studies). Balneo Research Journal. 2018;9(3):270–276. http://bioclima.ro/Balneo194.pdf.

Al-Muяafar HM, Amil KA. Alteration of Serum and Hepatic Trace Element Level in non-alcoholic Fatty liver Disease – induced by High – fat Sucrose Diet. Asian Journal of Scientifical Researcher/ 2019;12(3):323-332. DOI: 10.3923/ajsr/2019.323.332.

Citelli M, Fonte-Faria T, Nascimento-Silva V. Obesity Promotes Alterations in Iron Recycling. Nutrients. 2015;7(1):335-348. https://doi.org/10.3390/nu7010335.

Dragomiretska NV, Shevchenko NA, Izha AN, Zabolotnaya IB, Kalinichenko NV, Zukow W. Application of natural and physical factors is in treatment of patients with chronic viral hepatitis of С - ground of the use. Journal of Health Sciences. 2013;3(4):153–163. https://odmu.edu.ua/xmlui/bitstream/handle/123456789/5981/Dragomiretska.pdf?sequence=1&isAllowed=y.

Fizioterapiya i kurortologiya [Physiotherapy and balneology] Pod redaktsiey V.M. Bogolyubova. Kniga I. – M.: Izdatelstvo BINOM, 2008. – S. 408.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014


POL-index 2011 - 2014


BASE 2011 - 2014




Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.



US NLM = 101679844

101679844 - NLM Catalog Result - NCBI


Find a library that holds this journal: http://worldcat.org/issn/23918306


PBN Poland






Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.


ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48


Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism