Vegetative, endocrine and metabolic accompaniments of individual immune responses to adaptogenic balneotherapy

Oksana Mel’nyk, Zoryana Struk, Walery Zukow, Igor Popovych

DOI: http://dx.doi.org/10.12775/JEHS.2019.09.12.023

Abstract


Background. Earlier in clinical observations four variants of the immune responses to adaptogenic balneotherapy at the Truskavets’ spa have been identified. In 40,9% of patients, initially normal immune status did not change significantly; in 31,8%, the lower boundary level of immunity is completely normalized; in 22,7% moderate immunosuppression is reduced, but not up to normal; however, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors. The purpose of this study is to analyze vegetative, endocrine and metabolic accompaniments of individual immune responses to balneofactors of Truskavets’ spa. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking bioactive water Naftussya three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO. The state of the autonomic nervous system is estimated by HRV ("CardioLab+HRV"). To assess endocrine status we determined plasma levels of principal adaptation Hormones: Cortisol, Testosterone and Triiodothyronine (ELISA). We determined also the plasma and daily urine levels of the electrolytes: calcium, phosphates, sodium, potassium, magnesium and chloride as well as nitrous metabolites creatinine, urea and uric acid. According to the parameters of electrolyte exchange, parathyroid, calcitonin and mineralocorticoid hormonal activities was evaluated. We estimated also plasma lipide spectrum. Results. 13 immunosuppressive and 6 immune-enhancing neuro-endocrine and metabolic parameters identified. Discriminant analysis conducted to identify parameters, in which the four immune response clusters differ significantly from each other. 25 parameters are characteristic, 12 of them related to the HRV, 5 to endocrine, 5 to electrolytes and 3 to nitrous metabolites exchange. Conclusion. Individual immune responses to adaptogenic balneofactors are accompanied by characteristic changes in the parameters of the autonomic nervous and endocrine systems, as well as the exchange of electrolytes, nitrogen metabolites and lipids.


Keywords


Individual immune responses; HRV; hormones; electrolytes; nitrogen metabolites; lipids; balneotherapy; Truskavet’s spa.

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References


Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.

Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.

Chavan SS, Pavlov VA, Tracey KJ. Mechanism and therapeutic relevance of neuro-imune communication. Immunity. 2017; 46: 927-942.

Chavan SS, Tracey KJ. Essencial Neuroscience in Immunology. J Immunol. 2017; 198: 3389-3397.

Douglas SD, Quie PG. Investigation of Phagocytes in Disease. Churchil; 1981: 110 p.

Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa: Astroprint; 1998: 608 p.

Gozhenko AI. Functional-metabolic continuum [in Russian]. J NAMS of Ukraine. 2016; 22(1): 3-8.

Gozhenko AI, Sydoruk NO, Babelyuk VYe, Dubkowa GI, Flyunt VR, Hubyts’kyi VYo, Zukow W, Barylyak LG, Popovych IL. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on some metabolic and biophysic parameters at humans with dysfunction of neuro-endocrine-immune complex. Journal of Education, Health and Sport. 2016; 6(12): 826-842.

Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200 p.

Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.

Hiller G. Test for the quantitative determination of HDL cholesterol in EDTA plasma with Reflotron®. Klin Chem. 1987; 33: 895-898.

Hrytsak YaL, Barylyak LG, Zukow W, Popovych IL. Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions. Journal of Education, Health and Sport. 2016; 6(4): 141-150.

Khaitov RM, Pinegin BV, Istamov KhI. Ecological Immunology [in Russian]. Мoskwa: VNIRO; 1995: 219 p.

Klecka WR. Discriminant Analysis [trans. from English to Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva: Finansy i Statistika; 1989: 78-138.

Kostyuk PG, Popovych IL, Іvassivka SV (editors). Chornobyl’, Adaptive and Defensive Systems, Rehabilitation [in Ukrainian]. Kyiv. Computerpress; 2006: 348 p.

Kotelnikov SA, Nozdrachov AD, Odinak MM, Shustov EB, Kovalenko IYu, Davidenko VYu. Heart rate variability: understanding of the mechanisms [in Russian]. Fiziologiya cheloveka. 2002; 28(1): 130-143.

