New risc factors in progression of age-related macular degeneration
DOI:
https://doi.org/10.12775/JEHS.2020.10.10.009Keywords
age-related macular degeneration, platelet’s receptors, model of prediction of complicationsAbstract
Background. Allot of studies investigate the etiology and pathogenesis of age-related macular degeneration (AMD). The exudative form of AMD is the leading cause of irreversible blindness in the elderly. At the same time neurosensory retina detachment in AMD has high level of prevalence and severity of comlications but little attention has been paid to explaying the risk factors of retina edema and the possibility of their role on the interstitial fluid accumulation. The investigation of patterns for predicting the risk of retinal detachment is still cosiderable, as this is important for patients selection with high risk of developing retinal detachment of AMD and effective preventive treatment.
Purpose: To investigate new risk factors for the progression of age-related macular degeneration.
Materials and methods. The prospective study included 37 patients (67 eyes) with the exudative form of AMD (Category 4 according to the AREDS). 21 (56.8%) patients had exudative detachment of neurosensory retina. The ophthalmologic examination included anamnesis, visometry, tonometry, biomicroscopy, ophthalmoscopy and optical coherence tomography. ATP, ADP, adenosine, platelet-activating factor (PAF), adrenaline and isadrin were used to study the functional activity of platelet receptors. The evaluation of platelet aggregation was carried out by a turbidimetric method. Methods of pair correlation analysis and multiple linear regression models were used to analyse the relationship between the values of individual agonists the retinal detachment.
Results. After analysis of nine items, three of which were found to be significantly associated with serous detachment of neurosensory retina, including the activity of PAF receptors, adenosine A2A receptors and α2-adrenoreceptors. The prognosis of the cases of this complication in the general cohort of patients with exudative AMD turned out to be positive in 87.5%.
Conclusions. Correlation between the development of exudative detachment of neurosensory retina and the functional state of Pl can be used in the selection for preventive treatment of patients with retinal detachment in AMD.
References
Tso MOM., Suarez MJ.,, Eberhart CG. Pathologic study of early manifestations of polypoidal choroidal vasculopathy and pathogenesis of choroidal neo-vascularization. Am J Ophthalmol Case Rep. 2017 ;11:176-180.
Chen L, Zhang X, Gan Y., Liu B, Zhang Y, Wen F. Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2018;256(12):2283-2291.
Gupta RR, Iaboni DSM, Seamone ME, Sarraf D. Inner, outer, and full-thickness retinal folds after rhegmatogenous retinal detachment repair: A review. Surv Ophthalmol. 2019;64(2):135-161.
Sung IS, Park SY, Jeong KY, Kim HM. Investigation of the preventive effect of calcium on inflammation-mediated choroidal neovascularization. Life Sci.2019;233:116727.
Clemens CR, Eter N. Retinal pigment epithelium tears: risk factors, mechanism and therapeutic monitoring. Ophthalmologica. 2016;235(1):1-9.
Fragiotta S, Rossi T, Cutini A, Grenga PL, Vingolo EM. Рredictive factors for development of neovascular age-related macular degeneration: a spectral-domain optical coherence tomography study. Retina. 2018 Feb;38(2):245-252.
Wurm A, Pannicke T, Iandiev I, Bühner E, Pietsch UC, Reichenbach A, Wiedemann P, Uhlmann S, Bringmann A. Changes in membrane conductance play a pathogenic role in osmotic glial cell swelling in detached retinas. Am J Pathol. 2006;169(6):1990-1998.
Oellers P, Eliott D. Overloaded dysfunctional rpe leads to delayed absorption of subretinal fluid after retinal detachment repair. Ophthalmic Surg Lasers Imaging Retina.2017;48(10):852-855.
Yang D, Elner SG, Clark AJ, Hughes BA, Petty HR, Elner VM. Activation of P2X receptors induces apoptosis in human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011;52(3):1522-1530.
Madeira MH, Boia R, Elvas F, Martins T, Cunha RA, Ambrósio AF, Santiago AR.
Fälker K, Ljungberg LU, Kardeby C, Lindkvist M, Sirsjö A, Grenegård M. Adrenoceptor α2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cell Signal. 2019;59:96-109.
Qin D, Jiang Y, Jin X. Effect of macrophage migration inhibitory factor on inflammatory cytokines and fibrogenic gene expression in human RPE cells. Mol Med Rep. 2019;20(1):830-836.
Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report number 8. Arch Ophthalmol 2001;119:1417-36.
Reed RK, Rubin K. Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix. Cardiovasc Res. 2010;87(2):211-217.
Kawahara A, Hikichi T, Kitaya N, Takahashi J, Mori F, Yoshida A. Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits. Exp Eye Res. 2005;80(4):493-499.
Collison DJ, Tovell VE, Coombes LJ, Duncan G, Sanderson J. Potentiation of ATP-induced Ca2+ mobilisation in human retinal pigment epithelial cells. Exp Eye Res. 2005;80(4):465-475.
Reigada D, Zhang X, Crespo A, Nguyen J, Liu J, Pendrak K, Stone RA, Laties AM, Mitchell C. Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells. Purinergic Signal. 2006;2(3):499-507.
Wurm A, Pannicke T, Iandiev I, Francke M, Hollborn M, Wiedemann P, Reichenbach A, Osborne NN, Bringmann A. Purinergic signaling involved in Müller cell function in the mammalian retina. Prog Retin Eye Res. 2011;30(5):324-342.
Iandiev I, Uckermann O, Pannicke T, Wurm A, Tenckhoff S, Pietsch UC, Reichenbach A, Wiedemann P, Bringmann A, Uhlmann S. Glial cell reactivity in a porcine model of retinal detachment. Invest Ophthalmol Vis Sci. 2006;47(5):2161-2171.
Aires ID2, Boia R, Rodrreichigues-Neves AC, Madeira MH2, Marques C, Ambrósio AF, Santiago AR. Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation
Kauppinen A2, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci. 2016;73(9):1765-1786.
Pinna A MD2, Porcu T MD, D'Amico-Ricci G MD, Dore S MD2, Boscia F MD, Paliogiannis P, Carru C, Zinellu A. Complete blood cell count-derived inflammation biomarkers in men with age-related macular degeneration. Ocul Immunol Inflamm. 2018; 28:1-5.
Ribeiro LS, Migliari Branco L, Franklin BS. Regulation of innate immune responses by platelets. Front Immunol. 2019;10:1320.
Hackler PC, Reuss S, Konger RL, Travers JB, Sahu RP. Systemic Platelet-activating Factor Receptor Activation Augments Experimental Lung Tumor Growth and Metastasis. Cancer Growth Metastasis. 2014;7:27-32.
Lordan R, Tsoupras A, Zabetakis I. The potential role of dietary platelet-activating factor inhibitors in cancer prevention and treatment. Adv Nutr. 2019;10(1):148-164.
Moschos MM, Laios K, Androudi S, Ladas DS, Chatziralli IP. Anti-platelet effects of vitamin supplements in age-related macular degeneration: an in vitro study. Cutan Ocul Toxicol. 2018;37(3):207-209.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 551
Number of citations: 0
