The effect of thiotriazoline on impaired immune system in experimental pneumonia and contact dermatitis

Abstract

Literary sources indicate that various pathological processes are accompanied by the development of a violation of the immune system.

The aim of the study was to determine the pathogenetic justification for the use of thiotriazoline on the basis of immune system disorders in experimental pneumonia (EP) and contact dermatitis (CD).The researches were carried out on 55 guinea-pigs. The study material was collected on the 4th, 8th, 10th and 18th days of EP and ECD under ether anesthesia. EP was called by the method of VN Shlyapnikov, TL Solodov. ECD was simulated by method of VA Volkovoj. The content of T and B lymphocytes in the blood was determined by the method of Chernushenko KF, Kogosova LS, and the level of the circulating immune complexes (CIC) by the method of V. Haskova, J. Kaslik. We have established a gradual increase in the level of B-lymphocytes and CIC against the background of a decrease in T-lymphocytes in the blood on the 4th, 8th, 10th and 18th days of the development of EP and CD, with a predominance on the 18th day of the experiment before treatment. The use of thiotriazoline caused an immunocorrective effect in CD and EP.