Kul’chyns’kyi AB, Kovbasnyuk MM, Korolyshyn TA, Kyjenko VM, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 2. Correlations between parameters EEG, HRV and Phagocytosis. Journal of Education, Health and Sport. 2016; 6(10): 377-401.

Kul’chyns’kyi AB, Struk ZD, Gozhenko AI, Yanchij RI, Zukow WA, Kovbasnyuk MM, Korolyshyn TA, Popovych IL. Interrelations between changes in parameters of HRV, EEG and immunity. In: Mater XX Congress of the Ukrainian Physiological Society named after PG Kostyuk. Fiziol Zhurn. 2019; 65(3). Suppl: 184-185.

Lapovets’ LY, Lutsyk BD. Handbook of Laboratory Immunology [in Ukrainian]. Lviv; 2002: 173 p.

Mel’nyk OI, Struk ZD. Predictors of individual immune responses to adaptogens. Experimental and Clinical Physiology and Biochemistry. 2019; 88(4): 5-15.

Pavlov VA, Chavan SS, Tracey KJ. Molecular and functional neuroscience in immunity. Annu Rev Immunol. 2018; 36: 783-812.

Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(5): 651-666.

Popovych AI. Features of the neurotropic effects of partial components of the balneotherapeutic complex of spa Truskavets’. Journal of Education, Health and Sport. 2019; 9(1): 396-409.

Popovych IL. Functional relationships between parameters of neuro-endocrine-immune complex at male rats [in Ukrainian]. Achivements of Clinical and Experimental Medicine. 2008; 2(9): 80-87.

Popovych IL. The concept of neuro-endocrine-immune complex (review) [in Russian]. Medical Hydrology and Rehabilitation. 2009; 7(3): 9-18.

Popovych IL. The factor and canonical analysis parameters of neuro-endocrine-immune complex, metabolism and erosive-ulcerose injuries of mucous stomach at rats in conditions of acute water immersing stress [in Ukrainian]. Medical Hydrology and Rehabilitation. 2007; 5(2): 68-80.

Popovych IL, Gumega MD, Verba IE, Popovych AI, Korolyshyn TA, Tkachuk SP, Ostapenko VM, Zukow W. Comparative investigation effects on nervous and immune systems of bioactive water Naftussya spa Truskavets’ and stable water solution of Boryslav’s ozokerite. Journal of Education, Health and Sport. 2016; 6(4): 364-374.

Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.

Sternberg EM. Neural regulation of innate immunity: a coordinated nonspecific response to pathogens. Nat Rev Immunol. 2006; 6(4): 318-328.

Struk ZD. Neuroendocrine and clinical accompaniment of various immunotropic effects of bioactive water Naftussya [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(4): 51-65.

Struk ZD, Mel’nyk OI, Zukow W, Popovych IL. The diversity of immune reactions to balneotherapy and their accompaniments. Journal of Education, Health and Sport. 2019; 9(11): 349-373.

Struk ZD, Mel’nyk OI, Mysakovets’ OG. Individual immune responses to adaptogens and their predictors. In: Rehabilitation Medicine and Health-Resort Institutions Development. Proceedings of the 19th International Applied Research Conference (Kyїv, 11-12 December 2019). Edited by O. Gozhenko, W. Zukow. Toruń, Kyiv. 2019: 83-84.

Sydoruk NO, Zukow W. Differences between the effects of water Naftussya from fields of Truskavets’ and Pomyarky on the parameters of the EEG, HRV, immunity and metabolism. Journal of Education, Health and Sport. 2019; 9(1): 287-293.

Thayer JF, Sternberg EM. Neural aspects of immunomodulation: Focus on the vagus nerve. Brain Behav Immun. 2010; 24(8): 1223-1228.

Uchakin PN, Uchakina ON, Tobin BV, Yershov FI. Neuroendocrine Immunomodulation [in Russian]. Vestnik Ross AMN. 2007; 9: 26-32.


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