Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia
DOI:
https://doi.org/10.12775/JEHS.2020.10.01.003Keywords
contact dermatitis, pneumonia, cytokines, thiotriazolineAbstract
The aim of our research was to determine the character of the disturbances content level of pro-inflammatory interleukin-6, tumor necrosis factor-α and anti-inflammatory cytokine interleukin-10 (IL-10) in the serum of guinea pigs and estimation of thiotriazoline influence on the cytokine profile in the conditions of formation of combined pathology - experimental contact dermatitis and experimental pneumonia.
It has been determined significant advantage of pro-inflammatory cytokine activity, which increasing according the development of the combined pathological process and, simultaneously, reducing the anti-inflammatory IL-10. It has been detected corrective action of thiotriazoline on the investigated indices of cytokine profile.
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