Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Role of the lipid peroxidation in immunomodulating effects of the nitrogenous metabolites in rats
  • Home
  • /
  • Role of the lipid peroxidation in immunomodulating effects of the nitrogenous metabolites in rats
  1. Home /
  2. Archives /
  3. Vol. 11 No. 4 (2021) /
  4. Research Articles

Role of the lipid peroxidation in immunomodulating effects of the nitrogenous metabolites in rats

Authors

  • Anatoliy Gozhenko Ukrainian Scientific Research Institute for Medicine of Transport, Odesa
  • Igor Kuchma Ukrainian Scientific Research Institute for Medicine of Transport, Odesa
  • Sofiya Ruzhylo Ivan Franko Pedagogical University, Drohobych
  • Galyna Kovalchuk Ivan Franko Pedagogical University, Drohobych
  • Walery Zukow Nicolaus Copernicus University, Torun
  • Igor Popovych Bohomolets’ OO Institute of Physiology of National Academy of Sciences, Kyїv

DOI:

https://doi.org/10.12775/JEHS.2021.11.04.015

Keywords

uric acid, creatinine, urea, bilirubin, lipid peroxidation, ANS, hormones, immunity, relationships, rats.

Abstract

Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects, but the question of mediators of the immunomodulation remains open. We hypothesized the mediating role of mediators of the autonomic nervous system and adaptation hormones as well as reactive oxygen species. Mediating role in the immunomodulation of neuroendocrine factors is analyzed in a previous article. The aim of this study is to analyze the relationships between the parameters of nitrogenous metabolites and lipid peroxidation as well as between latter and immune parameters subordinate modulations by nitrogenous metabolites. Material and methods. Experiment was performed on 60 healthy female Wistar rats. The plasma level and urinary excretion of the nitrogenous metabolites as well as parameters of lipid peroxidation (diene conjugates, malonic dyaldehid, superoxide dismutase, catalase) and neuroendocrine-immune complex were determined. Results. According to the canonical correlation analysis, the constellation of nitrogenous metabolites determines the state of lipid peroxidation by 38,8%. The latter, in turn, determines the constellation of immune parameters (subject to modulation by nitrogenous metabolites) by 61,4%. On the other hand, the coefficient of determination between nitrogenous metabolites and neuroendocrine parameters is 71,5%, and between the latter and immune status – 89,6%. Taken together, neuroendocrine parameters and lipid peroxidation parameters determine the pool of immune parameters subject to modulation by nitrogenous metabolites by 96,7%. It was previously shown that the coefficient of determination between nitrogenous metabolites and a number of immune parameters is 95,8%. Conclusion. The obtained results, taken together with the previous ones, prove that uric acid, bilirubin, urea and creatinine realize their immunomodulatory effects both directly through receptors of immunocytes (aryl hydrocarbon, adenosine and TL) and with the participation of mediators of autonomic nervous and endocrine systems and lipid peroxidation.

References

Andreyeva LI, Kozhemyakin LA, Kishkun AA. Modification of the method for determining the lipid peroxide in the test with thiobarbituric acid [in Russian]. Laboratornoye Delo. 1988; 11: 41-43.

Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.

Dubinina YY, Yefimova LF, Sofronova LN, Geronimus AL. Comparative analysis of the activity of superoxide dismutase and catalase of erythrocytes and whole blood from newborn children with chronic hypoxia [in Russian]. Laboratornoye Delo. 1988; 8: 16-19.

Gavrilov VB, Mishkorudnaya MI. Spectrophotometric determination of plasma levels of lipid hydroperoxides [in Russian]. Laboratornoye Delo. 1983; 3: 33-36.

Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa. Astroprint; 1998: 608 p.

Gozhenko AI. Functional-metabolic continuum [in Russian]. J of NAMS of Ukraine. 2016; 22 (1): 3-8.

Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Popovych IL. Functional relationships between parameters of uric acid exchange and immunity in female rats. Actual problems of transport medicine. 2019; 4(58): 123–131.

Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Popovych IL. Features of immune status in different states of uric acid metabolism in female rats. Journal of Education, Health and Sport. 2019; 9(12): 167-180.

Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction. Journal of Education, Health and Sport. 2020; 10(1): 165-175.

Gozhenko AI, Smagliy VS, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction. Journal of Education, Health and Sport. 2020; 10(2): 212-222.

Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200 p.

Instructions for use of a set of reagents for enzyme-linked immunosorbent assay of hormones in human blood [in Russian]. SPb. CJSC “Alcor Bio”; 2000.

Korolyuk MA, Ivanova MI, Mayorova IG, Tokarev VYe. The method for determining the activity of catalase [in Russian]. Laboratornoye Delo. 1988; 1: 16-19.

Kuchma IL, Gozhenko AI, Bilas VR, Huchko BY, Ponomarenko RB, Nahurna YV, Zukow W, Popovych IL. Relationships between parameters of nitrogenous metabolites and HRV in humans exposed to the factors of the accident at the Chоrnobyl nuclear power plant. Journal of Education, Health and Sport. 2021; 11(1): 253-268.

Kuchma IL, Gozhenko AI, Bilas VR, Ruzhylo SV, Kovalchuk GY, Nahurna YV, Zukow W, Popovych IL. Immunotropic effects of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) in humans exposed to the factors of the accident at the Chоrnobyl nuclear power plant. Journal of Education, Health and Sport. 2020; 10(12): 314-331.

Kuchma IL, Gozhenko AI, Flyunt ISS, Ruzhylo SV, Nahurna YV, Zukow W, Popovych IL. Role of the autonomic nervous system and lipoperoxidation in immunotropic effects of nitrogenous metabolites in patients with postradiation encephalopathia. Journal of Education, Health and Sport. 2021; 11(2): 145-155.

Kuchma IL, Gozhenko AI, Flyunt ISS, Ruzhylo SV, Kovalchuk GY, Zukow W, Popovych IL. Role of the neuroendocrine complex in immunotropic effects of nitrogenous metabolites in rats. Journal of Education, Health and Sport. 2021; 11(3): 212-230.

Kul’chyns’kyi AB, Kyjenko VM, Zukow W, Popovych IL. Causal neuro-immune relationships at patients with chronic pyelonephritis and cholecystitis. Correlations between parameters EEG, HRV and white blood cell count. Open Medicine. 2017; 12(1): 201-213.

Kul’chyns’kyi AB, Zukow W, Korolyshyn TA, Popovych IL. Interrelations between changes in parameters of HRV, EEG and humoral immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(9): 439-459.

Lukyanchenko OI, Mel’nyk OI, Gozhenko OA, Zukow W, Popovych IL. Features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress. Journal of Education, Health and Sport. 2020; 10(3): 177-187.

Makarenko YeV. A comprehensive definition of the activity of superoxide dismutase and glutathione reductase in red blood cells in patients with chronic liver disease [in Russian]. Laboratornoye Delo. 1988; 11: 48-50.

Mel’nyk OI, Struk ZD, Zukow W, Popovych IL. Vegetative, endocrine and metabolic accompaniments of individual immune responses to adaptogenic balneotherapy. Journal of Education, Health and Sport. 2019; 9(12): 207-229.

Morelli M, Carta AR, Kachroo A, Schwarzschild A. Pathophysiological roles for purines: adenosine, caffeine and urate. Prog Brain Res. 2010; 183: 183-208.

Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system. Brain Behav Immun. 2007; 21(6): 736-745.

Popovych IL, Gozhenko AI, Kuchma IL, Zukow W, Bilas VR, Kovalchuk GY, Ivasivka AS. Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats. Journal of Education, Health and Sport. 2020; 10(11): 320-336.

Popovych IL, Gozhenko AI, Zukow W, Polovynko IS. Variety of Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. Scholars' Press. Riga; 2020: 172 p.

Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.

Popovych IL, Kul’chyns’kyi AB, Korolyshyn TA, Zukow W. Interrelations between changes in parameters of HRV, EEG and cellular immunity at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2017; 7(10): 11-23.

Smagliy VS, Gozhenko AI, Korda IV, Badiuk NS, Zukow W, Kovbasnyuk MM, Popovych IL. Variants of uric acid metabolism and their immune and microbiota accompaniments in patients with neuroendocrine-immune complex dysfunction. Actual problems of transport medicine. 2020; 1(59): 114–125.

Sternberg EM. Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol. 2006; 6(4): 318-328.

Thayer JF, Sternberg EM. Neural aspects of immunomodulation: Focus on the vagus nerve. Brain Behav Immun. 2010; 24(8): 1223-1228.

Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007; 117(2): 289-296.

Gozhenko A., Biryukov V., Gozhenko O., Zukow, W. Health as a space-time continuum. Journal of Education, Health and Sport, 2018; 8(11): 763-777. DOI: http://dx.doi.org/10.5281/zenodo.2657000.

Gozhenko A., Biryukov V., Muszkieta R., Zukow, W. Physiological basis of human longevity: the concept of a cascade of human aging mechanism. Collegium antropologicum, 2018; 42(2): 139-146.

Downloads

  • PDF

Published

2021-04-30

How to Cite

1.
GOZHENKO, Anatoliy, KUCHMA, Igor, RUZHYLO, Sofiya, KOVALCHUK, Galyna, ZUKOW, Walery and POPOVYCH, Igor. Role of the lipid peroxidation in immunomodulating effects of the nitrogenous metabolites in rats. Journal of Education, Health and Sport. Online. 30 April 2021. Vol. 11, no. 4, pp. 144-156. [Accessed 8 July 2025]. DOI 10.12775/JEHS.2021.11.04.015.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 11 No. 4 (2021)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 571
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

uric acid, creatinine, urea, bilirubin, lipid peroxidation, ANS, hormones, immunity, relationships, rats.
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop