Influence of mineral water of well No. 3 of Semyanivka village of Poltava district of Poltava region (Ukraine) on the structural and functional state of the kidneys with experimental nephritis

S. Gushcha, B. Nasibullin, W. Zukow, I. Balashova, К. Koieva, V. Volyanska, M. Arabaji



In an experiment on white rats with toxic nephritis, pathological changes in the structural and functional state of the kidneys were determined. An increase in the daily diuresis (p <0.001) was found, due to an increase in the glomerular filtration rate by (p <0.001) and a significant decrease in the percentage of fluid back-suction (p <0.001). The excretion of creatinine and urea increased by (p <0.01), and the excretion of chloride ions, on the contrary, decreased (p <0.01). Application on the background of the development of low-mineralized silicon chloride-hydrocarbonate sodium water leads to partial normalization of kidney function - the volume of diuresis is moderately restored by increasing the tubular reabsorption against the background of a significant increase in the glomerular filtration rate and a significant increase in the amount of silica. The manifestations of inflammation in the kidneys disappear, but the destructive changes of the nephrons remain. The partial restoration of the activity of redox enzymes has been established.


mineral water; structural and functional state kidneys; experimental nephritis.

Full Text:



Cruz MC, Andrade C, Urrutia M, Draibe S, Nogueira-Martins lA. Quality of life in patients with chronic kidney disease. Clinics (Sao Paulo). 2011;66(6):991 – 995. doi: 10.1590/s1807-59322011000600012.

Matsushita К, Chen J, Sang Y, Ballew SH, Shimazaki R, Fukagawa M, Imai E, Coresh J., Hishida A. Risk of end-stage renal disease in Japanese patients with chronic kidney disease increases proportionately to decline in estimated glomerular filtration rate. Kidney Int. 2016;90(5):1109 – 1114. doi: 10.1016/j.kint.2016.08.003.

Vakulenko LI. Pylonephritis in girls: features at the modern stage. Ukranian Journal of Nephrology and Dialysis. 2018;1(57):38 – 43.


Yamawaki K., Kanda H., ShimazakI R. Nrf2 activator for the treatment of kidney diseases. Toxicology and Applied Pharmacology. 2018. Vol. 360. P. 30 – 37.

Petraccia L, Liberati GL, Masciullo SG, Grassi М, Fraioli А. Water, mineral waters and health. Clin Nutr. 2006:25(3):377 – 385. doi: 10.1016/j.clnu.2005.10.002.

Zolotareva TA, Babov KD, Nasibullin BA, Kozyavkin VI, Torokhtin AM, Yushkovskaya OG. Medical rehabilitation. Kyiv: КІМ, 2012. 496 р.

Zabolotna IB, Gushcha SG, Mikhailenko VL. Non-alcoholic fatty liver disease and mineral waters of Ukraine – opportunities of application (experimental-clinical studies). Balneo Research Journal. 2018;9(3):270 – 276.

doi: 10.12680/balneo.2018.194.

Moiseev AYu. Features of the chemical composition and balneological use of mineral waters / Ed. by VP. Shestopalova, NP. Moiseeva. Kiev: KIM, 2017. 446 р.

Medical-hydrogeochemical factors of geological environment in Ukraine / Ed by HI. Rudko. Kyiv - Chernovtsy: Bukrek, 2015: 724 р.

Rakhmanin YuA, Egorova NA, Krasovsky GN, Mikhailova RI., Alekseeva AV. Silicon: its biological impact under dietary intake and hygienic standardization of its content in drinking water. A review. Hygiene & Sanitation (Russian Journal). 2017; 96(5) DOI:

Santra S., Guha P. K., Ali S. Z., Haneef I., Udrea F. Silicon on insulator diode temperature sensor – A detailed analysis for ultra-high temperature operation. IEEE Sensor J. 2010;10(5): 997 – 1003.

Jurkic LM, Cepanec I, Pavelic SK, Pavelic K. Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid – releasing compounds: New perspectives for therapy. Nutrition & Metabolism. 2013;10(2).

Dzhioev IG. The influence of TIB-2 mineral water on the secretion of gastrin and pepsin, on the state of g-cells of the stomach. International Journal of Applied and Fundamental Research. 2017;7(1):84-86. URL:

Gushcha SG. Tо the mechanisms of correcting influence of mineral waters of different osmolyarity and microelement composition on the structural-functional state of kidneys of rats with experimental nephritis. Bulletin of problems biology and medicinе. 2018;2(144):301 – 306.


Instruction 2010/63/EU of European Parliament and Council on animals used for research and other purposes protection. Official Journal. 2010;276:33–79.

Order of MOH of Ukraine No. 692 dated 28.09.2009 «On approval of the recommendations of the research methods of biological effects of natural medicinal resources and preformed remedies».

Nasibullin BA, Gushcha SG, Babov KD, Trubka IO. еt al A guide to the reproduction of experimental models of common nosological forms and their verification]. Odessa. 2018:82 р.

Order of MOH of Ukraine No. 692 dated 28.09.2009 «On approval of the recommendations of the research methods of biological effects of natural medicinal resources and preformed remedies».

Mineral healing waters. Technical conditions GSTU 42.10.02-96. Kiev: State Standard of Ukraine, 1996. 30 р.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism