The role of adipocytokines and endothelial dysfunction with irritable bowel syndrome associated with obesity
Keywordsirritable bowel syndrome, obesity, adipocytokines, endothelial dysfunction
The article contains the analysis of results concerning investigation of adipocytokines content and endothelial dysfunction in 97 patients with irritable bowel syndrome associated with obesity.
The blood serum was examined for the content of adipocytokines (leptin, adiponectin, resistin), stable nitrogen monoxide metabolites (nitrites/nitrates), endothelin-1, intercellular adhesion molecule 1 (ICAM-1), and the number of circulating endothelial cells (CEC).
Patients with IBS associated with obesity and prevailing diarrhea are found to develop a prominent imbalance of adipocytokines which is manifested in high levels of leptin and resisin and low level of adiponectin in the blood serum. Endothelial dysfunction evidenced by a high level of endothelin-1, the number of circulating endothelial cells, general NO and intercellular adhesion molecules 1, is characteristic for patients with IBS associated with obesity and prevailing diarrhea.
Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA. 2015 Mar 3;313(9):949-58.
Defrees DN, Bailey J. Irritable Bowel Syndrome: Epidemiology, Pathophysiology, Diagnosis, and Treatment. Prim Care. 2017 Dec;44(4):655-671.
Ford AC, Lacy BE, Talley NJ. Irritable Bowel Syndrome. N Engl J Med. 2017 Jun 29;376(26):2566-2578.
Gridnieva S, Reznichenko O, Martynenko M. Irritable bowel syndrome with constipation: issues of pathogenesis, diagnostics and treatment. Actual problems of modern medicine. 2020; 6: 4-11.
Dereń K, Nyankovskyy S, Nyankovska O, Łuszczki E, Wyszyńska J, Sobolewski M, Mazur A. The prevalence of underweight, overweight and obesity in children and adolescents from Ukraine. Sci Rep. 2018 Feb 26;8(1):3625.
Kristen R Weaver, Christina M Boulineaux, Jeffrey M Robinson, Kierra Butler, Margaret M Heitkemper, Wendy A Henderson. Sex Hormones, BDNF, Leptin, and TGF-β1 in Females With IBS: A Pilot InvestigationBiol Res Nurs 2021 Apr;23(2):231-237.
An S, Zong G, Wang Z, Shi J, Du H, Hu J. Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrheaNeurogastroenterol Motil 2016 Jul;28(7):1083-93.
Ford AC, Bercik P, Morgan DG. [et al.] Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care. Gastroenterology. 2013; 145(6): 1262–1270.
Roshandel SS, Keshtkar G. Serum Leptin Levels and Irritable Bowel Syndrome: A New Hypothesis. Journal of Clinical Gastroenterology. 2009; 43(9): 826-830.
Liu De-Rong, Xu Xiao-Juan, Yao Shu-Kun. Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol. 2018; 24(1): 46–57.
Russo F, Chimienti G, Riezzo G., Linsalata M, D'Attoma B, Clemente C, Orlando A. Adipose Tissue-Derived Biomarkers of Intestinal Barrier Functions for the Characterization of Diarrhoea-Predominant IBS. Dis Markers. 2018; 2018: 1827937. Published online 2018 Nov 28. doi: 10.1155/2018/1827937.
Thierry P, Pierre-Michel H, Eve G, Mariné BE, Faredj C, Xavier C-BF, Xavier H, Alber T. Fatigue in irritable bowel syndrome: characterization and putative role of leptin European Journal of Gastroenterology & Hepatology. 2007; 19(3): 237-243.
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