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Journal of Education, Health and Sport

Morphometric evaluation of features of remodeling of chondrocites of joint surfaces of temporomandibular joint of experimental animals in hyperglycemia
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  • Morphometric evaluation of features of remodeling of chondrocites of joint surfaces of temporomandibular joint of experimental animals in hyperglycemia
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Morphometric evaluation of features of remodeling of chondrocites of joint surfaces of temporomandibular joint of experimental animals in hyperglycemia

Authors

  • Mykhailo Hnatiuk I.Ya. Horbachevsky Ternopil National Medical University
  • Lesia Rubas I.Ya. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.12775/JEHS.2021.11.06.014

Keywords

hondrocytes, temporomandibular joint, hyperglycemia, cartilaginous tissue

Abstract

Aim: to study morphometrically the peculiarities of remodeling of chondrocytes of the articular surfaces of the temporomandibular joint in hyperglycemia.

Materials and methods: Quantitative morphological methods were used to study diameters of chondrocytes and their nuclei, nuclear-cytoplasmic relationship in these cells, relative volume of damaged chondrocytes, intercellular-chondrocytic relationship in mature chondrocytes of the articular surfaces of the temporomandibular joint of 45 laboratory mature white male rats with simulated diabetes.

Results: A comprehensive analysis of the morphometric parameters presented in the article showed that they did not differ in the articular surfaces of the temporal fossa and mandibular head of the intact temporomandibular joint. The expressed structural changes of chondrocytes were revealed at a monthly and a two-month diabetic arthropathy of this joint.

Conclusions: Proceeded studies and obtained results suggest that prolonged hyperglycemia leads to diabetic arthropathy of the TMJ, which is characterized by atrophy of chondrocytes, violation of nuclear-cytoplasmic relationships, an increase in the relative volume of damaged chondrocytes and volume of intercellular substance. The detected changes in quantitative morphological parameters depended on the duration of hyperglycemia and dominated in the cartilaginous tissue of the articular surface of the mandibular head.

References

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Gzhibovsky AI, Ivanov OI, Gorbatova MA. Sravnenie kolichestvennikh dannykh dvukh parnykh vyborok s polzovaniem programnogo obespecheniia Statistika i SPSS: parametricheskie i neparametricheskie kriterii. [Comparison of quantitative data of two pair samples using software Statistics i SPSS: parametric and nonparametric criteria]. Nauka i zdravokhranenie. 2016; 3: 5-25. Russian.

Goralsky LP, Khomich VP, Konopsky OI. Osnovy gistologichnoi tekhniky I morfofunktsionalni metody doslidzennia v normi i pry patologii. [Fundamentals of histological technique and morphofunctional methods of research in normal and in pathology]. Zhytomyr: Polissia. 2011; 288. Ukrainian.

Gusak EV, Pogorelova MV, Tkach GF, Danilchenko SM. Mikroelementarnyi sklad dovgykh ta mishanykh kistok skeletal u normi [Microelement composition of long and mixed skeletal bones in the norm]. Ukrainskyi morfologichnyi almanakh. 2010; 8 (4): 51-55. Ukrainian.

Kryzyna OV. Trofichni porushennia tkanyn nyzhnikh kintsivok pry tsukrovomu diabeti 2 typu. [Trophic disorders of the tissues of the lower extremities in type 2 diabetes]. Klinichna endokrynologiia ta endokrynna khirurgiya. 2018; 1 (6): 15-24. Ukrainian.

Orlenko VL. Gormonalni kharakterystyky diabet-asotsiiovanykh osteoartrytiv. [Hormonal characteristics of diabetes-associated osteoarthritis]. Visnyk problem biologii i medytsyny. 2020; 2 (159): 138-143. Ukrainian.

Reznikov OG. Zagalni etychni pryntsypy eksperymentiv na tvarynakh. [General ethical principles of animal experiments]. Endokrynologia. 2003; 8 (1): 142-145. Ukrainian.

Rubas LV. Dynamika zmin mineralnogo skladu mikro- ta macroelementiv kistkovoyi tkanyny skronevo-nyzhnioshchelepnykh suglobiv pry tsukrovomu diabeti. [Dynamics of changes in the mineral composition of micro- and macroelements of bone tissue of the temporomandibular joints in diabetes] Visnyk medychnykh I biologichnykh doslidzhen. 2020; 3 (5): 99-101. Ukrainian.

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Published

2021-06-25

How to Cite

1.
HNATIUK, Mykhailo and RUBAS, Lesia. Morphometric evaluation of features of remodeling of chondrocites of joint surfaces of temporomandibular joint of experimental animals in hyperglycemia. Journal of Education, Health and Sport. Online. 25 June 2021. Vol. 11, no. 6, pp. 137-142. [Accessed 4 July 2025]. DOI 10.12775/JEHS.2021.11.06.014.
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Vol. 11 No. 6 (2021)

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Research Articles

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