Natriuretic peptides and their usefulness in clinical practise

Authors

  • Aleksandra Skałecka Pulmonology Student Research Group at the Clinic of Pneumology, Oncology and Allergology, Medical University of Lublin https://orcid.org/0000-0002-3166-1296
  • Karol Krupa Pulmonology Student Research Group at the Clinic of Pneumology, Oncology and Allergology, Medical University of Lublin
  • Aleksandra Słabczyńska Pulmonology Student Research Group at the Clinic of Pneumology, Oncology and Allergology, Medical University of Lublin
  • Małgorzata Romaniuk Pulmonology Student Research Group at the Clinic of Pneumology, Oncology and Allergology, Medical University of Lublin https://orcid.org/0000-0001-8838-6291
  • Konrad Suswał Chair and Department of Pneumology, Oncology and Allergology, Medical University of Lublin https://orcid.org/0000-0001-5226-8779
  • Janusz Milanowski Chair and Department of Pneumology, Oncology and Allergology, Medical University of Lublin

DOI:

https://doi.org/10.12775/JEHS.2020.10.09.016

Keywords

natriuretic peptide, atrial natriuretic peptide, brain natriuretic peptide, heart failure, hypertrophic cardiomyopathy

Abstract

Natriuretic peptides are peptic hormones produced by atrial and ventricular myocytes, and by endothelium of blood vessels, that take part in homeostatic control of water and sodium levels, but also potassium transport, lipolysis in adipocytes and blood pressure regulation.  

 

Three different natriuretic peptides are distinguished: atrial natriuretic peptide (ANP), b-type natriuretic peptide (BNP) and c-type natriuretic peptide (CNP). Those peptides are responsible mostly for water-sodium homeostasis and regulation of blood pressure. Levels of natriuretic peptides increase significantly in diseases and disorders such as congestive heart failure and pulmonary hypertension, that is why natriuretic peptides were found useful in diagnosis and monitoring of said diseases. In clinical practise, BNP and NT-proBNP levels are mostly used.  

 

References

Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM. Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol. 2009;(191):341-366. doi:10.1007/978-3-540-68964-5_15

Santhekadur PK, Kumar DP, Seneshaw M, Mirshahi F, Sanyal AJ. The multifaceted role of natriuretic peptides in metabolic syndrome. Biomed Pharmacother. 2017;92:826-835. doi:10.1016/j.biopha.2017.05.136

Wong PC, Guo J, Zhang A. The renal and cardiovascular effects of natriuretic peptides. Adv Physiol Educ. 2017;41(2):179-185. doi:10.1152/advan.00177.2016

Volpe M, Carnovali M, Mastromarino V. The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment. Clin Sci (Lond). 2016;130(2):57-77. doi:10.1042/CS20150469

Forte M, Madonna M, Schiavon S, et al. Cardiovascular Pleiotropic Effects of Natriuretic Peptides. Int J Mol Sci. 2019;20(16):3874. Published 2019 Aug 8. doi:10.3390/ijms20163874

Working Group of the European Society of Cardiology (ESC) for the diagnosis and treatment of acute and chronic heart failure, ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure in 2016, Kardiologia Polska, 2016, 74, 10: 1037–1147.

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Published

2020-09-07

How to Cite

1.
SKAŁECKA, Aleksandra, KRUPA, Karol, SŁABCZYŃSKA, Aleksandra, ROMANIUK, Małgorzata, SUSWAŁ, Konrad and MILANOWSKI, Janusz. Natriuretic peptides and their usefulness in clinical practise. Journal of Education, Health and Sport. Online. 7 September 2020. Vol. 10, no. 9, pp. 137-142. [Accessed 27 November 2024]. DOI 10.12775/JEHS.2020.10.09.016.

Issue

Vol. 10 No. 9 (2020)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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