The dynamics of TNF-α and IFN-γ content in adult patients with measles depending on the severity of the disease
DOI:
https://doi.org/10.12775/JEHS.2021.11.04.008Keywords
measles in adults, severity, cytokinesAbstract
Background. Measles is an acute viral infection, predominantly of childhood ages. However, in recent years, the incidence of measles among adults has significantly increased, with the development of a severe and complicated course of the disease.
Materials and methods. The study included 175 patients with measles and 30 healthy people. The quantitative content of TNF-α and IFN-γ in blood serum was determined by enzyme-linked immunosorbent assay. Statistical processing was performed in program "STATISTICA for Windows 13" (StatSoft Inc., No. JPZ804I382130ARCN10-J).
Results. A study of 175 measles patients found the frequency and spectrum of complications in adult patients depending on the severity of the disease and dynamics of TNF-α and IFN-γ level in blood serum. It is shown that frequency and range of complications in adult patients with measles depends on the severity of the disease. Patients with severe measles were more likely to develop complications from the respiratory system (p <0.01) due to the formation of pneumonia (p = 0.0001) and from the gastrointestinal tract with more frequent development of hepatitis (p = 0.0001) and enteritis (p = 0.0001), compared with moderate patients. In patients with severe measles, content of TNF-α in blood serum is the highest and exceeds both corresponding rate of healthy individuals (p <0.05) and measles patients with moderate course (p <0.05). Higher levels of TNF-α in the serum of measles patients during rash period are associated with severe course of the disease (p = 0.008). At the time of hospitalization of adult patients with measles during the rash IFN-γ content in the serum is higher (p <0.05) than in healthy individuals, both in patients with severe (p <0.05) and moderate course of measles (p <0.05). In the dynamics of IFN-γ content in the serum patients of both study groups decreases (p <0.05), compared with hospitalization, and at the time of discharge is not statistically different from that of healthy people (p> 0.05).
Conclusions. Patients with severe measles compared with moderate measles patients more likely developed complications from respiratory system (p <0.01) and gastrointestinal system (p <0.01). In patients with severe measles, content of TNF-α in blood serum is highest that corresponding rate of healthy individuals (p <0.05) and patients with moderate course
(p <0.05). At the hospitalization time during the rash IFN-γ content in the serum is higher
(p <0,05) than in healthy individuals, both in patients with severe (p <0,05) and with moderate measles (p <0,05).
References
Report of the sixty-third session of the WHO Regional Committee for Europe. Çeşme Izmir, Turkey, 16–19 September 2013. Copenhagen: WHO Regional Office for Europe. – 2013. URL:http://www.euro.who.int/__data/assets/pdf_file/0005/234734/Report-of-the-sixty-third-session-of-the-WHO-Regional-Committee-for-Europe-Eng.pdf.
Kramarov S.O., Yevtushenko V.V., Kovalyux I.Yu., ta in. Klinichna kartyna koru v ditej, gospitalizovanyx pid chas spalaxu 2017-2018 r.r. Aktualna infektologiya. 2018; 6(5): 55-60 [in Ukraine].
Mojseyeva G.V., Zadorozhna V.I., Demchyshyna I.V., Novye L.V. Monitoring populyacijnogo imunitetu proty koru naselennya Ukrayiny. Infekcijni xvoroby. 2010; 3: 5-13 [in Ukraine].
Werber D, Hoffmann A, Santibanez S [et al]. Large measles outbreak introduced by asylum seekers and spread among the insufficiently vaccinated resident population, Berlin, October 2014 to August 2015. Euro Serveill. 2017; 22 (34).
Lancella L, Di Camillo C, Vittucci AC [et al]. Measles lessons in an anti-vaccination era: public health is a social duty, not a political option. Ital. J. Pediatr. 2017; 43:102.
Laksono BM, de Vries RD, McQuaid S, Duprex WP, de Swart RL. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016; 8 (8): 231.
Andrejchyn M.A., Vasylyeva N.A., Josyk Ya.I. Rol interlejkiniv u patogenezi grypu ta inshyx gostryx respiratornyx virusnyx infekciyax. Zhurnal NAMN Ukrayiny. 2015; 21(1):122-127 [in Ukraine].
Tecu C, Mihai ME, Alexandrescu VI [et al]. Single and multipathogen viral infections in hospitalized children with acute respiratory infections. Roum. Arch. Microbiol. Immunol. 2013; 72 (4): 242-249.
Rajan D, McCracken CE, Kopleman HB [et al]. Human rhinovirus induced cytokine/chemokine responses in human airway epithelial and immune cells. PLoS One. 2014; 9:3.
Surveillance guidelines for measles, rubella and congenital rubella syndrome in the WHO European Region. Update December 2012. Copenhagen, WHO Regional Office for Europe, 2013. URL:http://www.euro.who.int/__data/assets/pdf_file/0018/79020/e93035-2013.pdf, accessed 17 June 2013.
Ryabokon Yu. Yu., Bilokobyla S. O., Ryabokon O. V. Suchasnyj perebig koru v doroslyx (oglyad literatury). Zaporizkyj medychny`j zhurnal. 2019; 5 (116): 697–701.
Premaratna R, Luke N, Perera H. Sporadic cases of adult measles: a research article. BMC. 2017; 10: 38.
Dinh A, Fleuret V, Hanslik T. Liver involvement in adults with measles. International Journal of Infectious Diseases. 2013; 17 (12): 1243-1244.
Casanova-Cardiel LJ, Hermida-Escobedo C. Measles in young adult. Clinical features of 201 cases. Rev. Invest. Clin. 1994; 46 (2): 93-98.
Shostakovych-Koreczka LR, Mavrutenkov VV, Cherginecz AV ta in. Kir (lekciya, prodovzhennya). Medychni perspektyvy. 2013;4 (18):4-15.
Griffin DE. Measles virus-induced suppression of immune responses. Immunol Rev. 2010; 236:176–189.
Jaap Ten Oever, Anca Riza, Mihaela Sabou, Cristina Cismaru, Mihai G Netea [et al]. Characterization of the Acute Inflammatory Response in Measles Infection. J Pediatric Infect Dis Soc. 2014; 3(3):197-200.
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