Changes of non-specific resistance in patients with postoperative peritonitis with abdominal sepsis

Abstract

Purpose: to study changes in nonspecific resistance and cytokine regulation in patients with postoperative peritonitis with abdominal sepsis

Materials and methods. The clinic treated 456 patients with postoperative peritonitis who were treated in the surgery department of the municipal non-profit enterprise Regional Clinical Hospital of Ivano-Frankivsk Regional Council in the period from 2000 to 2021. Immunological studies were performed in 66 patients with varying severity of abdominal sepsis and its complications.

Research results and their discussion. In patients with postoperative peritonitis with abdominal sepsis, the phagocytic index during the first week of hospital stay was in control. However, on the 10th-11th day, the phagocytic index decreased 1.6 times, which progressed until the end of the third week of treatment - on the 14th-21st day, the phagocytic index was 2.7 times smaller than the control. The phagocytic count in patients with PP with abdominal sepsis reached maximum values in the first day of the disease (3 ± 0.26). Later in the treatment process, this figure gradually decreased and on day 14-21 came to normal and amounted to 1.96 ± 0.10. The index of completeness of phagocytosis on the first day of the disease was1,59 ± 0,20. By 2-3 days it decreased by 1.44 ± 0.20 and returned to normal by 14-21 days. Circulating immune complexes were normalized by 5-7 days of the disease.