Assessment of biological activity of natural iron-containing mineral waters at their internal application
DOI:
https://doi.org/10.12775/JEHS.2020.10.06.038Keywords
ferrous mineral waters, metabolism, red blood, structural changes of internal organsAbstract
In experiments on rats of the Wi-star line, the influence of two iron-containing weakly mineralized mineral waters with a high content of organic matter (MW) from the sources № 13 and № 15 of Skhidnytsia deposit (Ukraine). It was determined that both MW do not have a toxic effect on their use on animals, as evidenced by the lack of significant structural and functional changes in the tissues of the stomach, kidneys, liver, and heart. It is established that MW from source No. 13 changes the activity of transamination processes in hepatocytes, increases bile formation and biliary excretion, and activates red blood counts. MW from source No. 15 has a similar effect, but more significantly affects the metabolism, red blood, and immune system. The research results justify the use of these iron-containing MW for the correction of iron deficiency conditions in laboratory animals.
References
Medical-hydrogeochemical factors of the geological environment of Ukraine. Ed by Rudko HI. Kyiv – Chernovtsy: Burek, 2015: 724 p.
Lemko IS, Feksishgasi BM, Kirtich LP. et al. Microelement composition of mineral water sand medical-geographical regionalization of Zakarpatiy. Medical hydrology and rehabilitation. 2005; 3(2): 4–13.
Nataliya Dragomiretska, Konstantin Babov, Sergey Gushcha, Irina Zabolotna, Alexander Plakida, Anna Izha, Irina Babova, Boris Nasibullin,Irina Trubka. Application of Mineral Waters in the Complex Treatment of Patients With Gastroesophageal Reflux Disease. Minerva Gastroenterol Dietol. 2020; Mar 24. doi: 10.23736/S1121-421X.20.02601-X.
Petraccia L, Liberati G, Masciullo SG, Grassi M, Fraioli A. Water, mineral waters and health.Clin.Nutr. 2006;25:377–385. doi: 10.1016/j.clnu.2005.10.002.
Shestopalov VM, Moiseeva NP, Ishchenko AP. et al. Lechebnye mineral'nye vody tipa «Naftusja» Ukrainskih Karpati Podol'ja [Naftusia medical waters of Ukrainian Carpathians and Podolia]. Chernovtsy: Bukrek, 2013: 600 p.
Albertini MC, Dacha М, Teodori L, Conti ME. Drinking mineral waters: biochemical effects and health implications – the state of the art // Int. J. Environmental Health. 2007;1(1):153–169. doi: https://doi.org/10.1504/IJENVH.2007.012230.
Gushcha SG, Nasibullin BA, Nikipelova EM, Badiuk N S. Comparative evaluation of the effectiveness of natural silicon mineral waters and their artificial analogics on the current experimental pathology of sleeve-surface tract.Journal of Education, Health and Sport. 2019;9(4):600– 610. doi: http://dx.doi.org/10.5281/zenodo.3237876
Nissenson AR, Goodnough LT, Dubois RW. Not Just an Innocent Bystander? Arch. Intern. Med. 2003 Jun 23;163(12):1400–4. doi: 10.1001/archinte.163.12.1400.
Belziti CA. Prevalence of anemia in heart failure and its effects on prognosis. Expert Rev Cardiovasc Ther. 2009 Feb;7(2):131-8. doi: 10.1586/14779072.7.2.131.
Oliveira F, Rocha S, Fernandes R. Iron metabolism: from health to disease. J Clin Lab Anal. 2014;28(3):210–218. doi:10.1002/jcla.21668.
Dutra-de-Oliveira JE, FerreiraJB, Vasconcellos VP, MarchiniJ.S. Drinking water as an iron carrier to control anemiainpre school childrenin a day-carecenter. J Am Coll Nutr. 1994 Apr;13(2):198-202. doi: 10.1080/07315724.1994.10718395.
Balarajan Y, Ramakrishnan U, Ozaltin E. еt al. Anaemia in Low-Income and Middle-Income Countries. Lancet. 2011 Dec 17;378(9809):2123–2135. doi: 10.1016/S0140-6736(10)62304-5.
Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014 Feb; 19(2): 164–174. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999603/
Wirth JP, Woodruff BA, Engle-Stone R, et al. Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.Am J ClinNutr. 2017;106(1):416–427. doi:10.3945/ajcn.116.143073.
Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann NY Acad Sci. 2019 Aug; 1450(1): 15–31.doi:10.1111/nyas.14092.
Petry N, Olofin I, Hurrel RF. еt al.The Proportion of Anemia Associated with Iron Deficiency in Low, Medium, and High Human Development Index Countries: A Systematic Analysis of National Surveys. Nutrients. 2016 Nov;8(11): 693. doi:10.3390/nu8110693.
Mineral waters of Ukraine / Ed. by Кolesnik Е.О., Bабоv К.D. – Кiev: 2005, 576 р.
Nasibullin BA, Gojenko AI, Tikhokhod LV. Features of structurally functional changes in a liver and mucous membrane of thin intestines for rats with modelling of deficiency of iron and possibility of their correction. Actual Problems of Transport Medicine. 2009;2(16):132–137. http://www.aptm.org.ua/wp-content/uploads/2013/09/aptm216-2009.pdf
Council Directive 86/609/EEC of 24 November 1986 on the Approximation of the Laws, Regulations and Administrative Provisions on the Member States Regarding the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. Official Journal of the European Communities. 1986;358:1–29.
Kozhemyakin YuN, Khromov OS, Boldyreva NE, Dobrelya NV, Sayfetdinova GA. Scientific and practical recommendations for the content of laboratory animals and work with them: monograph. – Кiev: Interservice, 2017: 182 р.
On approval of the recommendations of the research methods of biological effects of natural medical resources and preformed medicines: of Ministry of Health of Ukraine № 692, from 28.09.09. Kiev: 2009. http://old.moz.gov.ua/ua/portal/dn_20090928_692.html.
Lojda Z, Grossrau R, Schiebler TN. Enzyme Histochemistry. A Laboratory Manual. Springer-Verlag Berlin-Heidelberg New York 1979.
Vodi mіneral'nі fasovanі. Tehnіchnі umovi: DSTU 878-93. Chinnij vіd 1995-01-01. Kiїv: Derzhstandart Ukraїni, 1994. 88 s. [The waters are mineral packaged. Technical conditions: DSTU 878-93. Existing from 1995-01-01. Kyiv: State standard of Ukraine, 1994. 88 p. State standard of Ukraine].
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