The influence of thyroid function disorders on pregnant women on the Apgar scale and psychomotor development of the child in the first 18 months of life
DOI:
https://doi.org/10.12775/JEHS.2020.10.04.012Keywords
hypothyroidism, pregnancy, Apgar, physiotherapy, child development, dysfunction of the child.Abstract
Introduction. In the prenatal period, there are many exogenous and endogenous factors, which adversely affect the normal development of the fetus and may affect the further development of the child. The impaired reference level of thyroid hormones pregnant woman may entail a number of complications, especially in the first trimester of pregnancy, wherein the process takes place organogenesis and the formation of the nervous system.
Goal. The overall objective of the work is to verify the correlation between hypothyroidism and child developmental problems in the first eighteen months of life and the Apgar scale.
Materials and methods. The study included 200 pregnant women aged 17 to 40 years of age. The research tool was an online, proprietary questionnaire, which has been placed in social groups, which included pregnant women struggling with hypothyroidism.
Conclusions. Developmental disorders up to 18 months of children age occurred in 45% of women with thyroid dysfunction, of which 43% related to symptoms of neurological problems including 56% of impaired muscle tone. The present study demonstrates that the final outcome Apgar does not forecast problems in the course of further development of the child up to 18 months of age. Significant further research, which will help establish the presence of mechanisms adverse impact on offspring and pregnancy outcomes.
References
Dulek H., Vural F., Aka N., Zengin S.: The prevalence of thyroid dysfunction and its relationship with perinatal outcomes in pregnant women in the third trimester. North Clin. Istanb., 2019;6(3):267–272
Kroopnick JM., Kim CS.: Overview of hypothyroidism in Pregnancy. Semin. Reprod. Med., 2016; 34 (6): 323-330.
Alexander EK., Pearce EN., Brent GA., Brown RS., Chen H., Dosiou C. et al .: 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid, 2017; 27 (3): 315-389.
Zubkiewicz-Kucharska A., Chrzanów J., Noczyńska A.: Hashimoto's thyroiditis in mothers and thyroid function in infants - a prospective study. Endocrinol. Ped., 2015.14.3.52:9-14.
Andersen SL., Olsen J., Laurberg P.:Hypothyroidism and pregnancy loss: comparison with hyperthyroidism and diabetes in a Danish population-based study. Clin. Endocrinol. (Oxf)., 2016;85(6):962-970.
Skalkidou A., Bixo M., Sköldebrand Sparre AC., Strandell A., Lindén Hirschberg A., Filipsson Nyström H.: Hypothyroidism during pregnancy risks the child's neurocognitive development. New guidelines and remaining knowledge gaps. Lakartidningen, 2016;5;113.
Iwen KA., Lehnert H.: Thyroid and pregnancy. Internist (Berl)., 2018;59(7):654-660.
Official of the Republic of Polish laws. Regulation of the Minister of Health of 16 August 2018. On the organizational standard of perinatal care.
Ares Segura S., Temboury Molina C., Chueca Guindulain MJ., Grau Bolado G., Alija Merillas MJ., Caimari Jaume M., en representación del Grupo de trabajo de tiroides de la Sociedad Española de Endocrinología Pediátrica: Recommendations for the diagnosis and follow up of the foetus and newborn child born to mothers with autoimmune thyroid disease. An Pediatr. (Barc)., 2018;89(4):254.e1-254.e7.
Springer D., Jiskra J., Limanova Z., Zima T., Potlukova E.: Thyroid in pregnancy: From physiology to screening. Crit. Rev. Clin. Lab. Sci., 2017;54(2):102-116.
Maheshwari A., Bhide P., Pundir J., Bhattacharya S.: Routine serum thyroid-stimulating hormone testing-optimizing pre-conception health or generating toxic knowledge. Hum. Reprod., 2017;1;32(9):1779-1785.
Ben-Skowronek I.: Development of children of mothers with thyroid dysfunction. Endocrinol. Ped., 2015.14.1.50.53-58.
Taylor PN., Lazarus JH.: Hypothyroidism in Pregnancy. Endocrinol. Metab. Clin. North Am., 2019;48(3):547-556.
Andersen SL.: Frequency and outcomes of maternal thyroid function abnormalities in early pregnancy. Scand. J. Clin. Lab. Invest., 2019;79(1-2):99-107.
Razaz N., Cnattingius S., Joseph KS.: Association between Apgar scores of 7 to 9 and neonatal mortality and morbidity: population based cohort study of term infants in Sweden. BMJ., 2019;365: l1656.
Veltri F., Decaillet S., Kleynen P., Grabczan L., Belhomme J., Rozenberg S. i wsp. Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy: is it altered? Eur. J. Endocrinol., 2016;175(3):191-9.
Eshkoli T., Wainstock T., Sheiner E., Beharier O., Fraenkel M., Walfisch A.: Maternal Hypothyroidism during Pregnancy and the Risk of Pediatric Endocrine Morbidity in the Offspring. Am. J. Perinatol., 2019;36(9):975-980.
Plowden TC., Schisterman E., Sjaarda LA., Perkins NJ., Silver R., Radin R. et al .: Thyroid-stimulating hormone, anti–thyroid antibodies, and pregnancy outcomes. Am. J. Obstet. Gynecol., 2017;217(6), 697.e1–697.e7.
Korevaar TI., Steegers EA., Pop VJ., Broeren MA., Chaker L., de Rijke YB. et al : Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies. J. Clin. Endocrinol. Metab., 2017;1;102(1):69-77.
Fan X., Wu L.: The impact of thyroid abnormalities during pregnancy on subsequent neuropsychological development of the offspring: a meta-analysis. J. Matern. Fetal. Neonatal. Med., 2016;29(24):3971-6.
Lazarus JH., Taylor PN.: Hypothyroxinaemia and brain development. Acta Endocrinol. (Buchar)., 2016; 12(1):1–6.
Andersen SL., Andersen S., Vestergaard P., Olsen J.: Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study. Thyroid, 2018;28(4):537-546.
Grattan MJ., Thomas DS., Hornberger LK., Hamilton RM., Midodzi WK., Vohra S.: Maternal hypothyroidism may be associated with CHD in offspring. Cardiol. Young., 2015;25(7):1247-53.
Chen LM., Chen QS., Jin GX., Si GX., Zhang Q., Ye EL. et al : Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring. J. Perinatol., 2015;35(9):678-82.
Stagnaro-Green A.: Second trimester levothyroxine treatment for subclinical hypothyroidism or hypothyroxinaemia of pregnancy does not improve cognitive outcomes of children. Evid. Based. Med., 2017;22(4):149.
Li P., Lin S., Li L., Cui J., Zhou S., Fan J.: Effect of mildly elevated thyroid-stimulating hormone during the first trimester on adverse pregnancy outcomes. BMC Endocr. Disord., 2018;18(1):64.
Casey BM., Thom EA., Peaceman AM., Varner MW., Sorokin Y., Hirtz DG. et al : Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. N. Engl. J. Med., 2017;376(9):815-825.
Trumpff C., De Schepper J., Vanderfaeillie J., Vercruysse N., Van Oyen H., Moreno-Reyes R.: Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age. Arch. Dis. Child. 2016;101(12):1100–1106.
Razaz N., Cnattingius S., Persson M., Tedroff K., Lisonkova S., Joseph KS.: One-minute and five-minute Apgar scores and child developmental health at 5 years of age: a population-based cohort study in British Columbia, Canada. BMJ Open, 2019; 9(5):e027655.
Persson M., Razaz N., Tedroff K., Joseph KS., Cnattingius S.: Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden. BMJ, 2018; 360.
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