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Journal of Education, Health and Sport

Anti-aging properties of metformin
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Anti-aging properties of metformin

Authors

  • Anna Małgorzata Łopuszyńska Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0001-5133-4180
  • Mateusz Pawlicki Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0001-8318-6573
  • Magdalena Kozioł Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-8671-5968
  • Aleksandra Krasa Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-0733-202X
  • Ewa Piekarska Student Scientific Association at Department of Epidemiology and Clinical Research Methodology Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-4954-379X
  • Halina Piecewicz-Szczęsna Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-0573-7226

DOI:

https://doi.org/10.12775/JEHS.2021.11.09.005

Keywords

metformin, anti-aging, aging

Abstract

 Introduction: Life expectancy of human population is being constantly prolonged, hence there is a lot of research into drug that will prevent the effects of aging. There are many reports that metformin, which is a drug used in type 2 diabetes, has anti-aging effects. It belongs to the group of biguanides and has been used since the 1950s. It is a relatively safe, cheap and effective drug, which makes it a promising subject for many studies. The purpose of this review is to present the latest developments in this field. 

Material and methods: PubMed scientific base was searched using following keywords: metformin, aging, anti-aging, in years 2017-2021. 

Results: Numerous studies show that metformin has an impact on aging through the nutrient pathway, AMPK signaling pathway, and its effects on reactive oxygen species. In addition, it has an anti-cancer effect, inhibiting, among others, rectal cancer cells and p53 mutant colon cancer. Research in rodents has shown that this drug has anti-aging effects on many organs, including the CNS, ovaries, prostate, heart muscle and skin. 

Conclusions: Metformin, which is the most commonly used oral drug in type 2 diabetes, has many other mechanisms of action. Its anti-aging effect works on many organs in our bodies, which gives hope to find an anti-aging substance. However, multicentre, randomized trials are needed to determine the exact anti-aging dose, its possible side effects, and effects on various organisms. 

References

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Y. Hong et al. The preventive effect of metformin on progression of benign prostate hyperplasia: A nationwide population-based cohort study in Korea; PLoS One. 2019; 14(7): e0219394. doi: 10.1371/journal.pone.0219394.

P. Zhao et al. Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application; Aging Cell. 2017 Oct; 16(5): 1083–1093. doi: 10.1111/acel.12635.

C. Kremslehner et al. Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage; Redox Biol. 2020 Oct; 37: 101583. doi: 10.1016/j.redox.2020.101583.

A. A. Soukas, H. Hao and L. Wu; Metformin as Anti-Aging Therapy: Is It for Everyone? Trends Endocrinol Metab. 2019 Oct; 30(10): 745–755. doi: 10.1016/j.tem.2019.07.015.

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Published

2021-09-03

How to Cite

1.
ŁOPUSZYŃSKA, Anna Małgorzata, PAWLICKI, Mateusz, KOZIOŁ, Magdalena, KRASA, Aleksandra, PIEKARSKA, Ewa & PIECEWICZ-SZCZĘSNA, Halina. Anti-aging properties of metformin. Journal of Education, Health and Sport [online]. 3 September 2021, T. 11, nr 9, s. 37–42. [accessed 27.3.2023]. DOI 10.12775/JEHS.2021.11.09.005.
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Vol. 11 No. 9 (2021)

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Review Articles

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