The level of endogenic intoxication in the dynamics of development of experimental contact dermatitis and experimental pneumonia and their correction by thiotriazoline
DOI:
https://doi.org/10.12775/JEHS.2019.09.11.026Keywords
contact dermatitis, pneumonia, endogenous intoxication, thiotriazolineAbstract
Тhe aim of our work was to find out the peculiarities of changes ofendogenous intoxication indices in guinea pig blood during theformation of combined pathology - experimental contact dermatitis and experimental pneumonia and correction of their disorders with thiotriazoline.The paper found a gradual increase in the molecules of mediummass and erythrocyte index of intoxication in guinea pig serum with experimental contact dermatitis and experimental pneumonia with the highest degree of expression on the 18thday of the experiment, and this may be may indicate the development of endogenous intoxication of the animal body. At the same time, the use of the drug thiotriazoline caused the decrease of the studied indicators, which gives grounds to stateits positive effect on certain markers of endogenous intoxicationand the feasibility of further research.References
Volkova V.A., Kuchynska I.V., Tiupka T.I. Study of the therapeutic efficacy of a new ointment with a lipophilic complex of the Tremulin aspen bark under conditions of non-allergic contact dermatitis in rats. Pharmacology and drug toxicology. 2010;7–12.
Kolishetska M.A Characteristic of individual indicators of endogenous intoxication in the experimental asthma dynamics and their correction by thiotriazolin. EUREKA :Health Sciences. 2016. Vol. 6, № 6. P. 52–56.
Shlyapnykov V.N., Solodova T.L. et al. Eksperimentalnye modeli ostrykh pnevmoniy, vyzvanykh uslovno-patolohicheskimi bakteriyami I ikh assotsiatsiey: metod. ukazaniya sost. Saratov, 1998. 30 p.
Volchegorskiy, I. A., Diatlov, D. A., Lvovskaya, E. I. et. al. (1997). Middle molecules" as probable regulators of erythrone system in skiers. Lab. Diagnostic, 1, 11–16.
Shmoilov, D. K., Karimov, I. Z., Odynets, T. N. (2012). Pathogenic role of endogenous intoxication. Lab. Diagnostic, 2, 65–69.
Kostner, L., Anzengruber, F., Guillod, C., Recher, M., Schmid-Grendelmeier, P., & Navarini, A. A. (2017). Allergic contact dermatitis. Immunology and Allergy Clinics, 37 (1), 141-152.
Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association B. Cao, Y. Huang, D.Y. She, Q.J. Cheng, H. Fan, X.L. Tian, et al. Clin Respir J, 12 (2018), pp. 1320-1360
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