Streptozotocin - an antibiotic used to induce diabetes on experimental animals
DOI:
https://doi.org/10.12775/JEHS.2020.10.09.110Keywords
STZ, streptozotocin, streptozocin, streptozotocin diabetesAbstract
Streptozotocin (STZ) is a cytostatic antibiotic produced by Streptomyces achromogenes. It is an inhibitor of DNA replication showing a special affinity for pancreatic β-cells DNA. It is used in medicine as an antineoplastic agent (indicated in the treatment of malignant neoplasms of pancreas) and in scientific research to induce hyperglycemia, insulitis, diabetes mellitus (DM), Alzheimer’s disease on experimental animals. Insulinopenia syndrome is called ‘streptozotocin diabetes’, caused by necrosis of the pancreatic β-cells. STZ induced DM offers a very cost-effective and expeditious technique in medical research.
References
Vavra JJ, Deboer C, Dietz A, et al. Streptozotocin, a new antibacterial antibiotic. Antibiot Annu. 1959 1960;7:230–5.
Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 1963 May;29:91–8.
Mansford KRL, Opie L. Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. The Lancet. 1968 Mar;291(7544):670–1.
Rerup CC. Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev. 1970 Dec;22(4):485–518.
Schein PS, Cooney DA, Vernon ML. The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity. Cancer Res. 1967 Dec;27(12):2324–32.
Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008 Feb;51(2):216–26.
Wang Z, Gleichmann H. GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes. 1998 Jan;47(1):50–6.
Imaeda A, Kaneko T, Aoki T, et al. DNA damage and the effect of antioxidants in streptozotocin-treated mice. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc. 2002 Jul;40(7):979–87.
Pieper AA, Verma A, Zhang J, Snyder SH. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci. 1999 Apr;20(4):171–81.
Masutani M, Suzuki H, Kamada N, et al. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2301–4.
Strandell E, Eizirik DL, Sandler S. Survival and B-cell function of mouse pancreatic islets maintained in culture after concomitant exposure to streptozotocin and nicotinamide. Exp Clin Endocrinol. 1989 May;93(2–3):219–24.
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